Mapping retinal degeneration and loss-of-function in Rd-FTL mice

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 12, 2009, Pages 5955-5964

  Greferath, Ursula ^a   Goh, Hänsel Chien ^a   Chua, Pei Ying ^a   Åstrand, Elaine ^a   O'Brien, Emily Elizabeth ^a   Fletcher, Erica Lucy ^a   Murphy, Mark ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL POPULATION; CELL STIMULATION; CONTROLLED STUDY; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; PHOTORECEPTOR; PHOTOSTIMULATION; PRIORITY JOURNAL; RD FTL MOUSE; RETINA AMACRINE CELL; RETINA CONE; RETINA DEGENERATION; RETINA GANGLION CELL; RETINA ROD; RETINITIS PIGMENTOSA; ANIMAL; CELL COUNT; DISEASE MODEL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; LIGHT; MALE; METABOLISM; MOUSE MUTANT; ONCOGENE; PHOTOGRAPHY; PHOTORECEPTOR CELL; PHYSIOLOGY; TRANSGENIC MOUSE;

BETA GALACTOSIDASE;

AMACRINE CELLS; ANIMALS; BETA-GALACTOSIDASE; CELL COUNT; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENES, FOS; LIGHT; MALE; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC; PHOTOGRAPHY; PHOTORECEPTOR CELLS, VERTEBRATE; RETINAL DEGENERATION; RETINAL GANGLION CELLS; RETINITIS PIGMENTOSA;

EID: 73349101873     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3916     Document Type: Article

References (40)

1. Marc RE, Jones BW, Watt CB, Strettoi E. Neural remodeling in retinal degeneration. Prog Retin Eye Res. 2003;22:607-655.
2. Lolley RN. The rd gene defect triggers programmed rod cell death: the Proctor Lecture. Invest Ophthalmol Vis Sci. 1994;35:4182-4191.
3. McLaughlin ME, Ehrhart TL, Berson EL, Dryja TP. Mutation spectrum of the gene encoding the beta subunit of rod phosphodies-terase among patients with autosomal recessive retinitis pigmen-tosa. Proc Natl Acad Sci USA. 1995;92:3249-3253.
4. Blanks JC, Adinolfi AM, Lolley RN. Photoreceptor degeneration and synaptogenesis in retinal-degenerative (rd) mice. J Comp Neu-rol. 1974;156:95-106.
5. Jeon C-J, Strettoi E, Masland RH. The major populations of the mouse retina. J Neurosci. 1998;18:8936-8946.
6. Wilson Y, Nag N, Davern P, et al. Visualization of functionally activated circuitry in the brain. Proc Natl Acad Sci USA. 2002;99: 3252-3257.
7. Greferath U, Nag N, Zele AJ, et al. Fos-tau-LacZ mice expose light-activated pathways in the visual system. Neuroimage. 2004; 23:1027-1038.
8. Smeyne RJ, Vendrell M, Hayward M, et al. Continuous c-fos expression precedes programmed cell death in vivo. Nature. 1993; 363:166-169.
9. Hafezi F, Steinbach JP, Marti A, et al. The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med. 1997;3:346-349.
10. Rich K, Zhan Y, Blanks J. Aberrant expression of c-Fos accompanies photoreceptor cell death in the rd mouse. J Neurobiol. 1997; 32:593-612.
11. Hafezi F, Abegg M, Grimm C, et al. Retinal degeneration in the rd mouse in the absence of c-fos. Invest Ophthalmol Vis Sci. 1998; 39:2239-2244.
12. Murphy M, Greferath U, Wilson YM. A method for detecting functional activity related expression in gross brain regions, specific brain nuclei and individual neuronal cell bodies and their projections. Biol Proced Online. 2007;9:1-8.
13. Carter-Dawson LD, LaVail MM, Sidman RL. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Oph-thalmol Vis Sci. 1978;17:489-498.
14. Sarthy PV, Fu M. Transcriptional activation of an intermediate filament protein gene in mice with retinal dystrophy. DNA. 1989; 8:437-446.
15. Jimenez AJ, Garcia-Fernandez JM, Gonzalez B, Foster RG. The spatio-temporal pattern of photoreceptor degeneration in the aged rd/rd mouse retina. Cell Tissue Res. 1996;284:193-202.
16. Lin B, Masland RH, Strettoi E. Remodeling of cone photoreceptor cells after rod degeneration in rd mice. Exp Eye Res. 2009;88:589-599.
17. Witkovsky P. Dopamine and retinal function. Doc Ophthalmol. 2004;108:17-40.
18. Portera-Cailliau C, Sung CH, Nathans J, Adler R. Apoptotic photo-receptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci USA. 1994;91:974-978.
19. Carter-Dawson LD, LaVail MM. Rods and cones in the mouse retina, I: structural analysis using light and electron microscopy. J Comp Neurol. 1979;188:245-262.
20. Strettoi E, Porciatti V, Falsini B, Pignatelli V, Rossi C. Morphological and functional abnormalities in the inner retina of the rd/rd mouse. J Neurosci. 2002;22:5492-5504.
21. Marc RE, Jones BW. Retinal remodeling in inherited photoreceptor degenerations. Mol Neurobiol. 2003;28:139-147.
22. Jones BW, Watt CB, Frederick JM, et al. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol. 2003;464: 1-16.
23. Chua J, Fletcher EL, Kalloniatis M. Functional remodeling of glu-tamate receptors by inner retinal neurons occurs from an early stage of retinal degeneration.J Comp Neurol. 2009;514:473-491
24. Komeima K, Rogers BS, Lu L, Campochiaro PA. Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci USA. 2006;103:11300-11305.
25. Strettoi E, Pignatelli V, Rossi C, Porciatti V, Falsini B. Remodeling of second-order neurons in the retina of rd/rd mutant mice. Vision Res. 2003;43:867-877.
26. Pu M, Xu L, Zhang H. Visual response properties of retinal ganglion cells in the Royal College of Surgeons dystrophic rat. Invest Ophthalmol Vis Sci. 2006;47:3579-3585.
27. Stasheff SF. Emergence of sustained spontaneous hyperactivity and temporary preservation of OFF responses in ganglion cells of the retinal degeneration (rd1) mouse. JNeurophysiol. 2008;99:1408-1421.
28. Cameron MA, Pozdeyev N, Vugler AA, Cooper H, Iuvone PM, Lucas RJ. Light regulation of retinal dopamine that is independent of melanopsin phototransduction. Eur J Neurosci. 2009;29:761-767.
29. Gustincich S, Feigenspan A, Wu DK, Koopman LJ, Raviola E. Control of dopamine release in the retina: a transgenic approach to neural networks. Neuron. 1997;18:723-736.
30. -/-) mouse. Invest Ophthalmol Vis Sci. 2003;44:3526-3532.
31. Coffey PJ, Girman S, Wang SM, et al. Long-term preservation of cortically dependent visual function in RCS rats by transplantation. Nat Neurosci. 2002;5:53-56.
32. Chow AY, Pardue MT, Chow VY, et al. Implantation of silicon chip microphotodiode arrays into the cat subretinal space. IEEE Trans Neural Syst Rehabil Eng. 2001;9:86-95.
33. Chow AY, Pardue MT, Perlman JI, et al. Subretinal implantation of semiconductor-based photodiodes: durability of novel implant designs. J Rehabil Res Dev. 2002;39:313-321.
34. Humayun MS, Weiland JD, Fujii GY, et al. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vision Res. 2003;43:2573-2581.
35. Schanze T, Wilms M, Eger M, Hesse L, Eckhorn R. Activation zones in cat visual cortex evoked by electrical retina stimulation. Graefes Arch Clin Exp Ophthalmol. 2002;240:947-954.
36. Zrenner E, Miliczek KD, Gabel VP, et al. The development of subretinal microphotodiodes for replacement of degenerated pho-toreceptors. Ophthalmic Res. 1997;29:269-280.
37. LaVail MM, Unoki K, Yasumura D, Matthes MT, Yancopoulos GD, Steinberg RH. Multiple growth factors, cytokines, and neurotro-phins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci USA. 1992;89:11249-11253.
38. Okoye G, Zimmer J, Sung J, et al. Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage. J Neu-rosci. 2003;23:4164-4172.
39. Farrar GJ, Kenna PF, Humphries P. On the genetics of retinitis pigmentosa and on mutation-independent approaches to therapeutic intervention. EMBO J. 2002;21:857-864.
40. Hauswirth WW, Beaufrere L. Ocular gene therapy: quo vadis? Invest Ophthalmol Vis Sci. 2000;41:2821-2826.