Soluble HLA class I molecules: Biological significance and clinical implications

Molecular Medicine Today

Volumn 4, Issue 3, 1998, Pages 116-121

  Zavazava, Nicholaus ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1;

APOPTOSIS; CELL ACTIVITY; CEREBROSPINAL FLUID; GENETIC HETEROGENEITY; HLA SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; PHENOTYPE; RECEPTOR UPREGULATION; REVIEW;

ANIMALS; APOPTOSIS; GRAFT SURVIVAL; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; SOLUBILITY; T-LYMPHOCYTES; TRANSPLANTATION IMMUNOLOGY;

EID: 0031980370     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(97)01185-4     Document Type: Review

References (43)

1. Bjorkmann P.et al. Structure of the human class I histocompatibility antigen HLAβ-A2. Nature. 329:1987;506-512.
2. Charlton R.K., Zmijewski C.M. Soluble HL-A7 antigen: localization in the β-lipoprotein fraction of human serum. Science. 170:1970;636-637.
3. van Rood J., van Leeuwen A., van Santen M. Anti HL-A2 inhibitor in normal human serum. Nature. 226:1970;366-367.
4. Allison J.et al. Biologic and chemical characterization of HLA antigens in human serum. J. Immunol. 118:1977;1004-1009.
5. k antigens are shed as supramolecular particles in association with membrane lipids. J. Immunol. 127:1981;482-486.
6. Wilson B., Indiveri F., Pellegrino M., Ferrone S. Production and characterization of DR xenoantisera: use for detection of serum DR antigens. J. Immunol. 122:1979;1967-1971.
7. Pouletty P.et al. Summary report from the first international workshop on soluble HLA antigens. Paris, August 1992. Tissue Antigens. 42:1993;45-54.
8. Grumet F. Report of the Second International Soluble HLA (sHLA) Workshop. Hum. Immunol. 40:1994;153-165.
9. Emerson S., Murphy D., Cone R. Selective turnover and shedding of H-2K and H-2D antigens is controlled by the major histocompatibility complex. J. Exp. Med. 152:1980;783-795.
10. Emerson S., Cone R. Absorption of shed I-Ak and H-2Kk antigens by lymphoid cells. Transplantation. 33:1982;36-40.
11. Zavazava N., Böttcher H., Mueller-Ruchholtz W.M. Soluble MHC class I antigens (sHLA) and anti-HLA antibodies in heart and kidney allograft recipients. Tissue Antigens. 42:1993;20-26.
12. DeVito-Haynes L.et al. Monitoring of kidney and simultaneous pancreas-kidney transplantation rejection by release of donor-specific soluble HLA class I. Hum. Immunol. 40:1994;191-201.
13. Puppo F., Scudeletti M., Indiveri F., Ferrone S. Serum HLA class I antigens: markers and modulators of an immune reponse? Immunol. Today. 16:1995;124-127.
14. Mathew J.M.et al. Biochemical and immunological evaluation of donor specific soluble HLA in the circulation of liver transplant recipients. Transplantation. 62:1996;217-223.
15. Zavazava N.et al. Expression of MHC class I and class II molecules by cadaver retinal pigment epithelium cells: optimization of post-mortem HLA typing. Clin. Exp. Immunol. 84:1991;163-166.
16. Aulitzky W.et al. Enhanced serum levels of soluble HLA class I molecules are induced by treatment with recombinant interferon-gamma (IFN-γ). Clin. Exp. Immunol. 86:1994;236-239.
17. Shimura T.et al. Quatitation of serum-soluble HLA class I antigens in patients with gastric cancer. Hum. Immunol. 40:1994;183-186.
18. Calne R., Davies H. Organ graft tolerance: the liver effect. Lancet. 343:1994;67-68.
19. Sriwatanawongsa V., Davies H., Calne R. The essential roles of parenchymal tissues and passenger leukocytes in the tolerance induced by liver grafting in rats. Nat. Med. 1:1995;428-432.
20. Starzl T.E.et al. The lost chord: microchimerism and allograft survival. Immunol. Today. 17:1996;577-584.
21. Elliott T., Eisen H. Allorecognition of purified major histocompatibility complex glycoproteins by cytotoxic T lympocytes. Proc. Natl. Acad. Sci. U. S. A. 85:1988;2728-2732.
22. Kane K., Sherman L., Mescher M. Molecular interactions required for triggering alloantigen-specific cytolytic T lympocytes. J. Immunol. 142:1989;4160-4253.
23. Abastado J.et al. Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness. J. Exp. Med. 182:1995;439-447.
24. Hausmann R., Zavazava N., Steinmann J., Mueller-Ruchholtz W.M. Interaction of papain-digested HLA class I molecules with human alloreactive cytotoxic T lymphocytes (CTL). Clin. Exp. Immunol. 91:1993;183-188.
25. Carbone E.et al. Natural killer clones recognize specific soluble HLA class I molecules. Eur. J. Immunol. 26:1996;683-689.
26. Schneck J., Maloy W., Coligan J., Margulies D. Inhibition of an allospecific T cell hybridoma by soluble class I proteins and peptides: estimation of the affinity of a T cell receptor for MHC. Cell. 56:1989;47-55.
27. Porto J.et al. A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations. Proc. Natl. Acad. Sci. U. S. A. 90:1993;6671-6675.
28. Zavazava N., Krönke M. Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nat. Med. 2:1996;1005-1010.
29. Kroemer G.et al. The biochemistry of programmed cell death. FASEB J. 9:1995;1277-1287.
30. Podack E. Functional significance of two cytolytic pathways of cytotoxic T lymphocytes. J. Leukocyte Biol. 57:1995;548-552.
31. Gill R.G., Coulombe M., Lafferty K.J. Pancreatic islet allograft immunity and tolerance: the two-signal hypothesis revisited. Immunol. Rev. 149:1996;75-96.
32. Arimilli S., Mumm J.B., Nag B. Antigen-specific apoptosis in immortalized T cells by soluble MHC class II-peptide complexes. Immunol. Cell Biol. 74:1996;96-104.
33. Nag B., Mukku P.V., Astafieva I. Functionally active recombinant alpha and beta chain-peptide complexes of human major histocompatibility class II molecules. J. Biol. Chem. 271:1996;10413-10418.
34. Rhode P.R.et al. Single-chain MHC class II molecules induce T cell activation and apoptosis. J. Immunol. 157:1996;4885-4891.
35. Arnold B.et al. Transgenic mice expressing a soluble foreign H-2 class I antigen are tolerant to allogeneic fragments presented by self class I but not to the whole membrane-bound alloantigen. Proc. Natl. Acad. Sci. U. S. A. 87:1990;1762-1766.
36. d in animals transgenic for its soluble analog. Hum. Immunol. 52:1997;82-94.
37. Grumet F.et al. Soluble form of an HLA-B7 class I antigen specifically suppresses humoral alloimmunization. Hum. Immunol. 40:1994;228-234.
38. Knechtle S.J., Zhai Y., Fechner J. Gene therapy in transplantation. Transp. Immunol. 4:1996;257-264.
39. Knechtle S.J.et al. Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex. Transplantation. 57:1994;990-996.
40. Wang M.et al. Induction of specific allograft immunity by soluble class I MHC heavy chain protein produced in a baculovirus expression system. Transplantation. 61:1996;448-457.
41. a molecules. Transplantation. 62:1996;1002-1010.
42. Saririan K.et al. Serum HLA class I levels in elderly humans: utilization in following the response to influenza vaccine. Hum. Immunol. 40:1994;202-209.
43. Geissler E.K., Korzun W.J., Graeb C. Secreted donor-MHC class I antigen prolongs liver allograft survival and inhibits recipient anti-donor cytotoxic T lymphocyte responses. Transplantation. 64:1997;782-786.