Carbon-14 radiosynthesis of combretastatin A-1 (CA1) and its corresponding phosphate prodrug (CA1P)

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 52, Issue 14, 2009, Pages 567-570

  Brown, Rodney T ^a   Murrell, Victor L ^a   McMordie, Austin ^a   Sriram, Madhavi ^b   Pinney, Kevin G ^b   Sharma, Suman ^c   Chaplinc, David J ^c  

^a Almac Sciences   (United Kingdom)

^b BAYLOR UNIVERSITY   (United States)

^c Coxigene Inc ^*  (United States)

Author keywords

CA1; CA1P; CA4; Combretastatin; Oxi4503; Tumour

Indexed keywords

CARBON; ETHYLENE;

CA1P; CA4; CARBON 14; COMBRETASTATIN; COMBRETASTATIN A-1; NATURAL PRODUCTS; OXI4503; PRODRUGS; RADIOSYNTHESIS; WILLOW TREES;

ALKYLATION;

1 (3',4',5' TRIMETHOXYPHENYL) 2 (2'',3'' DIHYDROXY 4'' METHOXYPHENYL)ETHENE C 14; 1 (3',4',5' TRIMETHOXYPHENYL) 2 [2'',3'' DI[(MONOPOTASSIUM)PHOSPHATE] 4'' METHOXYPHENYL]ETHENE C 14; BROMINE DERIVATIVE; CARBON 14; COMBRETASTATIN A1; COMBRETASTATIN A1 PHOSPHATE; ESTER DERIVATIVE; HYDROCHLORIC ACID; METHYL IODIDE; PHOSPHITE; RADIOPHARMACEUTICAL AGENT; TRIMETHYLSILYLBROMIDE; TRIMETHYLSILYLESTER; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT;

ARTICLE; DEBENZYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; ISOMERIZATION; ISOTOPE LABELING; METHYLATION;

COMBRETACEAE; SALIX;

EID: 73549088056     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/JLCR.1676     Document Type: Article

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