Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules

Archives of Toxicology

Volumn 83, Issue 4, 2009, Pages 389-396

  Asp, Vendela ^a   Lindström, Veronica ^a   Olsson, Jan A ^a   Bergström, Ulrika ^a   Brandt, Ingvar ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Adrenal cortex; Corticosterone; CYP11B1; DDE; Metabolic activation; Toxicity

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 3 METHYLSULFONYL 1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; CORTICOSTERONE; CYTOCHROME P450 11B1; DRUG METABOLITE; ETOMIDATE; MESYLIC ACID DERIVATIVE; MITOCHONDRIAL ENZYME; UNCLASSIFIED DRUG;

ADRENAL CORTEX CELL; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CORTICOSTERONE RELEASE; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADRENAL CORTEX; ANIMALS; CELL LINE; CELL SURVIVAL; CORTICOSTERONE; DICHLORODIPHENYL DICHLOROETHYLENE; DRUG ANTAGONISM; ENVIRONMENTAL POLLUTANTS; ENZYME INHIBITORS; ETOMIDATE; FORMAZANS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; STEROID 11-BETA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLIUM SALTS;

ANIMALIA;

EID: 64249088789     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0342-6     Document Type: Article

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