Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells

Toxicology and Applied Pharmacology

Volumn 242, Issue 3, 2010, Pages 281-289

  Asp, Vendela ^a   Ullerås, Erik ^b   Lindström, Veronica ^a   Bergström, Ulrika ^a   Oskarsson, Agneta ^b   Brandt, Ingvar ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Adrenocortical cancer (ACC); Adrenocorticolytic DDT metabolites; Biphasic responses; Endocrine disruption; H295R; Steroidogenesis

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 3 METHYLSULFONYL 1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN II; ANTINEOPLASTIC AGENT; CYTOCHROME P450; CYTOCHROME P450 11B1; ETOMIDATE; FORSKOLIN; HYDROCORTISONE; MESSENGER RNA; MITOTANE; STEROID 21 MONOOXYGENASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UNCLASSIFIED DRUG;

ADRENAL CORTEX CARCINOMA; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SENSITIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HORMONE RESPONSE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SPECIES DIFFERENCE;

ADRENAL CORTEX; ADRENAL GLAND NEOPLASMS; ALDOSTERONE; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CELL LINE; DDT; DICHLORODIPHENYL DICHLOROETHYLENE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; HYDROCORTISONE; MICE; RNA, MESSENGER; SPECIES SPECIFICITY;

ANIMALIA; MURINAE; MUS;

EID: 73449118537     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.10.018     Document Type: Article

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