Casein-derived tripeptide, Val-Pro-Pro (VPP), modulates monocyte adhesion to vascular endothelium

Journal of Atherosclerosis and Thrombosis

Volumn 16, Issue 5, 2009, Pages 594-603

  Aihara, Kotaro ^a   Ishii, Hideto ^b   Yoshida, Masayuki ^b  

^a CALPIS Co Ltd   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Adhesion; Atherosclerosis; Food derived tripeptide; Monocyte; PMA

Indexed keywords

ANTIHYPERTENSIVE AGENT; ISOLEUCYLPROLYLPROLINE; PHORBOL 13 ACETATE 12 MYRISTATE; TRIPEPTIDE; UNCLASSIFIED DRUG; VALYLPROLYLPROLINE;

ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROGENESIS; CELL ADHESION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERTENSION; MONOCYTE; PROTEIN PHOSPHORYLATION; UPREGULATION; VASCULAR ENDOTHELIUM;

EID: 73249119117     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.729     Document Type: Article

References (41)

1. Appel LJ, Sacks FM, Carey VJ, Obarzanek E, Swain JF, Miller ER III, Conlin PR, Erlinger TP, Rosner BA, Laranjo NM, Charleston J, McCarron P, Bishop LM, and for the OmniHeart Collaborative Research Group: Effects of Protein, Monounsaturated Fat, and Carbohydrate Intake on Blood Pressure and Serum Lipids: Results of the Omni-Heart Randomized Trial. JAMA, 2005; 294: 2455-2464
2. Appel LJ: The effects of protein intake on blood pressure and cardiovascular disease. Curr Opin Lipidol, 2003; 14: 55-59
3. Hartmann R, Meisel H: Food-derived peptides with biological activity: from research to food applications. Curr Opin Biotechnol, 2007; 18: 163-169
4. Yamamoto N, Ejiri M, Mizuno S: Biogenic peptides and their potential use. Curr Pharm Des, 2003; 9: 1345-1355
5. Murray BA, FitzGerald RJ: Angiotensin converting enzyme inhibitory peptides derived from food proteins: biochemistry, bioactivity and production. Curr Pharm Des, 2007; 13: 773-791
6. Heeneman S, Sluimer JC, Daemen MJ: Angiotensin-Converting Enzyme and Vascular Remodeling. Circ Res, 2007; 101: 441-454
7. Kowala MC, Grove RI, Aberg G: Inhibitors of angiotensin converting enzyme decrease early atherosclerosis in hyperlipidemic hamsters. Fosinopril reduces plasma cholesterol and captopril inhibits macrophage-foam cell accumulation independently of blood pressure and plasma lipids. Atherosclerosis, 1994; 108: 61-72
8. Song K, Shiota N, Takai S, Takashima H, Iwasaki H, Kim S, Miyazaki M: Induction of angiotensin converting enzyme and angiotensin II receptors in the atherosclerotic aorta of high-cholesterol fed Cynomolgus monkeys. Atherosclerosis, 1998; 138: 171-182
9. Hayek T, Attias J, Coleman R, Brodsky S, Smith J, Breslow JL, Keidar S: The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin III receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E deficient mice. Cardiovasc Res, 1999; 44: 579-587
10. Nakamura Y, Yamamoto N, Sakai K, Okubo A, Yamazaki S, Takano T: Purification and Characterization of Angiotensin I-Converting Enzyme Inhibitors from Sour Milk. J Dairy Sci, 1995; 78: 777-783
11. Mizuno S, Nishimura S, Matsuura K, Gotou T, Yamamoto N: Release of Short and Proline-Rich Antihypertensive Peptides from Casein Hydrolysate with an Aspergillus oryzae Protease. J Dairy Sci, 2004; 87: 3183-3188
12. Hata Y, Yamamoto M, Ohni M, Nakajima K, Nakamura Y, Takano T: A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr, 1996; 64: 767-771
13. Seppo L, Jauhiainen T, Poussa T, Korpela R: A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr, 2003; 77: 326-330
14. Hirota T, Ohki K, Kawagishi R, Kajimoto Y, Mizuno S, Nakamura Y, Kitakaze M: Casein hydrolysate containing the antihypertensive tripeptides Val-Pro-Pro and Ile-Pro-Pro improves vascular endothelial function independent of blood pressure-lowering effects: contribution of the inhibitory action of angiotensin-converting enzyme. Hypertens Res, 2007; 30: 489-496
15. Butcher EC: Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell, 1991; 67: 1033-1036
16. Ross R: Atherosclerosis - An Inflammatory Disease. N Engl J Med, 1999; 340: 115-126
17. Fan J, Watanabe T: Inflammatory reactions in the pathogenesis of atherosclerosis. J Atheroscler Thromb, 2003; 10: 63-71
18. Yoshida M, Sawada T, Ishii H, Gerszten RE, Rosenzweig A, Gimbrone MA, Jr, Yasukochi Y, Numano F: HMG-CoA Reductase Inhibitor Modulates Monocyte-Endothelial Cell Interaction Under Physiological Flow Conditions In Vitro : Involvement of Rho GTPase-Dependent Mechanism. Arterioscler Thromb Vasc Biol, 2001; 21: 1165-1171
19. Mori D, Ishii H, Kojima C, Nitta N, Nakajima K, Yoshida M: Cilostazol inhibits monocytic cell adhesion to vascular endothelium via upregulation of cAMP. J Atheroscler Thromb, 2007; 14: 213-218
20. Kawakami A, Tanaka A, Nakajima K, Shimokado K, Yoshida M: Atorvastatin Attenuates Remnant Lipoprotein-Induced Monocyte Adhesion to Vascular Endothelium Under Flow Conditions. Circ Res, 2002; 91: 263-271
21. Kojima C, Kawakami A, Takei T, Nitta K, Yoshida M: Angiotensin-Converting Enzyme Inhibitor Attenuates Monocyte Adhesion to Vascular Endothelium through Modulation of Intracellular Zinc. J Pharmacol Exp Ther, 2007; 323: 855-860
22. Yu T, Morita I, Shimokado K, Iwai T, Yoshida M: Amlodipine Modulates THP-1 Cell Adhesion to Vascular Endothelium via Inhibition of Protein Kinase C Signal Transduction. Hypertension, 2003; 42: 329-334
23. Takahashi K, Shimokado K, Yoshida M: SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition. Eur J Pharmacol, 2006; 552: 162-169
24. Ashida N, Arai H, Yamasaki M, Kita T: Distinct Signaling Pathways for MCP-1-dependent Integrin Activation and Chemotaxis. J Biol Chem, 2001; 276: 16555-16560
25. Metzger R, Bohle RM, Chumachenko P, Danilov SM, Franke FE: CD143 in the development of atherosclerosis. Atherosclerosis, 2000; 150: 21-31
26. Fukuhara M, Geary RL, Diz DI, Gallagher PE, Wilson JA, Glazier SS, Dean RH, Ferrario CM: Angiotensin-Converting Enzyme Expression in Human Carotid Artery Atherosclerosis. Hypertension, 2000; 35: 353-359
27. Villard E, Alonso A, Agrapart M, Challah M, Soubrier F: Induction of Angiotensin I-converting Enzyme Transcription by a Protein Kinase C-dependent Mechanism in Human Endothelial Cells. J Biol Chem, 1998; 273: 25191-25197
28. Chattopadhyay S, Santhamma KR, Sengupta S, McCue B, Kinter M, Sen GC, Sen I: Calmodulin Binds to the Cytoplasmic Domain of Angiotensin-converting Enzyme and Regulates Its Phosphorylation and Cleavage Secretion. J Biol Chem, 2005; 280: 33847-33855
29. Carman CV, Springer TA: Integrin avidity regulation: are changes in affinity and conformation underemphasized ? Curr Opin Cell Biol, 2003; 15: 547-556
30. Laudanna C, Kim JY, Constantin E, Butcher EC: Rapid leukocyte integrin activation by chemokines. Immunol Rev, 2002; 186: 37-46
31. 1 Integrin Chain. J Biol Chem, 1998; 273: 7981-7987
32. 2 Subunit Reveals Regions that Become Exposed Upon Receptor Activation. J Immunol, 2001; 166: 5629-5637
33. Erdmann K, Cheung BWY, Schröder H: The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. J Nutr Biochem, 2008; 19: 643-654
34. Tsao PS, Niebauer J, Buitrago R, Lin PS, Wang BY, Cooke JP, Chen YD, Reaven GM: Interaction of Diabetes and Hypertension on Determinants of Endothelial Adhesiveness. Arterioscler Thromb Vasc Biol, 1998; 18: 947-953
35. Masuda O, Nakamura Y, Takano T: Antihypertensive Peptides Are Present in Aorta after Oral Administration of Sour Milk Containing These Peptides to Spontaneously Hypertensive Rats. J Nutr, 1996; 126: 3063-3068
36. Nakamura Y, Masuda O, Takano T: Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats. Biosci Biotechnol Biochem, 1996; 60: 488-489
37. Foltz M, Meynen EE, Bianco V, van Platerink C, Koning TM, Kloek J: Angiotensin Converting Enzyme Inhibitory Peptides from a Lactotripeptide- Enriched Milk Beverage Are Absorbed Intact into the Circulation. J Nutr, 2007; 137: 953-958
38. Matsui T, Tamaya K, Seki E, Osajima K, Matsumoto K, Kawasaki T: Val-Tyr As A Natural Antihypertensive Dipeptide Can Be Absorbed Into The Human Circulatory Blood System. Clin Exp Pharmacol Physiol, 2002; 29: 204-208
39. Matsui T, Tamaya K, Seki E, Osajima K, Matsumo K, Kawasaki T: Absorption of Val-Tyr with in vitro angiotensin I-converting enzyme inhibitory activity into the circulating blood system of mild hypertensive subjects. Biol Pharm Bull, 2002; 25: 1228-1230
40. 2+ channel inhibition in cultured vascular smooth muscle cells. Hypertens Res, 2005; 28: 545-552
41. Hagita S, Osaka M, Shimokado K, Yoshida M: Oxidative Stress in Mononuclear Cells Plays a Dominant Role in Their Adhesion to Mouse Femoral Artery After Injury. Hypertension, 2008; 51: 797-802