HMGA1 is induced by Wnt/β-catenin pathway and maintains cell proliferation in gastric cancer

American Journal of Pathology

Volumn 175, Issue 4, 2009, Pages 1675-1685

  Akaboshi, Shin Ichi ^a,c   Watanabe, Sugiko ^a   Hino, Yuko ^a   Sekita, Yoko ^a   Xi, Yang ^a   Araki, Kimi ^a   Yamamura, Ken Ichi ^a   Oshima, Masanobu ^b   Ito, Takaaki ^c   Baba, Hideo ^c   Nakao, Mitsuyoshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; HIGH MOBILITY GROUP A PROTEIN; HIGH MOBILITY GROUP A1 PROTEIN; UNCLASSIFIED DRUG; WNT3A PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE; GENE EXPRESSION; HMGA1 GENE; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; STOMACH CANCER; UPREGULATION;

EID: 73549090376     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2009.090069     Document Type: Article

References (43)

1. Parkin DM, Bray F, Ferlay J, Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 2005, 55:74-108
2. Ushijima T, Sasako M: Focus on gastric cancer. Cancer Cell 2004, 5:121-125
3. Kapadia CR: Gastric atrophy, metaplasia, and dysplasia: a clinical perspective. J Clin Gastroenterol 2003, 36:S29-S36
4. Clouston AD: Timely topic: premalignant lesions associated with adenocarcinoma of the upper gastrointestinal tract. Pathology 2001, 33:271-277
5. Sgarra R, Rustighi A, Tessari MA, Di Bernardo J, Altamura S, Fusco A, Manfioletti G, Giancotti V: Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer. FEBS Lett 2004, 574:1-8
6. Fusco A, Fedele M: Roles of HMGA proteins in cancer. Nat Rev Cancer 2007, 7:899-910
7. Reeves R: Molecular biology of HMGA proteins: hubs of nuclear function. Gene 2001, 277:63-81
8. Zhou X, Benson KF, Ashar HR, Chada K: Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 1995, 376:771-774
9. Chiappetta G, Avantaggiato V, Visconti R, Fedele M, Battista S, Trapasso F, Merciai BM, Fidanza V, Giancotti V, Santoro M, Simeone A, Fusco A: High level expression of the HMGI (Y) gene during embryonic development. Oncogene 1996, 13:2439-2446
10. Wood LJ, Mukherjee M, Dolde CE, Xu Y, Maher JF, Bunton TE, Williams JB, Resar LM: HMG-I/Y, a new c-myc target gene and potential oncogene. Mol Cell Biol 2000, 20:5490-5502
11. Abe N, Watanabe T, Masaki T, Mori T, Sugiyama M, Uchimura H, Fujioka Y, Chiappetta G, Fusco A, Atomi Y: Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins. Cancer Res 2000, 60:3117-3122
12. Reeves R, Edberg DD, Li Y: Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells. Mol Cell Biol 2001, 21:575-594
13. Nam ES, Kim DH, Cho SJ, Chae SW, Kim HY, Kim SM, Han JJ, Shin HS, Park YE: Expression of HMGI(Y) associated with malignant phenotype of human gastric tissue. Histopathology 2003, 42:466-471
14. Evans A, Lennard TW, Davies BR: High-mobility group protein 1(Y): metastasis-associated or metastasis-inducing? J Surg Oncol 2004, 88:86-99
15. Watanabe S, Ueda Y, Akaboshi S, Hino Y, Sekita Y, Nakao M: HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. Am J Pathol 2009, 174:854-868
16. Peifer M, Polakis P: Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus. Science 2000, 287:1606-1609
17. Klaus A, Birchmeier W: Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008, 8:387-398
18. Clevers H: Wnt/β-catenin signaling in development and disease. Cell 2006, 127:469-480
19. Reya T, Clevers H: Wnt signalling in stem cells and cancer. Nature 2005, 434:843-850
20. Polakis P: Wnt signaling and cancer. Genes Dev 2000, 14:1837-1851
21. Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y, Nakamura Y: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000, 24:245-250
22. Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, Christensen E, Schmidt SS, Roche PC, Smith DI, Thibodeau SN: Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling. Nat Genet 2000, 26:146-147
23. Clements WM, Wang J, Sarnaik A, Kim OJ, MacDonald J, Fenoglio-Preiser C, Groden J, Lowy AM: β-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res 2002, 62:3503-3506
24. Oshima H, Matsunaga A, Fujimura T, Tsukamoto T, Taketo MM, Oshima M: Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway. Gastroenterology 2006, 131:1086-1095
25. Cleynen I, Huysmans C, Sasazuki T, Shirasawa S, Van de Ven W, Peeters K: Transcriptional control of the human high mobility group A1 gene: basal and oncogenic Ras-regulated expression. Cancer Res 2007, 67:4620-4629
26. Xiang YY, Wang DY, Tanaka M, Suzuki M, Kiyokawa E, Igarashi H, Naito Y, Shen Q, Sugimura H: Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa. Int J Cancer 1997, 74:1-6
27. Lee S, Baek M, Yang H, Bang YJ, Kim WH, Ha JH, Kim DK, Jeoung DI: Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays. Cancer Lett 2002, 184:197-206
28. Ikenoue T, Ijichi H, Kato N, Kanai F, Masaki T, Rengifo W, Okamoto M, Matsumura M, Kawabe T, Shiratori Y, Omata M: Analysis of the β-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells. Jpn J Cancer Res 2002, 93:1213-1220
29. Hino S, Michiue T, Asashima M, Kikuchi A: Casein kinase Iε enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of β-catenin. J Biol Chem 2003, 278:14066-14073
30. Zhu H, Mazor M, Kawano Y, Walker MM, Leung HY, Armstrong K, Waxman J, Kypta RM: Analysis of Wnt gene expression in prostate cancer: mutual inhibition by WNT11 and the androgen receptor. Cancer Res 2004, 64:7918-7926
31. Pedulla ML, Treff NR, Resar LM, Reeves R: Sequence and analysis of the murine Hmgiy (Hmga1) gene locus. Gene 2001, 271:51-58
32. Lauren P: The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965, 64:31-49
33. Liu J, Schiltz JF, Shah PC, Benson KF, Chada KK: Genomic structure and expression of the murine Hmgi (y) gene. Gene 2000, 246:197-207
34. Giannini G, Cerignoli F, Mellone M, Massimi I, Ambrosi C, Rinaldi C, Dominici C, Frati L, Screpanti I, Gulino A: High mobility group A1 is a molecular target for MYCN in human neuroblastoma. Cancer Res 2005, 65:8308-8316
35. Taketo MM: Wnt signaling and gastrointestinal tumorigenesis in mouse models. Oncogene 2006, 25:7522-7530
36. Gregorieff A, Clevers H: Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev 2005, 19:877-890
37. Mishra L, Shetty K, Tang Y, Stuart A, Byers SW: The role of TGF-β and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene 2005, 24:5775-5789
38. Guilford P, Hopkins J, Harraway J, McLeod M, McLeod N, Harawira P, Taite H, Scoular R, Miller A, Reeve AE: E-cadherin germline mutations in familial gastric cancer. Nature 1998, 392:402-405
39. Himes SR, Reeves R, Attema J, Nissen M, Li Y, Shannon MF: The role of high-mobility group I(Y) proteins in expression of IL-2 and T cell proliferation. J Immunol 2000, 164:3157-3168
40. John S, Reeves RB, Lin JX, Child R, Leiden JM, Thompson CB, Leonard WJ: Regulation of cell-type-specific interleukin-2 receptor α-chain gene expression: potential role of physical interactions between Elf-1. HMG-I(Y), and NF-κB family proteins. Mol Cell Biol 1995, 15:1786-1796
41. Battista S, Pentimalli F, Baldassarre G, Fedele M, Fidanza V, Croce CM, Fusco A: Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation. FASEB J 2003, 17:1496-1498
42. Ueda Y, Watanabe S, Tei S, Saitoh N, Kuratsu J, Nakao M: The high mobility group protein HMGA1 inhibits retinoblastoma protein-mediated cellular G0 arrest. Cancer Sci 2007, 98:1893-1901
43. Fukamachi H, Ichinose M, Tsukada S, Kurokawa K, Shiokawa K, Miki K Takeuchi S: Growth of fetal rat gastro-intestinal epithelial cells is region-specifically controlled by growth factors and substrata in primary culture. Develop Growth Differ 1995, 37:11-19