Recombinant human bone morphogenetic protein-2 enhances experimental laryngotracheal reconstruction in rabbits

Acta Oto-Laryngologica

Volumn 124, Issue 5, 2004, Pages 612-615

  Tcacencu, Ion ^a   Carlsöö, Bengt ^a   Stierna, Pontus ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Airway; Cartilage; Epithelium; Growth factor; Wound healing

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; RECOMBINANT PROTEIN;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRICOID; DRUG DELIVERY SYSTEM; DRUG EFFECT; INTERMETHOD COMPARISON; LARYNGOPLASTY; LARYNX INJURY; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RABBIT; RANDOMIZATION; REGENERATION; RESPIRATORY EPITHELIUM; TIME SERIES ANALYSIS; TRACHEA RECONSTRUCTION; WOUND HEALING;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CRICOID CARTILAGE; MALE; MODELS, ANIMAL; RABBITS; RANDOM ALLOCATION; RECOMBINANT PROTEINS; REGENERATION; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 3042742677     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016480310015696     Document Type: Article

References (20)

1. Verwoerd-Verhoef HL, ten Koppel PG, van Osch GJ, Meeuwis CA, Verwoerd CD. Wound healing of cartilage structures in the head and neck region. Int J Pediatr Otorhinolaryngol 1998; 43: 241-51.
2. Sakon T. Bone morphogenetic proteins: from basic studies to clinical approaches. Bone 1998; 22: 591-603.
3. Reddi AH. Bone and cartilage differentiation. Curr Opin Genet Dev 1994; 4: 737-44.
4. Duprez DM, Coltey M, Amthoz H, Brickell PM, Tickle C. Bone morphogenetic protein-2 (BMP-2) inhibits muscle development and promotes cartilage formation in chick limb and cultures. Dev Biol 1996; 174: 448-52.
5. Sellers RS, Peluso D, Morris EA. The effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the healing of full-thickness defects of articular cartilage. J Bone Joint Surg Am 1997; 79: 1452-63.
6. Walner DL, Cotton RT, Willging JP, Bove KE, Toriumi DM. Model for evaluating the effect of growth factors on the larynx. Otolaryngol Head Neck Surg 1999; 120: 78-83.
7. Ma S, Chen G, Reddi AH. Collaboration between collagenous matrix and osteogenin is required for bone induction. Ann N Y Acad Sci 1990; 580: 524-5.
8. McPherson JM. The utility of collagen-based vehicles in delivery of growth factors for hard and soft tissue wound repair. Clin Mater 1992; 9: 225-34.
9. Hollinger JO, Uludag H, Winn SR. Sustained release emphasising recombinant human bone morphogenetic protein-2. Adv Drug Del Rev 1998; 31: 303-18.
10. Uludag H, D'Augusta D, Palmer R, Timony G, Wozney J. Characterisation of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model. J Biomed Mater Res 1999; 46: 193-202.
11. Uludag H, D'Augusta D, Golden J, et al. Implantation of recombinant human bone morphogenetic proteins with biomaterial carriers: a correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model. J Biomed Mater Res 2000; 50: 227-38.
12. Alam I, Asahina I, Ohmamiuda K, Takahashi K, Yokota S, Enomoto S. Evaluation of ceramics composed of different hydroxyapatite to tricalcium phosphate ratios as carriers for rhBMP-2. Biomaterials 2001; 22: 1643-51.
13. Sellers RS, Zhang R, Glasson SS, et al. Repair of articular cartilage defects one year after treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). J Bone Joint Surg Am 2000; 82: 151-60.
14. Sung SW, Won T. Effects of basic fibroblast growth factor on early revascularization and epithelial regeneration in rabbit tracheal orthotopic transplantation. Eur J Cardiothorac Surg 2001; 19: 14-8.
15. Loewen MS, Walner DL, Caldarelli DD. Improved airway healing using transforming growth factor beta-3 in a rabbit model. Wound Repair Regen 2001; 9: 44-9.
16. Zahm JM, Debordeaux C, Raby B, Klossek JM, Bonnet N, Puchelle E. Mitogenic effect of recombinant HGF on airway epithelial cells during the in vitro wound repair of the respiratory epithelium. J Cell Physiol 2000; 185: 447-53.
17. Katic V, Majstorovic L, Maticic D, et al. Biological repair of thyroid cartilage defects by osteogenic protein-1 (bone morphogenetic protein-7) in dog. Growth Factors 2000; 17: 221-32.
18. Samadi DS, Jacobs IN, Walsh D, Bouchard S, Herlyn M, Crombleholme TM. Adenovirus-mediated ex vivo gene transfer of human vascular endothelial growth factor in a rabbit laryngotracheal reconstruction model. Ann Otol Rhinol Laryngol 2002; 111: 295-301.
19. van den Berg WB, van der Kraan PM, Scharstuhl A, van Beuningen HM. Growth factors and cartilage repair. Clin Orthop 2001; Suppl 391: S244-50.
20. Hicks Jr W, Sigurdson L, Gabalski E, et al. Does cartilage down-regulate growth factor expression in tracheal epithelium? Arch Otolaryngol Head Neck Surg 1999; 125: 1239-43.