Soluble HLA-I-mediated secretion of TGF-β1 by human NK cells and consequent down-regulation of anti-tumor cytolytic activity

European Journal of Immunology

Volumn 39, Issue 12, 2009, Pages 3459-3468

  Ghio, Massimo ^a   Contini, Paola ^a   Negrini, Simone ^a   Boero, Silvia ^b   Musso, Alessandra ^b   Poggi, Alessandro ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Cytolysis; NK cells; Soluble HLA I; TGF 1

Indexed keywords

CD69 ANTIGEN; CD8 ANTIGEN; CELL RECEPTOR; CYTOKINE; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; INTERLEUKIN 2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL1; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL2; MESSENGER RNA; MONOCLONAL ANTIBODY; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 2; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN 2B4; PROTEIN DNAM1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLELE; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CLONE; CELL CYCLE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; FLOW CYTOMETRY; GENE AMPLIFICATION; HUMAN; HUMAN CELL; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA ISOLATION; TUMOR CELL DESTRUCTION; UPREGULATION;

ANIMALS; ANTIGENS, CD8; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOTOXICITY, IMMUNOLOGIC; DOWN-REGULATION; FLOW CYTOMETRY; HLA ANTIGENS; HLA-C ANTIGENS; HUMANS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; PROTEIN BINDING; RECEPTORS, KIR; RECEPTORS, KIR2DL1; RECEPTORS, KIR2DL2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SOLUBILITY; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 73249139917     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939728     Document Type: Article

References (25)

1. Parham, P., Clayberger, C., Zorn, S. L., Ludwig, D. S., Schoolnik, G. K. and Krensky, AM., Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the alpha 2 domain of HLA-A2. Nature 1987, 325: 625-628.
2. Dal Porto, J., Johansen, T. E., Catipovic, B., Parfiit, D. J., Tuveson, D., Gether, U., Kozlowski, S. et al., A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations. Proc Natl Acad Sci U S A 1993, 90: 6671-6675.
3. Puppo, F., Brenci, S., Lanza, L., Bosco, O., Imro, M. A., Scudeletti, M., Indiveri, F. and Ferrone, S., Increased level of serum HLA class I antigens in HIV infection. Correlation with disease progression. Hum Immunol 1994, 40: 259-266.
4. Mathew, J. M., Shenoy, S., Phelan, D., Lowell, J., Howard, T. and Mohanakumar, T., Biochemical and immunological evaluation of donor specific soluble HLA in the circulation of liver transplan recipients. Transplantation 1996, 62: 217-223.
5. Tsuchiya, N., Shiota, M., Yamaguchi, A. and Ito, K., Elevated serum level of soluble HLA class I antigens in patients with systemic lupus erythematosus. Arthritis and Rheumatism 1996, 39: 792-796.
6. Carbone, E., Terrazzano, G., Colonna, M., Tosto, L., Piccolella, E., Franksson, L., Palazzolo, G. et al., Natural killer clones recognize specific soluble HLA class I molecules. Eur J Immunol 1996, 26: 683-689.
7. Zavazava, N. and Kronke, M., Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nat Med 1996, 2: 1005-1010.
8. Nocito, M., Montalban, C., Gonzalez-Porque, P. and Villar, L. M., Increased soluble serum HLA class I antigens in patients with lymphoma. Hum Immunol 1997, 58: 106-111.
9. Zavazava, N., Soluble HLA class I molecules: biological significance and clinical implications. Mol Med Today 1998, 3: 116-121.
10. Westhoff, U., Fox, C. and Otto, F. J., Soluble HLA class I antigens in plasma of patients with malignant melanoma. Anticancer Res 1998, 18: 3789-3792.
11. + lymphocytes in acute myeloid leukemia patients: involvement of soluble HLA-I and Fas ligand. Leukemia 2007, 21: 253-260.
12. Moretta, A., Bottino, C., Vitale, M., Pende, D., Biassoni, R., Mingari, M. C. and Moretta, L., Receptors for HLA class-I molecules in human natural killer cells. Annu Rev Immunol 1996, 14: 619-648.
13. Lanier, L. L., NK cell receptors. Annu Rev Immunol 1998, 16: 359-393.
14. Long, E. O., Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 1999, 17: 875-904.
15. Spaggiari, G. M., Contini, P., Carosio, R., Arvigo, M., Ghio, M., Oddone, D., Dondero, A. et al., Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily. Blood 2002, 99: 1706-1714.
16. Spaggiari, G. M., Contini, P., Dondero, A., Carosio, R., Puppo, F., Indiveri, F., Zocchi, M. R. and Poggi, A., Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-stimulatory HLA class I receptors through FasL-Fas interaction. Blood 2002, 100: 4098-4107.
17. Blobe, G. C., Schiemann, W. P. and Lodish, H. F., Role of transforming growth factor beta in human disease. N Engl J Med 2000, 342: 1350-1358.
18. Chen, W., Frank, M. E., Jin, W. and Wahl, S. M., TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 2001, 14: 715-725.
19. Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A. K. and Flavell, R. A., Transforming growth factor-β regulation of immune responses. Annu. Rev. Immunol. 2006, 24: 99-146.
20. Biswas, S., Criswell, T. L., Wang, S. E., Arteaga, C. L., Inhibition of transforming growth factor-β signaling in human cancer: targeting a tumor suppressor network as a therapeutic strategy. Clin. Cancer Res 2006, 12: 4142-4146.
21. Castriconi, R., Cantoni, C., Della Chiesa, M., Vitale, M., Marcenaro, E., Conte, R., Biassoni, R., Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: consequences for NK cell-mediated killing of dendritic cells. Proc. Natl. Acad. Sci. USA 2003, 100: 4120-4125.
22. Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M. C., Biassoni, R. and Moretta, L., Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol 2001, 19: 197.
23. Poggi, A., Negrini, S., Zocchi, M. R., Massaro, A. M., Gargiulo, L., Notaro, R. and Luzzatto, L., Patients with Paroxysmal Nocturnal Hemoglobinuria have a high frequency of peripheral blood T cells expressing activating isoforms of inhibitory Superfamily Receptors. Blood 2005, 106: 2399-2408.
24. Tsang, M. L., Zhou, L., Zheng, B. L., Wenker, J., Fransen, G., Humphrey, J., Smith, J. M. et al., Characterization of recombinant soluble human transforming growth factor-beta receptor type II (rhTGF-beta sRII). Cytokine 1995, 7: 389-397.
25. Gabert, J., Beillard, F., H.van der Velden, V., Bi, W., Grimwade, D., Pallisgaard, N., Barbany, G. et al., Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program. Leukemia 2003 17: 2318-2357.