Long-lived states to sustain hyperpolarized magnetization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 44, 2009, Pages 18469-18473

  Vasos, P R ^a   Comment, A ^a   Sarkar, R ^a   Ahuja, P ^a   Jannin, S ^a   Ansermet, J P ^a   Konter, J A ^b   Hautle, P ^b   Van Den Brandt, B ^b   Bodenhausen, G ^a,c  

^a EPFL   (Switzerland)

^b PAUL SCHERRER INSTITUTE   (Switzerland)

^c ECOLE NORMALE SUPÉRIEURE   (France)

Author keywords

Dissolution process; Dynamic nuclear polarization; Magnetic resonance imaging; Metabolic pathways; Nuclear magnetic resonance

Indexed keywords

CARBON 13; DIPEPTIDE; GLYCINE; PEPTIDE; PROTON;

ARTICLE; CONTROLLED STUDY; DISSOLUTION; HYPERPOLARIZATION; LIFESPAN; MAGNET; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RADIOFREQUENCY RADIATION; RELAXATION TIME;

DIPEPTIDES; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETICS; PROTONS; TIME FACTORS;

EID: 73249139983     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908123106     Document Type: Article

References (40)

1. Abragam A, Goldman M (1978) Principles of dynamic nuclear polarization. Rep Prog Phys 41:395-467.
2. Day SE, et al. (2007) Detecting tumor response to treatment using hyperpolarized C-13 magnetic resonance imaging and spectroscopy. Nat Med 13:1382-1387.
3. Golman K, Ardenkjaer-Larsen JH, Petersson JS, Mansson S, Leunbach I (2003) Molecular imaging with endogenous substances. Proc Natl Acad Sci USA 100:10435-10439.
4. Becerra LR, Gerfen GJ, Temkin RJ, Singel DJ, Griffin RG (1993) Dynamic nuclearpolarization with a cyclotron-resonance maser at 5-T. Phys Rev Lett 71:3561-3564.
5. Prandolini MJ, Denysenkov VP, Gafurov M, Endeward B, Prisner TF (2009) High-field dynamic nuclear polarization in aqueous solutions. J Am Chem Soc 131:6090-6092.
6. Overhauser AW (1953) Polarization of nuclei in metals. Phys Rev 91:476.
7. Carver TR, Slichter CP (1956) Experimental verification of the Overhauser nuclear polarization effect. Phys Rev 102:975-980.
8. Ardenkjaer-Larsen JH, et al. (2003) Increase in signal-to-noise ratio of 10,000 times in liquid-state NMR. Proc Natl Acad Sci USA 100:10158-10163.
9. Carravetta M, Johannessen OG, Levitt MH (2004) Beyond the T1 limit: Singlet nuclear spin states in low magnetic fields. Phys Rev Lett 92:153003.
10. Ahuja P, Sarkar R, Vasos PR, Bodenhausen G (2007) Molecular properties determined from the relaxation of long-lived spin states. J Chem Phys 127:134112.
11. Golman K, in't Zandt R, ThaningM(2006) Real-timemetabolic imaging. Proc Natl Acad Sci USA 103:11270-11275.
12. Merritt ME, et al. (2007) Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci USA 104:19773-19777.
13. Callaghan PT, Coy A, MacGowan D, Packer KJ, Zelaya FO (1991) Diffraction-like effects in NMR diffusion studies of fluids in porous solids. Nature 351:467-469.
14. Golman K, Zandt RI, Lerche M, Pehrson R, Ardenkjaer-Larsen JH (2006) Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res 66:10855-10860.
15. Blamire AM (2008) The technology of MRI-the next 10 years? Br J Radiol 81:601-617.
16. Gallagher FA, et al. (2008) Magnetic resonance imaging of pH in vivo using hyperpolarized C-13-labelled bicarbonate. Nature 453:940-U973.
17. Frydman L, Blazina D (2007) Ultrafast two-dimensional nuclear magnetic resonance spectroscopy of hyperpolarized solutions. Nat Phys 3:415-419.
18. Mishkovsky M, Frydman L (2008) Progress in hyperpolarized ultrafast 2D NMR spectroscopy. ChemPhysChem 9:2340-2348.
19. Pelupessy P (2003) Adiabatic single scan two-dimensional NMR spectroscopy. J Am Chem Soc 125:12345-12350.
20. Pelupessy P, Rennella E, Bodenhausen G (2009) High-resolution NMR with unknown spatiotemporal variations of magnetic fields. Science 324:1693-1697.
21. Carravetta M, Levitt MH (2004) Long-lived nuclear spin states in high-field solution NMR. J Am Chem Soc 126:6228-6229.
22. Sarkar R, Vasos PR, Bodenhausen G (2007) Singlet-state Exchange NMR spectroscopy for the study of very slow dynamic processes. J Am Chem Soc 129:328-334.
23. Canet D, Bouguet-Bonnet S, Aroulanda C, Reineri F (2007) About long-lived nuclear spin states involved in para-hydrogenated molecules. J Am Chem Soc 129:1445-1449.
24. Vinogradov E, Grant AK (2008) Hyperpolarized long-lived states in solution NMR: Three-spin case study in low field. J Magn Reson 194:46-57.
25. Warren WS, Jenista E, Branca RT, Chen X (2009) Increasing hyperpolarized spin lifetimes through true singlet eigenstates. Science 323:1711-1714.
26. Edwards CMB, Cohen MA, Bloom SR (1999) Peptides as drugs. Q J Med 92:1-4.
27. Wilson DM, et al. (2009) Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride. Proc Natl Acad Sci USA 106:5503-5507.
28. Pileio G, Carravetta M, Hughes E, Levitt MH (2008) The long-lived nuclear singlet state of N-15-nitrous oxide in solution. J Am Chem Soc 130:12582-12583.
29. Comment A, et al. (2007) Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner. Concepts Magn Reson B 31B:255-269.
30. Morris GA, Freeman R (1979) Enhancement of nuclear magnetic-resonance signals by polarization transfer. J Am Chem Soc 101:760-762.
31. Ahuja P, Sarkar R, Vasos PR, Bodenhausen G (2009) Long lived states in multiple-spin systems. ChemPhysChem,
32. Sarkar R, Ahuja P, Moskau D, Vasos PR, Bodenhausen G (2007) Extending the scope singlet-state spectroscopy. ChemPhysChem 8:2652-2656.
33. Sarkar R, Ahuja P, Vasos PR, Bodenhausen G (2008) Measurement of slow diffusion coefficients of molecules with arbitrary scalar couplings via long-lived spin states. ChemPhysChem 9:2414-2419.
34. Sarkar R, Moskau D, Ferrage F, Vasos PR, Bodenhausen G (2008) Single or triple gradients? J Magn Reson 193:110-118.
35. Cavadini S, Vasos PR (2008) Singlet states open the way to longer time-scales in the measurement of diffusion by NMR spectroscopy. Concepts Magn Reson 32A:68-78.
36. Pileio G, Concistré M, Carravetta M, Levitt MH (2006) Long-lived nuclear spin states in the solution NMR of four-spin systems. J Magn Reson 182:353-357.
37. Vinogradov E, Grant AK (2007) Long-lived states in solution NMR: Selection rules for intramolecular dipolar relaxation in low magnetic fields. J Magn Reson 188:176-182.
38. Ahuja P, Sarkar R, Vasos PR, Bodenhausen G (2009) Diffusion coefficients of biomolecules using long-lived spin states. J Am Chem Soc 131:7498-7499.
39. Merritt ME, et al. (2007) Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance. J Am Chem Soc 129:12942-12943.
40. Shaka AJ, Keeler J, Frenkiel T, Freeman R (1983) An improved sequence for broad-band decoupling-WALTZ-16. J Magn Reson 52:335-338.