A contemporary review of wound healing in otolaryngology: Current state and future promise

Laryngoscope

Volumn 119, Issue 11, 2009, Pages 2099-2110

  Hom, David B ^a   Sun, Gordon H ^a   Elluru, Ravindhra G ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Facial allotransplantation; Growth factor; Subglottic healing; Wound healing

Indexed keywords

AZATHIOPRINE; BECAPLERMIN; BEVACIZUMAB; BONE MORPHOGENETIC PROTEIN 2; CYCLOSPORIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 10; INTERLEUKIN 1BETA; JUVISTA; METALLOPROTEINASE; METHYLPREDNISOLONE; PALIFERMIN; PLATELET DERIVED GROWTH FACTOR AA; PREDNISONE; RECOMBINANT PLATELET DERIVED GROWTH FACTOR; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA3; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG; VASCULOTROPIN; VELAFERMIN;

ALLOTRANSPLANTATION; ANGIOGENESIS; BIOENGINEERING; BLEEDING; CLINICAL TRIAL; DEBRIDEMENT; ECCHYMOSIS; EDEMA; ENDOTRACHEAL INTUBATION; FACIAL TRANSPLANTATION; GRAFT REJECTION; GRANULATION TISSUE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION CONTROL; INJURY; METASTASIS; MUCOSA INFLAMMATION; NONHUMAN; NUTRITION; ORAL MUCOSITIS; OTORHINOLARYNGOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SCAR; SKIN GRAFT; SKIN INJURY; SKIN TRANSPLANTATION; SOFT TISSUE; SUBGLOTTIC MUCOSA INJURY; SUBGLOTTIS TRANSPLANTATION; THROMBOCYTE RICH PLASMA; TRANSPLANTATION; ULCER; VACUUM ASSISTED CLOSURE; WOUND; WOUND CARE; WOUND DRESSING; WOUND HEALING; WOUND HEALING IMPAIRMENT;

FACIAL TRANSPLANTATION; FORECASTING; GLOTTIS; HUMANS; LARYNGEAL MUCOSA; OTOLARYNGOLOGY; SKIN PHYSIOLOGICAL PHENOMENA; WOUND HEALING;

EID: 73449097848     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1002/lary.20561     Document Type: Review

References (95)

1. Winter G. Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig. Nature 1962;193:293-294.
2. Spielberger R, Stiff P, Bensinger W, et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 2004;351:2590-2598.
3. Schultz GS, Sibbald RG, Falanga V, et al. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen 2003;11:S1-S28.
4. Mast B, Schultz G. Interactions of cytokines, growth factors and proteases in acute and chronic wounds. Wound Repair Regen 1996;4:411-420.
5. Hom DB, Adams G, Koreis M, Maisel R. Choosing the optimal wound dressing for irradiated soft tissue wounds. Otolaryngol Head Neck Surg 1999;121:591-598.
6. Rijswijk LV. Wound assessment and documentation. In: Krasner DK, Rodeheaver GT, Sibbald RG, eds. Chronic Wound Care: A Clinical Source book for Healthcare Professionals. Wayne, PA: HMP Communications; 2001:101-115.
7. Schuster R, Moradzadeh A, Waxman K. The use of vacuum-assisted closure therapy for the treatment of a large infected facial wound. Am Surg 2006;72:129-131.
8. Argenta L, Molnar J, Stoeckel W. Vacuum assisted devices for difficult wounds of the face and neck. In: Hom DB, Hebda P, Gosain A, Friedman C, eds. Essential Tissue Healing of the Face and Neck. Hamilton, Ontario, Canada: BC Decker, Inc.; 2009.
9. Wieman T. Clinical efficacy of becaplermin (rhPDGF-BB) gel. Am J Surg 1998;176:74S-79S.
10. Lynch S, Nixon J, Colvin R, et al. Role of platelet-derived growth factors in wound healing synergistic effects with other growth factors. Proc Natl Acad Sci U.S.A 1987;84: 7696-7700.
11. Steed D, Group DU. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers. J Vasc Surg 1995;21: 71-81.
12. Wollina U, Liebold K, Konrad H. Treatment of chronic radiation ulcers with recombinant platelet-derived growth factor and a hydrophilic copolymer membrane. J Eur Acad Dermatol Venereol 2001;15:455-457.
13. Hom DB, Manivel JC. Promoting healing with recombinant human platelet-derived growth factor - BB in a previously irradiated problem wound. Laryngoscope 2003;113:1566-1571.
14. Jakubowicz DM, Smith RV. Use of becaplermin in the closure of pharyngocutaneous fistulas. Head Neck 2005;27: 433-438.
15. Steed D, Donohoe D, Webster M. Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. J Am Coll Surg 1996;183:61-64.
16. Regranex [revised package insert]. Raritan, NJ: Ortho-McNeil Co., division of Ortho-McNeil-Janssen Pharmaceutics Inc; 2008.
17. Powell DM, Chang E, Farrior EH. Recovery from deep-plane rhytidectomy following unilateral wound treatment with autologous platelet gel: a pilot study. Arch Facial Plast Surg 2001;3:245-250.
18. Crovetti G, Martinelli G, Issi M, et al. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci 2004; 30:145-151.
19. Mazzucco L, Medici D, Serra M, et al. The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study. Transfusion 2004;44:1013-1018.
20. Kitoh H, Kitakoji T, Tsuchiya H, et al. Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis - a preliminary result of three cases. Bone 2004;35:892-898.
21. Mogan C, Larson DF. Rationale of platelet gel to augment adaptive remodeling of the injured heart. J Extra Corpor Technol 2004;36:191-196.
22. Brisset A, Hom D. The effects of tissue sealants, platelet gels, and growth factors on wound healing. Curr Opin Otolaryngol Head Neck Surg 2003;11:245-250.
23. Brown SA, Appelt EA, Lipschitz A, Sorokin ES, Rohrich RJ. Platelet gel sealant use in rhytidectomy. Plast Reconstr Surg 2006;118:1019-1025.
24. Waters JH, Roberts KC. Database review of possible factors influencing point-of-care platelet gel manufacture. J Extra Corpor Technol 2004;36:250-254.
25. Pomerantz J, Dutton JM. Platelet gel for endoscopic sinus surgery. Ann Otol Rhinol Laryngol 2005;114:699-704.
26. Vick VL, Holds JB, Hartstein ME, Rich RM, Davidson BR. Use of autologous platelet concentrate in blepharoplasty surgery. Ophthal Plast Reconstr Surg 2006;22:102-104.
27. Hom DB, Linzie BM, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg 2007;9:174-183.
28. Margolis D, Kantor J, Santanna J, Strom B, Berlin J. Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Diabetes Care 2001;24:483-488.
29. Robson M, Mustoe T, Hunt T. The future of recombinant growth factors in wound healing. Am J Surg 1998;176: 80S-82S.
30. Robson MC, Phillips TJ, Falanga V, et al. Randomized trial of topically applied repifermin (recombinant human keratinocyte growth factor-2) to accelerate wound healing in venous ulcers. Wound Repair Regen 2001;9:347-352.
31. Weber RS, Callender DL. Antibiotic prophylaxis in clean-contaminated head and neck oncologic surgery. Ann Otol Rhinol Laryngol Suppl 1992;155:16-20.
32. Heinzerling JH, Huerta S. Bowel perforation from bevacizumab for the treatment of metastatic colon cancer: incidence, etiology, and management. Curr Surg 2006;63:334-337.
33. Burkart C, Grisel J, Hom D. Spontaneous nasal septal perforation with anti-angiogenic bevacizumab therapy. Laryngoscope 2008;118:1539-1541.
34. Tucker GF Jr, Newton L, Ruben RJ. Histopathology of acquired subglottic stenosis. A documented case report. Ann Otol Rhinol Laryngol 1981;90:335-338.
35. Tucker GF, Ossoff RH, Newman AN, Holinger LD. Histopathology of congenital subglottic stenosis. Laryngoscope 1979;89:866-877.
36. Walner DL, Loewen MS, Kimura RE. Neonatal subglottic stenosis - incidence and trends. Laryngoscope 2001;111:48-51.
37. Weymuller EA Jr, Bishop MJ, Fink BR, Hibbard AW, Spelman FA. Quantification of intralaryngeal pressure exerted by endotracheal tubes. Ann Otol Rhinol Laryngol 1983;92:444-447.
38. Albert DM, Mills RP, Fysh J, Gamsu H, Thomas JN. Endoscopic examination of the neonatal larynx at extubation: a prospective study of variables associated with laryngeal damage. Int J Pediatr Otorhinolaryngol 1990;20:203-212.
39. Downing GJ, Kilbride HW. Evaluation of airway complications in high-risk preterm infants: application of flexible fiberoptic airway endoscopy. Pediatrics 1995;95:567-572.
40. Contencin P, Narcy P. Size of endotracheal tube and neonatal acquired subglottic stenosis. Study Group for Neonatology and Pediatric Emergencies in the Parisian Area. Arch Otolaryngol Head Neck Surg 1993;119:815-819.
41. Grundfast KM, Camilon FS Jr, Pransky S, Barber CS, Fink R. Prospective study of subglottic stenosis in intubated neonates. Ann Otol Rhinol Laryngol 1990;99:390-395.
42. Dankle SK, Schuller DE, McClead RE. Risk factors for neonatal acquired subglottic stenosis. Ann Otol Rhinol Laryngol 1986;95:626-630.
43. Sherman JM, Lowitt S, Stephenson C, Ironson G. Factors influencing acquired subgottic stenosis in infants. J Pediatr 1986;109:322-327.
44. Suzumura H, Nitta A, Tanaka G, Kuwashima S, Hirabayashi H. Role of infection in the development of acquired subglottic stenosis in neonates with prolonged intubation. Pediatr Int 2000;42:508-513.
45. Yamada Y, Sugai M, Woo M, Nishida N, Sugimoto T. Acquired subglottic stenosis caused by methicillin resistant Staphylococcus aureus that produce epidermal cell differentiation inhibitor. Arch Dis Child Fetal Neonatal Ed 2001;84:F38-F39.
46. Dohar JE, Klein EC, Betsch JL, Hebda PA. Acquired subglottic stenosis-depth and not extent of the insult is key. Int J Pediatr Otorhinolaryngol 1998;46:159-170.
47. Gaynor EB. Gastroesophageal reflux as an etiologic factor in laryngeal complications of intubation. Laryngoscope 1988;98:972-979.
48. Jindal JR, Milbrath MM, Shaker R, Hogan WJ, Toohill RJ. Gastroesophageal reflux disease as a likely cause of "idiopathic" subglottic stenosis. Ann Otol Rhinol Laryngol 1994;103:186-191.
49. Poetker DM, Ettema SL, Blumin JH, Toohill RJ, Merati AL. Association of airway abnormalities and risk factors in 37 subglottic stenosis patients. Otolaryngol Head Neck Surg 2006;135:434-437.
50. Walner DL, Stern Y, Gerber ME, Rudolph C, Baldwin CY, Cotton RT. Gastroesophageal reflux in patients with subglottic stenosis. Arch Otolaryngol Head Neck Surg 1998;124:551-555.
51. Yellon RF, Parameswaran M, Brandom BW. Decreasing morbidity following laryngotracheal reconstruction in children. Int J Pediatr Otorhinolaryngol 1997;41:145-154.
52. Dauer EH, Ponikau JU, Smyrk TC, Murray JA, Thompson DM. Airway manifestations of pediatric eosinophilic esophagitis: a clinical and histopathologic report of an emerging association. Ann Otol Rhinol Laryngol 2006; 115:507-517.
53. Maronian NC, Azadeh H, Waugh P, Hillel A. Association of laryngopharyngeal reflux disease and subglottic stenosis. Ann Otol Rhinol Laryngol 2001;110:606-612.
54. Valdez TA, Shapshay SM. Idiopathic subglottic stenosis revisited. Ann Otol Rhinol Laryngol 2002;111:690-695.
55. Gans R, de Vries N, Donker AJ, Goldschmeding R, Hoorntje SJ. Circulating anti-neutrophil cytoplasmic autoantibodies in subglottic stenosis: a useful aid in diagnosing vasculitis in this condition? Q J Med 1991;80:565-574.
56. Barker JH, Francois CG, Frank JM, Maldonado C. Composite tissue allotransplantation. Transplantation 2002;73:832-835.
57. Birchall MA, Lorenz RR, Berke GS, et al. Laryngeal transplantation in 2005: a review. Am J Transplant 2006;6:20-26.
58. Dubernard JM, Owen E, Herzberg G, et al. Human hand allograft: report on first 6 months. Lancet 1999;353:1315-1320.
59. Jones JW, Gruber SA, Barker JH, Breidenbach WC. Successful hand transplantation. One-year follow-up. Louisville Hand Transplant Team. N Engl J Med 2000;343:468-473.
60. Packer JD, Rodeo SA. Meniscal allograft transplantation. Clin Sports Med 2009;28:259-283,viii.
61. Sales de Gauzy J, Accadbled F, Gomez Brouchet A, Abid A. Case report: histologic study of a human epiphyseal transplant at 3 years after implantation. Clin Orthop Relat Res 2009; Feb 11 [Epub ahead of print].
62. Selvaggi G, Levi DM, Cipriani R, Sgarzani R, Pinna AD, Tzakis AG. Abdominal wall transplantation: surgical and immunologic aspects. Transplant Proc 2009;41:521-522.
63. Strome M, Stein J, Esclamado R, et al. Laryngeal transplantation and 40-month follow-up. N Engl J Med 2001;344:1676-1679.
64. Devauchelle B, Badet L, Lengele B, et al. First human face allograft: early report. Lancet 2006;368:203-209.
65. Dubernard JM, Lengele B, Morelon E, et al. Outcomes 18 months after the first human partial face transplantation. N Engl J Med 2007;357:2451-2460.
66. Guo S, Han Y, Zhang X, et al. Human facial allotransplantation: a 2-year follow-up study. Lancet 2008;372:631-638.
67. Kanitakis J, Badet L, Petruzzo P, et al. Clinicopathologic monitoring of the skin and oral mucosa of the first human face allograft: report on the first eight months. Transplantation 2006;82:1610-1615.
68. Lantieri L, Meningaud JP, Grimbert P, et al. Repair of the lower and middle parts of the face by composite tissue allotransplantation in a patient withmassive plexiform neurofibroma: a 1-year follow-up study. Lancet 2008;372:639-645.
69. Gander B, Brown CS, Vasilic D, et al. Composite tissue allotransplantation of the hand and face: a new frontier in transplant and reconstructive surgery. Transpl Int 2006; 19:868-880.
70. Thaunat O, Badet L, El-Jaafari A, Kanitakis J, Dubernard JM, Morelon E. Composite tissue allograft extends a helping hand to transplant immunologists. Am J Transplant 2006;6:2238-2242.
71. Brouha P, Naidu D, Cunningham M, et al. Risk acceptance in composite-tissue allotransplantation reconstructive procedures. Microsurgery 2006;26:144-149; discussion 149-150.
72. Brown CS, Gander B, Cunningham M, et al. Ethical considerations in face transplantation. Int J Surg 2007;5:353-364.
73. Whitaker IS, Duggan EM, Alloway RR, et al. Composite tissue allotransplantation: a review of relevant immunological issues for plastic surgeons. J Plast Reconstr Aesthet Surg 2008;61:481-492.
74. Wendt JR, Ulich T, Rao PN. Long-term survival of human skin allografts in patients with immunosuppression. Plast Reconstr Surg 2004;113:1347-1354.
75. Demir Y, Ozmen S, Klimczak A, Mukherjee AL, Siemionow M. Tolerance induction in composite facial allograft transplantation in the rat model. Plast Reconstr Surg 2004;114:1790-1801.
76. Siemionow M, Gozel-Ulusal B, Engin Ulusal A, Ozmen S, Izycki D, Zins JE. Functional tolerance following face transplantation in the rat. Transplantation 2003;75:1607-1609.
77. Siemionow MZ, Demir Y, Sari A, Klimczak A. Facial tissue allograft transplantation. Transplant Proc 2005;37:201-204.
78. Unal S, Agaoglu G, Zins J, Siemionow M. New surgical approach in facial transplantation extends survival of allograft recipients. Ann Plast Surg 2005;55:297-303.
79. Siemionow M, Agaoglu G, Unal S. A cadaver study in preparation for facial allograft transplantation in humans: part II. Mock facial transplantation. Plast Reconstr Surg 2006;117:876-885; discussion 886-878.
80. Siemionow M, Unal S, Agaoglu G, Sari A. A cadaver study in preparation for facial allograft transplantation in humans: part I. What are alternative sources for total facial defect coverage? Plast Reconstr Surg 2006;117:864-872; discussion 873-865.
81. Chua A, Song C, Chai A, Chan L, Tan KC. The impact of skin banking and the use of its cadaveric skin allografts for severe burn victims in Singapore. Burns 2004;30:696-700.
82. Swearingen B, Ravindra K, Xu H, Wu S, Breidenbach WC, Ildstad ST. Science of composite tissue allotransplantation. Transplantation 2008;86:627-635.
83. Morris P, Bradley A, Doyal L, et al. Face transplantation: a review of the technical, immunological, psychological and clinical issues with recommendations for good practice. Transplantation 2007;83:109-128.
84. Colwell AS, Beanes SR, Soo C, et al. Increased angiogenesis and expression of vascular endothelial growth factor during scarless repair. Plast Reconstr Surg 2005;115:204-212.
85. Rahbar R, Brown LF, Folkman J, et al. Role of vascular endothelial growth factor A in children with acquired airway stenosis. Ann Otol Rhinol Laryngol 2007;116:430-435.
86. Jarmuz T, Roser S, Rivera H, Gal A, Roman J. Transforming growth factor-beta1, myofibroblasts, and tissue remodeling in the pathogenesis of tracheal injury: potential role of gastroesophageal reflux. Ann Otol Rhinol Laryngol 2004;113:488-497.
87. Dillard DG, Gal AA, Roman-Rodriguez J, White S, Jacobs IN. Transforming growth factor and neutralizing antibodies in subglottic stenosis. Ann Otol Rhinol Laryngol 2001;110:393-400.
88. Martinez-Alvernia EA, Rudnick JA, Mankarious LA. Transforming growth factor beta3 increases chondrocyte proliferation and decreases apoptosis in murine cricoid cartilage in vitro. Otolaryngol Head Neck Surg 2008;138:435-440.
89. Gray T, Nettesheim P, Loftin C, et al. Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling. Mol Pharmacol 2004;66:337-346.
90. Martinez-Alvernia EA, Mankarious LA. Matrix metalloproteinases 2 and 9 are concentrated in the luminal aspect of the cricoid cartilage, diminish with loss of perichondrium, and are reinstated by transforming growth factor beta 3. Ann Otol Rhinol Laryngol 2008;117:925-930.
91. Elluru RG, Thompson F, Reece A. Fibroblast growth factor 18 gives growth and directional cues to airway cartilage. Laryngoscope 2009;119:1153-1165.
92. Tcacencu I, Carlsoo B, Stierna P. Recombinant human bone morphogenetic protein-2 enhances experimental laryngotracheal reconstruction in rabbits. Acta Otolaryngol 2004;124:612-615.
93. Tcacencu I, Carlsoo B, Stierna P. Effect of recombinant human BMP-2 on the repair of cricoid cartilage defects in young and adult rabbits: a comparative study. Int J Pediatr Otorhinolaryngol 2005;69:1239-1246.
94. McCollough E. Surgical Anatomy of the Skin and Wound Healing. In: GM E, ed. Otolaryngology. Philadelphia: Harper & Row, 1978.
95. Dhir K, Reino AJ, Lipana J. Vacuum-assisted closure therapy in the management of head and neck wounds. Laryngoscope 2009;119:54-61.