Cyclooxygenase-2 derived thromboxane A2 and reactive oxygen species mediate flow-induced constrictions of venules in hyperhomocysteinemia

Atherosclerosis

Volumn 208, Issue 1, 2010, Pages 43-49

  Racz, Anita ^a   Veresh, Zoltan ^a,b   Lotz, Gabor ^a   Bagi, Zsolt ^b   Koller, Akos ^a,b,c  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Cyclooxygenase 1 and 2; Flow induced constriction; HHcy; Oxidative stress; Thromboxane A2; Venules

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; CATALASE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ETHIDIUM BROMIDE; INDOMETACIN; METHIONINE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR BLOCKING AGENT;

ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FLUORESCENCE; GRACILIS MUSCLE; HYPERHOMOCYSTEINEMIA; HYPOTHESIS; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SHEAR STRESS; SKELETAL MUSCLE; THROMBOGENESIS; THROMBOSIS; VASCULAR RESISTANCE; VASODILATATION; VEIN DIAMETER; VENOCONSTRICTION; VENOUS CIRCULATION; VENULE;

ANIMALS; CYCLOOXYGENASE 2; HYPERHOMOCYSTEINEMIA; MALE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REGIONAL BLOOD FLOW; THROMBOXANE A2; VASOCONSTRICTION; VENULES;

EID: 73449106061     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.06.014     Document Type: Article

References (41)

1. Cattaneo M. Hyperhomocysteinemia, atherosclerosis and thrombosis. Thromb Haemost 81 (1999) 165-176
2. den Heijer M., Koster T., Blom H.J., et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 334 (1996) 759-762
3. Nygard O., Nordrehaug J.E., Refsum H., et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337 (1997) 230-236
4. Austin R.C., Lentz S.R., and Werstuck G.H. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ 11 Suppl. 1 (2004) S56-S64
5. McCully K.S. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 56 (1969) 111-128
6. Ungvari Z., Csiszar A., Bagi Z., and Koller A. Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation. Am J Pathol 161 (2002) 145-153
7. Fryer R.H., Wilson B.D., Gubler D.B., Fitzgerald L.A., and Rodgers G.M. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler Thromb 13 (1993) 1327-1333
8. Lentz S.R., and Sadler J.E. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest 88 (1991) 1906-1914
9. Cantu C., Alonso E., Jara A., et al. Hyperhomocysteinemia, low folate and vitamin B12 concentrations, and methylene tetrahydrofolate reductase mutation in cerebral venous thrombosis. Stroke 35 (2004) 1790-1794
10. Kanbay M., Karakus S., and Yilmaz U. Portal vein thrombosis due to hyperhomocysteinemia caused by vitamin B-12 deficiency. Dig Dis Sci 50 (2005) 2362-2363
11. Starakis I., Mougiou A., Leonidou L., Siagris D., and Karatza C. Splenic thrombosis in three patients with moderate hyperhomocysteinemia, low folate and the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene. Thromb Haemost 94 (2005) 1333-1334
12. Blondel J., Glacet-Bernard A., Bayani N., et al. Retinal vein occlusion and hyperhomocysteinemia. J Fr Ophtalmol 26 (2003) 249-253
13. Ungvari Z., Sarkadi-Nagy E., Bagi Z., Szollar L., and Koller A. Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia. Arterioscler Thromb Vasc Biol 20 (2000) 1203-1208
14. Kuo L., Arko F., Chilian W.M., and Davis M.J. Coronary venular responses to flow and pressure. Circ Res 72 (1993) 607-615
15. Koller A., Dornyei G., and Kaley G. Flow-induced responses in skeletal muscle venules: modulation by nitric oxide and prostaglandins. Am J Physiol 275 (1998) H831-836
16. Racz A., Toth E., Veresh Z., Toth J., and Koller A. Increased role of prostaglandin H-2/thromboxane A(2) (PGH(2)/TXA(2)) in mediation of flow dependent responses of gracilis muscle venules in hyperhomocysteinemia (HHcy). FASEB J 21 (2007) A846-a847
17. Bagi Z., Ungvari Z., and Koller A. Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite. Arterioscler Thromb Vasc Biol 22 (2002) 28-33
18. Ungvari Z., Csiszar A., Edwards J.G., et al. Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase. Arterioscler Thromb Vasc Biol 23 (2003) 418-424
19. Davi G., Di Minno G., Coppola A., et al. Oxidative stress and platelet activation in homozygous homocystinuria. Circulation 104 (2001) 1124-1128
20. Huang A., Sun D., Koller A., and Kaley G. Gender difference in flow-induced dilation and regulation of shear stress: role of estrogen and nitric oxide. Am J Physiol 275 (1998) R1571-1577
21. Huang A., Sun D., Kaley G., and Koller A. Estrogen preserves regulation of shear stress by nitric oxide in arterioles of female hypertensive rats. Hypertension 31 (1998) 309-314
22. Cattaneo M. Hyperhomocysteinemia and venous thromboembolism. Semin Thromb Hemost 32 (2006) 716-723
23. Robinson K., Arheart K., Refsum H., et al. Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. Circulation 97 (1998) 437-443
24. Selhub J. Homocysteine metabolism. Annu Rev Nutr 19 (1999) 217-246
25. Hirsch S., Ronco A.M., Pinardi G., et al. Lack of effect of diet-induced hypomethylation on endothelium-dependent relaxation in rats. Clin Nutr 27 (2008) 895-899
26. Blobaum A.L., and Marnett L.J. Structural and functional basis of cyclooxygenase inhibition. J Med Chem 50 (2007) 1425-1441
27. Bagi Z., Koller A., and Kaley G. Superoxide-NO interaction decreases flow- and agonist-induced dilations of coronary arterioles in Type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol 285 (2003) H1404-H1410
28. Kanani P.M., Sinkey C.A., Browning R.L., et al. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation 100 (1999) 1161-1168
29. Misra H.P. Generation of superoxide free radical during the autooxidation of thiols. J Biol Chem 249 (1974) 2151-2155
30. Weiss N. Mechanisms of increased vascular oxidant stress in hyperhomocys-teinemia and its impact on endothelial function. Curr Drug Metab 6 (2005) 27-36
31. Goetschkes T., Toth J., Debreczeni B., Tamas R., and Koller A. Hydrogen peroxide elicits prostaglandins-mediated constriction of isolated skeletal muscle venules. FASEB J. 20 (2006) A1400
32. Armstead W.M., Mirro R., Busija D.W., and Leffler C.W. Postischemic generation of superoxide anion by newborn pig brain. Am J Physiol 255 (1988) H401-H403
33. Kukreja R.C., Kontos H.A., Hess M.L., and Ellis E.F. PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH. Circ Res 59 (1986) 612-619
34. Outinen P.A., Sood S.K., Liaw P.C., et al. Characterization of the stress-inducing effects of homocysteine. Biochem J 332 Pt 1 (1998) 213-221
35. Yamamoto M., Hara H., and Adachi T. Effects of homocysteine on the binding of extracellular-superoxide dismutase to the endothelial cell surface. FEBS Lett 486 (2000) 159-162
36. Starkebaum G., and Harlan J.M. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest 77 (1986) 1370-1376
37. Lentz S.R., Sobey C.G., Piegors D.J., et al. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest 98 (1996) 24-29
38. Durand P., Lussier-Cacan S., and Blache D. Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats. FASEB J 11 (1997) 1157-1168
39. Constans J., Blann A.D., Resplandy F., et al. Endothelial dysfunction during acute methionine load in hyperhomocysteinaemic patients. Atherosclerosis 147 (1999) 411-413
40. Harker L.A., Ross R., Slichter S.J., and Scott C.R. Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis. J Clin Invest 58 (1976) 731-741
41. Surtees R., Leonard J., and Austin S. Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. Lancet 338 (1991) 1550-1554