메뉴 건너뛰기




Volumn 24, Issue 6, 2009, Pages 490-499

Inhibitory effects of Kampo medicine on human UGT2B7 activity

Author keywords

Drug interactions; Human liver microsomes; Inhibition; Kampo medicine; UGT

Indexed keywords

GLUCURONOSYLTRANSFERASE 2B7; KAMPO; MORPHINE; ZIDOVUDINE;

EID: 73349092459     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.24.490     Document Type: Article
Times cited : (14)

References (37)
  • 2
    • 33645126398 scopus 로고    scopus 로고
    • Inhibition of human cytochrome P450 isoforms and NADPH-CYP reductase in vitro by 15 herbal medicines, including Epimedii herba
    • Liu, K. H., Kim, M. J., Jeon, B. H., Shon, J. H., Cha, I. J., Cho, K. H., Lee, S. S. and Shin, J. G.: Inhibition of human cytochrome P450 isoforms and NADPH-CYP reductase in vitro by 15 herbal medicines, including Epimedii herba. J. Clin. Pharm. Ther., 31: 83-91 (2006).
    • (2006) J. Clin. Pharm. Ther , vol.31 , pp. 83-91
    • Liu, K.H.1    Kim, M.J.2    Jeon, B.H.3    Shon, J.H.4    Cha, I.J.5    Cho, K.H.6    Lee, S.S.7    Shin, J.G.8
  • 4
    • 0038356729 scopus 로고    scopus 로고
    • Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer
    • Mori, K., Kondo, T., Kamiyama, Y., Kano, Y. and Tominaga, K.: Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer. Cancer Chemother. Pharmacol., 51: 403-406 (2003).
    • (2003) Cancer Chemother. Pharmacol , vol.51 , pp. 403-406
    • Mori, K.1    Kondo, T.2    Kamiyama, Y.3    Kano, Y.4    Tominaga, K.5
  • 5
    • 0036428646 scopus 로고    scopus 로고
    • St John's wort (Hypericum perforatum): Drug interactions and clinical outcomes
    • Henderson, L., Yue, Q. Y., Bergquist, C., Gerden, B. and Arlett, P.: St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. Br. J. Clin. Pharmacol., 54: 349-356 (2002).
    • (2002) Br. J. Clin. Pharmacol , vol.54 , pp. 349-356
    • Henderson, L.1    Yue, Q.Y.2    Bergquist, C.3    Gerden, B.4    Arlett, P.5
  • 6
    • 0041378080 scopus 로고    scopus 로고
    • In vitro inhibitory effects of Kampo medicines on metabolic reactions catalyzed by human liver microsomes
    • Takahashi, K., Uejima, E., Morisaki, T., Takahashi, K., Kurokawa, N. and Azuma, J.: In vitro inhibitory effects of Kampo medicines on metabolic reactions catalyzed by human liver microsomes. J. Clin. Pharm. Ther., 28: 319-327 (2003).
    • (2003) J. Clin. Pharm. Ther , vol.28 , pp. 319-327
    • Takahashi, K.1    Uejima, E.2    Morisaki, T.3    Takahashi, K.4    Kurokawa, N.5    Azuma, J.6
  • 8
    • 6944221357 scopus 로고    scopus 로고
    • Drugdrug interactions for UDP-glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
    • Williams, J. A., Hyland, R., Jones, B. C., Smith, D. A., Hurst, S., Goosen, T. C., Peterkin, V., Koup, J. R. and Ball, S. E.: Drugdrug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab. Dispos., 32: 1201-1208 (2004).
    • (2004) Drug Metab. Dispos , vol.32 , pp. 1201-1208
    • Williams, J.A.1    Hyland, R.2    Jones, B.C.3    Smith, D.A.4    Hurst, S.5    Goosen, T.C.6    Peterkin, V.7    Koup, J.R.8    Ball, S.E.9
  • 11
    • 69949158570 scopus 로고    scopus 로고
    • Effects of Japanese herbal medicine, Kampo, on human UGT1A1 activity
    • Katoh, M., Yoshioka, Y., Nakagawa, N. and Yokoi, T.: Effects of Japanese herbal medicine, Kampo, on human UGT1A1 activity. Drug Metab. Pharmacokinet., 24: 226-234 (2009).
    • (2009) Drug Metab. Pharmacokinet , vol.24 , pp. 226-234
    • Katoh, M.1    Yoshioka, Y.2    Nakagawa, N.3    Yokoi, T.4
  • 12
    • 52949136927 scopus 로고    scopus 로고
    • Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood
    • Hibino, T., Yuzurihara, M., Terawaki, K., Kanno, H., Kase, Y. and Takeda, A.: Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood. J. Pharmacol. Sci., 108: 89-94 (2008).
    • (2008) J. Pharmacol. Sci , vol.108 , pp. 89-94
    • Hibino, T.1    Yuzurihara, M.2    Terawaki, K.3    Kanno, H.4    Kase, Y.5    Takeda, A.6
  • 13
    • 50049103633 scopus 로고    scopus 로고
    • Species differences in UDP-glucuronosyltransferase activities in mice and rats
    • Shiratani, H., Katoh, M., Nakajima, M. and Yokoi, T.: Species differences in UDP-glucuronosyltransferase activities in mice and rats. Drug Metab. Dispos., 36: 1745-1752 (2008).
    • (2008) Drug Metab. Dispos , vol.36 , pp. 1745-1752
    • Shiratani, H.1    Katoh, M.2    Nakajima, M.3    Yokoi, T.4
  • 14
    • 0042858542 scopus 로고    scopus 로고
    • Evaluation of 3′- azido-3′-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: Specificity and influence of the UGT2B7*2 polymorphism
    • Court, M. H., Krishnaswamy, S., Hao, Q., Duan, S. X., Patten, C. J., Von Moltke, L. L. and Greenblatt, D. J.: Evaluation of 3′- azido-3′-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism. Drug Metab. Dispos., 31: 1125-1133 (2003).
    • (2003) Drug Metab. Dispos , vol.31 , pp. 1125-1133
    • Court, M.H.1    Krishnaswamy, S.2    Hao, Q.3    Duan, S.X.4    Patten, C.J.5    von Moltke, L.L.6    Greenblatt, D.J.7
  • 15
    • 0031894377 scopus 로고    scopus 로고
    • The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268)
    • Coffman, B. L., King, C. D., Rios, G. R. and Tephly, T. R.: The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268). Drug Metab. Dispos., 26: 73-77 (1998).
    • (1998) Drug Metab. Dispos , vol.26 , pp. 73-77
    • Coffman, B.L.1    King, C.D.2    Rios, G.R.3    Tephly, T.R.4
  • 16
    • 27544506707 scopus 로고    scopus 로고
    • Altered AZT (3′-azido-3′-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: Comparison to hepatocytes and effect of incubation environment
    • Engtrakul, J. J., Foti, R. S., Strelevitz, T. J. and Fisher, M. B.: Altered AZT (3′-azido-3′-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: comparison to hepatocytes and effect of incubation environment. Drug Metab. Dispos., 33: 1621-1627 (2005).
    • (2005) Drug Metab. Dispos , vol.33 , pp. 1621-1627
    • Engtrakul, J.J.1    Foti, R.S.2    Strelevitz, T.J.3    Fisher, M.B.4
  • 17
    • 0030879284 scopus 로고    scopus 로고
    • Plasma morphine and glucuronide (M3G and M6G) concentrations in hospice inpatients
    • Ashby, M., Fleming, B., Wood, M. and Somogyi, A.: Plasma morphine and glucuronide (M3G and M6G) concentrations in hospice inpatients. J. Pain Symptom Manage., 14: 157-167 (1997).
    • (1997) J. Pain Symptom Manage , vol.14 , pp. 157-167
    • Ashby, M.1    Fleming, B.2    Wood, M.3    Somogyi, A.4
  • 18
    • 0030069046 scopus 로고    scopus 로고
    • Atovaquone inhibits the glucuronidation and increases the plasma concentrations of zidovudine
    • Lee, B. L., Tauber, M. G., Sadler, B., Goldstein, D. and Chambers, H. F.: Atovaquone inhibits the glucuronidation and increases the plasma concentrations of zidovudine. Clin. Pharmacol. Ther., 59: 14-21 (1996).
    • (1996) Clin. Pharmacol. Ther , vol.59 , pp. 14-21
    • Lee, B.L.1    Tauber, M.G.2    Sadler, B.3    Goldstein, D.4    Chambers, H.F.5
  • 19
    • 33846435706 scopus 로고    scopus 로고
    • The in vitro drug interaction potential of dietary supplements containing multiple herbal components
    • Foti, R. S., Wahlstrom, J. L. and Wienkers, L. C.: The in vitro drug interaction potential of dietary supplements containing multiple herbal components. Drug Metab. Dispos., 35: 185-188 (2007).
    • (2007) Drug Metab. Dispos , vol.35 , pp. 185-188
    • Foti, R.S.1    Wahlstrom, J.L.2    Wienkers, L.C.3
  • 20
    • 0042679455 scopus 로고    scopus 로고
    • Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: Evidence for atypical glucuronidation kinetics by UGT2B7
    • Stone, A. N., Mackenzie, P. I., Galetin, A., Houston, J. B. and Miners, J. O.: Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7. Drug Metab. Dispos., 31: 1086-1089 (2003).
    • (2003) Drug Metab. Dispos , vol.31 , pp. 1086-1089
    • Stone, A.N.1    Mackenzie, P.I.2    Galetin, A.3    Houston, J.B.4    Miners, J.O.5
  • 21
    • 33746046061 scopus 로고    scopus 로고
    • Inhibition of UDP glucuronosyltransferase 2B7-catalyzed morphine glucuronidation by ketoconazole: Dual mechanisms involving a novel noncompetitive mode
    • Takeda, S., Kitajima, Y., Ishii, Y., Nishimura, Y., Mackenzie, P. I., Oguri, K. and Yamada, H.: Inhibition of UDP glucuronosyltransferase 2B7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode. Drug Metab. Dispos., 34: 1277-1282 (2006).
    • (2006) Drug Metab. Dispos , vol.34 , pp. 1277-1282
    • Takeda, S.1    Kitajima, Y.2    Ishii, Y.3    Nishimura, Y.4    Mackenzie, P.I.5    Oguri, K.6    Yamada, H.7
  • 22
    • 0029063958 scopus 로고
    • Comparative effects of antifungal agents on zidovudine glucuronidation by human liver microsomes
    • Sampol, E., Lacarelle, B., Rajaonarison, J. F., Catalin, J. and Durand, A.: Comparative effects of antifungal agents on zidovudine glucuronidation by human liver microsomes. Br. J. Clin. Pharmacol., 40: 83-86 (1995).
    • (1995) Br. J. Clin. Pharmacol , vol.40 , pp. 83-86
    • Sampol, E.1    Lacarelle, B.2    Rajaonarison, J.F.3    Catalin, J.4    Durand, A.5
  • 23
    • 52949103260 scopus 로고    scopus 로고
    • Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by udp-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites
    • Uchaipichat, V., Galetin, A., Houston, J. B., Mackenzie, P. I., Williams, J. A. and Miners, J. O.: Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by udp-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites. Mol. Pharmacol., 74: 1152-1162 (2008).
    • (2008) Mol. Pharmacol , vol.74 , pp. 1152-1162
    • Uchaipichat, V.1    Galetin, A.2    Houston, J.B.3    Mackenzie, P.I.4    Williams, J.A.5    Miners, J.O.6
  • 24
    • 0029738663 scopus 로고    scopus 로고
    • The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine
    • Milne, R. W., Nation, R. L. and Somogyi, A. A.: The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine. Drug Metab. Rev., 28: 345-472 (1996).
    • (1996) Drug Metab. Rev , vol.28 , pp. 345-472
    • Milne, R.W.1    Nation, R.L.2    Somogyi, A.A.3
  • 25
    • 34249937715 scopus 로고    scopus 로고
    • Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine
    • Hara, Y., Nakajima, M., Miyamoto, K. and Yokoi, T.: Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine. Drug Metab. Pharmacokinet., 22: 103-112 (2007).
    • (2007) Drug Metab. Pharmacokinet , vol.22 , pp. 103-112
    • Hara, Y.1    Nakajima, M.2    Miyamoto, K.3    Yokoi, T.4
  • 27
    • 0032925868 scopus 로고    scopus 로고
    • Persistently high plasma morphine-6-glucuronide levels despite decreased hourly patient-controlled analgesia morphine use after single-dose diclofenac: Potential for opioid-related toxicity
    • Tighe, K. E., Webb, A. M. and Hobbs, G. J.: Persistently high plasma morphine-6-glucuronide levels despite decreased hourly patient-controlled analgesia morphine use after single-dose diclofenac: potential for opioid-related toxicity. Anesth. Analg., 88: 1137-1142 (1999).
    • (1999) Anesth. Analg , vol.88 , pp. 1137-1142
    • Tighe, K.E.1    Webb, A.M.2    Hobbs, G.J.3
  • 28
    • 0025049149 scopus 로고
    • Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man
    • Ventafridda, V., Bianchi, M., Ripamonti, C., Sacerdote, P., De Conno, F., Zecca, E. and Panerai, A. E.: Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man. Pain, 43: 155-162 (1990).
    • (1990) Pain , vol.43 , pp. 155-162
    • Ventafridda, V.1    Bianchi, M.2    Ripamonti, C.3    Sacerdote, P.4    de Conno, F.5    Zecca, E.6    Panerai, A.E.7
  • 29
    • 0036118877 scopus 로고    scopus 로고
    • Abatement of morphine-induced slowing in gastrointestinal transit by Dai-kenchu-to, a traditional Japanese herbal medicine
    • Nakamura, T., Sakai, A., Isogami, I., Noda, K., Ueno, K. and Yano, S.: Abatement of morphine-induced slowing in gastrointestinal transit by Dai-kenchu-to, a traditional Japanese herbal medicine. Jpn. J. Pharmacol., 88: 217-221 (2002).
    • (2002) Jpn. J. Pharmacol , vol.88 , pp. 217-221
    • Nakamura, T.1    Sakai, A.2    Isogami, I.3    Noda, K.4    Ueno, K.5    Yano, S.6
  • 31
    • 0027931806 scopus 로고
    • Effect of fluconazole on zidovudine pharmacokinetics in patients infected with human immunodeficiency virus
    • Sahai, J., Gallicano, K., Pakuts, A. and Cameron, D. W.: Effect of fluconazole on zidovudine pharmacokinetics in patients infected with human immunodeficiency virus. J. Infect. Dis., 169: 1103-1107 (1994).
    • (1994) J. Infect. Dis , vol.169 , pp. 1103-1107
    • Sahai, J.1    Gallicano, K.2    Pakuts, A.3    Cameron, D.W.4
  • 32
    • 0031808472 scopus 로고    scopus 로고
    • Glucuronidation of 3′-azido-3′-deoxythymidine (zidovudine) by human liver microsomes: Relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid
    • Trapnell, C. B., Klecker, R. W., Jamis-Dow, C. and Collins, J. M.: Glucuronidation of 3′-azido-3′-deoxythymidine (zidovudine) by human liver microsomes: relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid. Antimicrob. Agents Chemother., 42: 1592-1596 (1998).
    • (1998) Antimicrob. Agents Chemother , vol.42 , pp. 1592-1596
    • Trapnell, C.B.1    Klecker, R.W.2    Jamis-Dow, C.3    Collins, J.M.4
  • 33
    • 33344478229 scopus 로고    scopus 로고
    • Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: The effect of fluconazole on zidovudine glucuronidation
    • Uchaipichat, V., Winner, L. K., Mackenzie, P. I., Elliot, D. J., Williams, J. A. and Miners, J. O.: Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation. Br. J. Clin. Pharmacol., 61: 427-439 (2006).
    • (2006) Br. J. Clin. Pharmacol , vol.61 , pp. 427-439
    • Uchaipichat, V.1    Winner, L.K.2    Mackenzie, P.I.3    Elliot, D.J.4    Williams, J.A.5    Miners, J.O.6
  • 34
    • 33947398317 scopus 로고    scopus 로고
    • Binding of inhibitory fatty acids is responsible for the enhancement of UDP-glucuronosyltransferase 2B7 activity by albumin: Implications for in vitro-in vivo extrapolation
    • Rowland, A., Gaganis, P., Elliot, D. J., Mackenzie, P. I., Knights, K. M. and Miners, J. O.: Binding of inhibitory fatty acids is responsible for the enhancement of UDP-glucuronosyltransferase 2B7 activity by albumin: implications for in vitro-in vivo extrapolation. J. Pharmacol. Exp. Ther., 321: 137-147 (2007).
    • (2007) J. Pharmacol. Exp. Ther , vol.321 , pp. 137-147
    • Rowland, A.1    Gaganis, P.2    Elliot, D.J.3    Mackenzie, P.I.4    Knights, K.M.5    Miners, J.O.6
  • 35
    • 85004809753 scopus 로고
    • Inhibition of UDP-glucuronosyltransferase by aglycons of natural glucuronides in kampo medicines using SN-38 as a substrate
    • Yokoi, T., Narita, M., Nagai, E., Hagiwara, H., Aburada, M. and Kamataki, T.: Inhibition of UDP-glucuronosyltransferase by aglycons of natural glucuronides in kampo medicines using SN-38 as a substrate. Jpn. J. Cancer Res., 86: 985-989 (1995).
    • (1995) Jpn. J. Cancer Res , vol.86 , pp. 985-989
    • Yokoi, T.1    Narita, M.2    Nagai, E.3    Hagiwara, H.4    Aburada, M.5    Kamataki, T.6
  • 36
    • 0036843498 scopus 로고    scopus 로고
    • Involvement of multiple UDP-glucuronosyltransferase 1A isoforms in glucuronidation of 5-(4′-hydroxyphenyl)-5-pheny lhydantoin in human liver microsomes
    • Nakajima, M., Sakata, N., Ohashi, N., Kume, T. and Yokoi, T.: Involvement of multiple UDP-glucuronosyltransferase 1A isoforms in glucuronidation of 5-(4′-hydroxyphenyl)-5-pheny lhydantoin in human liver microsomes. Drug Metab. Dispos., 30: 1250-1256 (2002).
    • (2002) Drug Metab. Dispos , vol.30 , pp. 1250-1256
    • Nakajima, M.1    Sakata, N.2    Ohashi, N.3    Kume, T.4    Yokoi, T.5
  • 37
    • 2442649042 scopus 로고    scopus 로고
    • Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases
    • Sridar, C., Goosen, T. C., Kent, U. M., Williams, J. A. and Hollenberg, P. F.: Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases. Drug Metab. Dispos., 32: 587-594 (2004).
    • (2004) Drug Metab. Dispos , vol.32 , pp. 587-594
    • Sridar, C.1    Goosen, T.C.2    Kent, U.M.3    Williams, J.A.4    Hollenberg, P.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.