Drug interaction potential of the seed extract of Urtica urens L. (dwarf nettle)

Phytotherapy Research

Volumn 23, Issue 12, 2009, Pages 1763-1770

  Agus, Hizlan H ^a   Tekin, Pelin ^a   Bayav, Merve ^a   Semiz, Asli ^a   Sen, Alaattin ^a  

^a PAMUKKALE UNIVERSITY   (Turkey)

Author keywords

CYP2C6; CYP2D1 2; CYP2E1; CYP3A1; Urtica urens

Indexed keywords

AMINOPYRINE N DEMETHYLASE; CYTOCHROME P450 2D1; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; DIMETHYLNITROSAMINE DEMETHYLASE; GLUTATHIONE TRANSFERASE; MESSENGER RNA; PLANT EXTRACT; UNCLASSIFIED DRUG; URTICA URENS EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DWARF NETTLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; IN VIVO STUDY; KIDNEY; LIVER; LUNG; MALE; MEDICINAL PLANT; NONHUMAN; PLANT SEED; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; TISSUE DISTRIBUTION; URTICA URENS; WESTERN BLOTTING;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; GLUTATHIONE TRANSFERASE; HERB-DRUG INTERACTIONS; KIDNEY; LIVER; LUNG; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; SEEDS; URTICACEAE;

RATTUS; URTICA; URTICA URENS;

EID: 73449137576     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2848     Document Type: Article

References (54)

1. Almeida C, Grimsley EW. 1996. Coma from the health food store: interaction between kava and alprazolam. Ann Intern Med 125: 940-941.
2. Arinç E, Şen A. 1994. Effects of in vivo benzo(a)pyrene treatment on liver microsomal mixed-function oxidase activities of gilthead seabream (Sparus aurata). Comp Biochem Physiol C Toxicol Pharmacol 107: 405-414.
3. Aydin M, Aslaner A, Zengin A. 2006. Using Urtica dioica in esophageal cancer. A report of a case. Internet J Surg 7(2) (available at: http://www.ispub.com/ostia/ index.php?xmlFilePath=journals/ijs/ vol7n2/esophageal.xml).
4. Brady JE, Ishizaki H, Fukuto JM et al. 1991. Inhibition of cytochrome P4502E1 by diallyl sulfide and its metabolites. Chem Res Toxicol 4: 642-647.
5. Burke MD, Mayer RT. 1974. Ethoxyresorufin: direct fluorometric assay of microsomal O-dealkylation which is preferentially induced by 3-methylcholanthrene. Drug Metab Dispos 2: 583-588.
6. Catterall F, McArdle NJ, Mitchell L, Papayanni A, Clifford MN, Ioannides C. 2003. Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. Food Chem Toxicol 41: 1141-1147.
7. Cochin J, Axelrod J. 1959. Biochemical and pharmacological changes in the rat following chronic administration of morphine nalorphine and normorphine. J Pharmacol Exp Ther 125: 105-110.
8. Ding X, Kaminsky LS. 2003. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol 43: 149-175.
9. Flockhart DA. 1995. Drug interactions and the cytochrome P450 system. The role of cytochrome P4502C19. Clin Pharmacokinet 29: 45-52.
10. Goodwin B, Moore LB, Stoltz CM, McKee DD, Kliewer SA. 2001. Regulation of human CYP2B6 gene by the nuclear pregnane X receptor. Mol Pharmacol 60: 427-431.
11. Goodwin B, Redinbo MR, Kliewer SA. 2002. Regulation of cyp3a gene transcription by the pregnane x receptor. Annu Rev Pharmacol Toxicol 42: 1-23.
12. Guengerich FP, Kim DH, Iwasaki M. 1991. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 4: 391-407.
13. Guyonnet D, Belloir C, Suschetet M, Siess MH, Le Bon AM. 2000. Liver subcellular fractions from rats treated by organosulfur compounds from Allium modulate mutagen activation. Mutat Res 466: 17-26.
14. Gyamfi MA, Tanaka T, Aniya T. 2004. Selective suppression of cytochrome P450 gene expression by the medicinal herb, Thonningia sanguinea in rat liver. Life Sci 74: 1723-1737.
15. Habig WH, Pabst MJ, Jakoby WB. 1974. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139.
16. Hedlund E, Gustafsson JA, Warner M. 2001. Cytochrome P450 in the brain: a review. Curr Drug Metab 2: 245-263.
17. Hellum BH, Zhuohan H, Nilsen OG. 2007. The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes. Basic Clin Pharmacol Toxicol 100: 23-30.
18. Imai Y, Ito A, Sato R. 1966. Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J Biochem (Tokyo) 60: 417-428.
19. Jang EH, Park YC, Chung WG. 2004. Effects of dietary supplements on induction and inhibition of cytochrome P450s protein expression in rats. Food Chem Toxicol 42: 1749-1756.
20. Kliewer SA, Moore JT, Wade L et al. 1998. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92: 73-82.
21. Konrad L, Muller HH, Lenz C, Laubinger H, Aumuller G, Lichius JJ. 2000. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med 66: 44-47.
22. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-684.
23. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurements with Folin-phenol reagent. J Biol Chem 193: 265-275.
24. Mannervik B, Alin P, Guthenberg C et al. 1985. Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. PNAS 82: 7202-7206.
25. Manzi SF, Shannon M. 2005. Drug interactions - a review. Clin Pediatr Emerg Med 6: 93-102.
26. Markowitz JS, DeVane CL, Boulton DW, Carson SW, Nahas Z, Risch SC. 2000. Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers. Life Sci 66(9): L133-L139.
27. Moon YJ, Wang X, Morris ME. 2006. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol in Vitro 20: 187-210.
28. Moore LB, Goodwin B, Jones SA et al. 2000. St John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. PNAS 97: 7500-7502.
29. Nash T. 1953. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem J 55: 416-421.
30. Nelson DR, Koymans L, Kamataki T et al. 1996. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6: 1-42.
31. Ozkarsli M, Sevim H, Sen A. 2008. In vivo effects of Urtica urens (dwarf nettle) on the expression of CYP1A in control and 3-methylcholanthrene-exposed rats. Xenobiotica 38: 48-61.
32. Pelkonen O, Breimer DD. 1994. Role of environmental factors in the pharmacokinetics of drugs: Considerations with respect to animal models, P450 enzymes, and probe drugs. In Handbook of Experimental Pharmacology, Vol 110, Welling PG, Balant LP (eds). Springer-Verlag: Berlin, 289-332.
33. Pieroni A, Janiak V, Durr CM, Ludeke S, Trachsel E, Heinrich M. 2002. In vitro antioxidant activity of non-cultivated vegetables of ethnic Albanians in Southern Italy. Phytother Res 16: 467-473.
34. Piscitelli SC, Burstein AH, Welden N, Gallicano KD, Falloon J. 2002. The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis 34: 234-238.
35. Riehemann K, Behnke B, Schulze-Osthoff K. 1999. Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-κB. FEBS Lett 442: 89-94.
36. Rodriguez-Antona C, Jover R, Gomez-Lechon MJ, Castell JV. 2000. Quantitative RT-PCR measurement of human cytochrome P450s: application to drug induction studies. Arch Biochem Biophys 376: 109-116.
37. Rowin J, Lewis SL. 1996. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 46: 1775-1776.
38. Ryu SD, Chung WG. 2003. Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplements in rats and humans. Food Chem Toxicol 41: 861-866.
39. Samur M, Bozcuk HS, Kara A, Savas B. 2001. Factors associated with utilization of nonproven cancer therapies in Turkey. A study of 135 patients from a single center. Support. Care Cancer 9: 452-458.
40. Schenkman JB, Cinti DL. 1978. Preparation of microsome with calcium. In Methods in Enzymology, Vol LII C, Fleischer SF, Packer L (eds). Academic Press: New York, 83- 89.
41. Schmiedlin-Ren P, Edwards DJ, Fitzsimmons ME et al. 1997. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab Dispos 25: 1228-1233.
42. Sen A, Arinc E. 1998. Preparation of highly purified cytochrome P4501A1 from leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular and immunochemical properties. Comp Biochem Physiol C Toxicol Pharmacol. Endocrinol 121: 249-265.
43. Sen A, Kirikbakan A. 2004. Biochemical characterization and distribution of glutathione S-transferases in leaping mullet (Liza saliens). Biochem (Moscow) 69: 993-1000.
44. Sen A, Sahin B, Agus HH, Bayav M, Sevim H, Semiz A. 2007. Prevention of carbon tetrachloride-induced hepatotoxicity by Urtica urens in rats. J Appl Biol Sci 1: 29-32.
45. Shimada T, Yamazaki H, Minura M, Inui Y, Guengerich FP. 1994. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270: 414-423.
46. Snyder MJ, Maddison DR. 1997. Molecular phylogeny of glutathione S-transferases. DNA Cell Biol 16: 1373-1384.
47. Strittmatter P, Velick SF. 1957. The purification and properties of microsomal cytochrome reductase. J Biol Chem 228: 785-799.
48. Tahri A, Yamani S, Legssyer A et al. 2000. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol 73: 95-100.
49. Testai L, Chericoni S, Calderone V et al. 2002. Cardiovascular effects of Urtica dioica L. (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies. J Ethnopharmacol 81: 105-109.
50. Watt JM, Breyer-Brandwijk MG. 1962. The Medicinal and Poisonous Plants of Southern and Eastern Africa, 2nd edn. Livingstone: London.
51. Waxman DJ. 1999. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR and PPAR. Arch Biochem Biophys 369: 11-23.
52. Wentworth JM, Agostini M, Love J, Schwabe JW, Chatterjee VK. 2000. St John's wort, a herbal antidepressant, activates the steroid X receptor. J Endocrinol 166: R11-R16.
53. Wilkinson J, Clapper ML. 1997. Detoxication enzymes and chemoprevention. Proc Soc Exp Biol Med 216: 192-200.
54. Zhou S, Gao Y, Jiang W, Huang M, Xu A, Paxton JW. 2003. Interactions of herbs with cytochrome P450. Drug Metab Rev 35: 35-98.