Complement gene expression in human cardiac allograft biopsies as a correlate of histologic grade of injury

Transplantation

Volumn 86, Issue 9, 2008, Pages 1319-1321

  Keslar, Karen ^a   Rodriguez, E Rene ^a   Tan, Carmela D ^a   Starling, Randall C ^a   Heeger, Peter S ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Complement; Gene expression; Heart transplantation; Human

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CD3 ANTIGEN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3 RECEPTOR; COMPLEMENT COMPONENT C3A RECEPTOR; COMPLEMENT COMPONENT C5A RECEPTOR; CYCLOSPORIN; GAMMA INTERFERON; GRANZYME B; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PERFORIN; PREDNISONE; PROPERDIN; TACROLIMUS; UNCLASSIFIED DRUG; C5AR1 PROTEIN, HUMAN; COMPLEMENT; COMPLEMENT C3A RECEPTOR; COMPLEMENT RECEPTOR; GRANZYME;

ARTICLE; CARDIAC GRAFT REJECTION; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; BIOPSY; GENETICS; GRAFT REJECTION; HEART MUSCLE; HOSPITALIZATION; METABOLISM; PATHOLOGY;

ANTIGENS, CD3; BIOPSY; COMPLEMENT C3; COMPLEMENT FACTOR B; COMPLEMENT SYSTEM PROTEINS; GENE EXPRESSION; GRAFT REJECTION; GRANZYMES; HEART TRANSPLANTATION; HUMANS; INTERFERON-GAMMA; MYOCARDIUM; PERFORIN; PROPERDIN; RECEPTORS, COMPLEMENT; SEVERITY OF ILLNESS INDEX;

EID: 58149159904     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181889831     Document Type: Article

References (18)

1. Zhou W, Peng Q, Li K, et al. Role of dendritic cell synthesis of complement in the allospecific T cell response. Mol Immunol 2007; 44: 57.
2. Peng Q, Li K, PatelH, et al. Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype. J Immunol 2006; 176: 3330.
3. Heeger PS, Lalli PN, Lin F, et al. Decay-accelerating factor modulates induction of T cell immunity. J Exp Med 2005; 201: 1523.
4. Marsh JE, Farmer CK, Jurcevic S, et al. The allogeneic T and B cell response is strongly dependent on complement components C3 and C4. Transplantation 2001; 72: 1310.
5. Pratt JR, Basheer SA, Sacks SH. Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med 2002; 8: 582.
6. Lalli PN, Strainic MG, Lin F, et al. Decay accelerating factor can control T cell differentiation into IFN-gamma-producing effector cells via regulating local C5a-induced IL-12 production. J Immunol 2007; 179: 5793.
7. Farrar CA, Zhou W, Lin T, et al. Local extravascular pool of C3 is a determinant of postischemic acute renal failure. Faseb J 2006; 20: 217.
8. Zhou W, Medof ME, Heeger PS, et al. Graft-derived complement as a mediator of transplant injury. Curr Opin Immunol 2007; 19: 569.
9. Brown KM, Kondeatis E, Vaughan RW, et al. Influence of donor C3 allotype onlate renal-transplantation outcome. N Engl J Med 2006; 354: 2014.
10. Reed EF, Demetris AJ, Hammond E, et al. Acute antibody-mediated rejection of cardiac transplants. J Heart Lung Transplant 2006; 25: 153.
11. StewartS,Winters GL, Fishbein MC,etal. Revisionofthe 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 2005; 24: 1710.
12. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402.
13. Lin T, Zhou W, Farrar CA, et al. Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection. Am J Pathol 2006; 168: 1241.
14. Laudes IJ, Chu JC, Huber-Lang M, et al. Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immunol 2002; 169: 5962.
15. Selvan RS, Kapadia HB, Platt JL. Complement-induced expression of chemokine genes in endothelium: Regulation by IL-1-dependent and -independent mechanisms. J Immunol 1998; 161: 4388.
16. Sheerin NS, Zhou W, Adler S, et al. TNF-alpha regulation of C3 gene expression and protein biosynthesis in rat glomerular endothelial cells. Kidney Int 1997; 51: 703.
17. Kitano E, Kitamura H. Synthesis of factor D by gastric cancer-derived cell lines. Int Immunopharmacol 2002; 2: 843.
18. Pratt JR, Abe K, Miyazaki M, et al. In situ localization of C3 synthesis in experimental acute renal allograft rejection. Am J Pathol 2000; 157: 825.