Mechanism of herpes simplex virus type 2 suppression by propolis extracts

Phytomedicine

Volumn 17, Issue 2, 2010, Pages 132-138

  Nolkemper, Silke ^a   Reichling, Jürgen ^a   Sensch, Karl Heinz ^b   Schnitzler, Paul ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Department Research and Development   (Germany)

Author keywords

Aqueous extract; Ethanolic extract; Herpes simplex virus type 2; Propolis; Virus suppression

Indexed keywords

ACICLOVIR; CARBOXYLIC ACID DERIVATIVE; FLAVONOID; POLYPHENOL; PROPOLIS;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CELL DIVISION; CELL SUSPENSION; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; IC 50; INFECTION; NONHUMAN; PHYTOCHEMISTRY; PLAQUE FORMING CELL; PRIORITY JOURNAL; VIRUS INFECTION;

ANIMALS; ANTIVIRAL AGENTS; APITHERAPY; CARBOXYLIC ACIDS; CELL CULTURE TECHNIQUES; FLAVONOIDS; HAPLORHINI; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; INHIBITORY CONCENTRATION 50; PHENOLS; PHYTOTHERAPY; PLANT EXTRACTS; PROPOLIS;

HERPES; HERPESVIRIDAE; HUMAN HERPESVIRUS 2;

EID: 73449120684     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.07.006     Document Type: Article

References (39)

1. Abd El-Hadi F.K., and Hegazi A.G. Egyptian propolis: 2. Chemical composition, antiviral and antimicrobial activities of East Nile Delta propolis. Zeitschrift für Naturforschung 57c (2002) 386-394
2. Al-Waili N.S. Clinical and mycological benefits of topical application of honey, olive oil and beeswax in diaper dermatitis. Clin. Microbiol. Inf. 11 (2005) 160-163
3. Amoros M., Sauvager F., Girre L., and Cormier M. In vitro antiviral activity of propolis. Apidologie 23 (1992) 231-240
4. Amoros M., Simoes C.M.O., Girre L., Sauvager F., and Cormier M. Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture: comparison with the antiviral activity of propolis. J. Nat. Prod. 55 (1992) 1732-1740
5. Amoros M., Lurton E., Boustie J., Girre L., Sauvager F., and Cormier M. Comparison of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-enyl caffeate. J. Nat. Prod. 57 (1994) 644-647
6. Bankova V., Christov R., Kujumgiev A., Marcucci M.C., and Popov S. Chemical composition and antibacterial activity of Brazilian propolis Z. Naturforsch 50c (1995) 167-172
7. Banskota A.H., Tezuka Y.T., and Kadota S. Recent progress in pharmacological research of propolis. Phytother. Res. 15 (2001) 561-571
8. Borrelli F., Maffia P., Pinto L., Ianaro A., Russo A., Capasso F., and Ialenti A. Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia 73 Suppl. 1 (2002) S53-S63
9. Boyanova L., Gergova G., Nikolov R., Derejian S., Lazarova E., Katsarov N., Mitov I., and Krastev Z. Activity of Bulgarian propolis against 94 Helicobacter pylori strains in vitro by agar-well diffusion, agar dilution and disc diffusion methods. J. Med. Microbiol. 54 (2005) 481-483
10. Cohen H.A., Varsano I., Kahan E., Sarrell E., and Uziel Y. Effectiveness of an herbal preparation containing Echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study. Arch. Ped. Adolesc. Med. 158 (2004) 217-221
11. Debiaggi M., Tateo F., Pagani L., Luini M., and Romero E. Effects of propolis flavonoids on virus infectivity and replication. Microbiologica 13 (1990) 207-213
12. De Clercq E. Antiviral drugs in current clinical use. J. Clin. Virol. 30 (2004) 115-133
13. El-khawaga O.-A.Y., Salem T.A., and Elshal M.F. Protective role of Egyptian propolis against tumor in mice. Clin. Chim. Acta 338 (2003) 11-16
14. Fleming D.T., McQuillan G.M., Johnson R.E., Nahmins A.J., Aral S.O., Lee F.K., and St Louis M.E. Herpes simplex virus type 2 in the United States, 1976 to 1994. N. Engl. J. Med. 337 (1997) 1105-1111
15. Ghisalberti E.L. Propolis: a review. Bee World 60 (1979) 59-84
16. Gonzales R., Corcho I., Remirez D., et al. Hepatoprotective effects of propolis extract on carbon tetrachloride-induced liver injury in rats. Phytother. Res. 9 (1995) 14-17
17. Huleihel M., and Isanu V. Anti-herpes simplex virus effect of an aqueous extract of propolis. Isr. Med. Ass. J. 4 (2002) 923-927
18. Howard M., Sellors J.W., Jang D., Robinson N.J., Fearon M., Kaczorowski J., and Chernesky M. Regional distribution of antibodies to herpes simplex virus type 1 (HSV-1) and HSV-2 in men and women in Ontario, Canada. J. Clin. Microbiol. 41 (2003) 84-89
19. Ito J., Chang F.-R., Wang H.-K., Park Y.K., Ikegaki M., Kilgore N., and Lee K.-H. Anti-AIDS agents 48: anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis. J. Nat. Prod. 64 (2001) 1278-1281
20. Kartal M., Yildiz S., Kaya S., Kurucu S., and Topcu G. Antimicrobial activity of propolis samples from two different regions of Anatolia. J. Ethnopharmacol. 56 (2003) 69-73
21. Koch C., Reichling J., Schneele J., and Schnitzler P. Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine 15 (2008) 71-78
22. Koelle D.M., and Wald A. Herpes simplex virus: the importance of asymptomtic shedding. J. Antimicrob. Chemother. 45 Suppl. (2000) 1-8
23. Koo H., Gomes B.P.F.A., Rosalen P.L., Ambrosano G.M.B., Park Y.K., and Cury J.A. In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens. Arch. Oral Biol. 45 (2000) 141-148
24. Kujumgiev A., Svetkova I., Serkedjieva Y., Bankova V., Christov R., and Popov S. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. J. Ethnopharmacol. 64 (1999) 235-240
25. Marcucci M.C. Propolis: chemical composition, biological properties and therapeutical activity. Apidologie 26 (1995) 83-99
26. Nakajima Y., Shimazawa M., Mishima S., and Hara H. Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions. Life Sci. 80 (2007) 370-377
27. Popova M., Silici S., Kaftanoglu O., and Bankova V. Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition. Phytomedicine 12 (2005) 221-228
28. Roizman, B., Sears, A.E., 1995. Herpes simplex viruses and their replication. In: Fields, B.N., Knipe, D.M., Howley, P.M. (Eds.), Fields Virology. third ed., vol. 2. Lippincott-Raven, Philadelphia, pp. 2231-2295.
29. Russo A., Longo R., and Vanella A. Antioxidant activity of propolis: role of caffeic acid and phenethyl ester and galangin. Fitoterapia 73 Suppl. 1 (2002) S21-29
30. Scheller S., Dworniczak S., Waldemar-Klimmek K., Rajca M., Tomczyk A., and Shani J. Synergism between ethanolic extract of propolis (EEP) and anti-tuberculosis drugs on growth of mycobacteria. Z. Naturforsch. 54c (1999) 549-553
31. Schnitzler P., Koch C., and Reichling J. Susceptibility of drug-resistant clinical HSV-1 strains to essential oils of ginger, thyme, hyssop and sandalwood. Antimicrob. Agents Chemother. 51 (2007) 1859-1862
32. Schnitzler, P., Neuner, A., Nolkemper, S., Zundel, C., Nowack, H., Sensch, K.H., Reichling, J., 2009. Antiviral activity and mode of action of propolis extracts and selected compounds. Phytother. Res. in press.
33. Serkedjieva J., Manolova N., and Bankova V. Anti-influenza virus effect of some propolis constituents and their analogues (esters of substituted cinnamic acids). J. Nat. Prod. 55 (1992) 294-297
34. Smith J.S., and Robinson N.J. Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review. J. Infect. Dis. 186 Suppl. (2002) 3-28
35. Söderberg T., Johannson A., and Gref R. Toxic effects of some conifer resin acids and tea tree oil on human epithelial and fibroblast cells. Toxicology 107 (1996) 99-109
36. Sucato G., Wald A., Wakabayashi E., Vieira J., and Corey L. Evidence of latency and reactivation of both herpes simplex virus (HSV)-1 and HSV-2 in the genital region. J. Infect. Dis. 177 (1998) 1069-1072
37. Takaisi-Kikuni N.B., and Schilcher H. Electron microscopic and microcalorimetric investigations of the possible mechanism of the antibacterial action of a defined propolis provenance. Planta. Med. 60 (1994) 222-227
38. Vynograd N., Vynograd I., and Sosnowski Z. A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV). Phytomedicine 7 (2000) 1-6
39. Wald A., Zeh J., Selke S., Ashley R.L., and Corey L. Virological characteristics of subclinical and symptomatic genital herpes infections. N. Engl. J. Med. 333 (1995) 770-775