Angiotensin-converting enzyme inhibitor attenuates monocyte adhesion to vascular endothelium through modulation of intracellular zinc

Journal of Pharmacology and Experimental Therapeutics

Volumn 323, Issue 3, 2007, Pages 855-860

  Kojima, Chiari ^a,b   Kawakami, Akio ^a   Takei, Takashi ^b   Nitta, Kosaku ^b   Yoshida, Masayuki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; BETA2 INTEGRIN; CHELATING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMIDAPRIL; IMIDAPRILAT; MONOCYTE CHEMOTACTIC PROTEIN 1; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C INHIBITOR; PYRITHIONE ZINC; ZINC;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; MONOCYTE; PRIORITY JOURNAL; UPREGULATION; VASCULAR ENDOTHELIUM;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CELL ADHESION; CELL LINE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; HUMANS; IMIDAZOLIDINES; IMMUNOBLOTTING; MONOCYTES; PEPTIDYL-DIPEPTIDASE A;

EID: 36348986786     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.127944     Document Type: Article

References (35)

1. AbdAlla HL, Andreas Langer, and Yasser el Faramawy aUQ, and Heinrich-Pette-Institut (2004) Factor XIIIA transglutaminase crosslinks at1 receptor dimers of monocytes at the onset of atherosclerosis. Cell 119:343-354.
2. Beyersmann D and Haase H (2001) Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals 14:331-341.
3. Braunwald E, Pfeffer MA, Domanski M, Fowler S, Rice M, Rosenberg Y, Dunlap M, Flaker G, Geller N, Gersh B, et al. (2004) Angiotensin-converting- enzyme inhibition in stable coronary artery disease. N Engl J Med 351:2058-2068.
4. Butcher EC (1991) Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67:1033-1036.
5. Chattopadhyay S, Santhamma KR, Sengupta S, McCue B, Kinter M, Sen GC, and Sen I (2005) Calmodulin binds to the cytoplasmic domain of angiotensin- converting enzyme and regulates its phosphorylation and cleavage secretion. J Biol Chem 280:33847-33855.
6. Chavakis T, May AE, Preissner KT, and Kanse SM (1999) Molecular mechanisms of zinc-dependent leukocyte adhesion involving the urokinase receptor and beta 2-integrins. Blood 93:2976-2983.
7. Chen R, Iwai M, Wu L, Suzuki J, Min LJ, Shiuchi T, Sugaya T, Liu HW, Cui TX, and Horiuchi M (2003) Important role of nitric oxide in the effect of angiotensin-converting enzyme inhibitor imidapril on vascular injury. Hypertension 42:542-547.
8. Csermely P, Szamel M, Resch K, and Somogyi J (1988) Zinc can increase the activity of protein kinase-C and contributes to its binding to plasma-membranes in lymphocytes-T. J Biol Chem 263:6487-6490.
9. Cushman DW and Ondetti MA (1999) Design of angiotensin converting enzyme inhibitors. Nat Med 5:1110-1112.
10. da Cunha V, Tham DM, Martin-McNulty B, Deng G, Ho JJ, Wilson DW, Rutledge JC, Vergona R, Sullivan ME, and Wang YX (2005) Enalapril attenuates angiotensin II-induced atherosclerosis and vascular inflammation. Atherosclerosis 178:9-17.
11. Fukuhara M, Geary RL, Diz DI, Gallagher PE, Wilson JA, Glazier SS, Dean RH, and Ferrario CM (2000) Angiotensin-converting enzyme expression in human carotid artery atherosclerosis. Hypertension 35:353-359.
12. Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA Jr, Luster AD, Luscinskas FW, and Rosenzweig A (1999) MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 398:718-723.
13. Golik A, Zaidenstein R, Dishi V, Blatt A, Cohen N, Cotter G, Berman S, and Weissgarten J (1998) Effects of captopril and enalapril on zinc metabolism in hypertensive patients. J Am Coll Nutr 17:75-78.
14. Haase H, Hebel S, Engelhardt G, and Rink L (2006) Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells. Anal Biochem 352:222-230.
15. Haase H and Rink L (2007) Signal transduction in monocytes: the role of zinc ions. Biometals 20:579-585.
16. Hayek T, Attias J, Coleman R, Brodsky S, Smith J, Breslow JL, and Keidar S (1999) The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E deficient mice. Cardiovasc Res 44:579-587.
17. Hiraoka M, Nitta N, Nagai M, Shimokado K, and Yoshida M (2004) MCP-1-induced enhancement of THP-1 adhesion to vascular endothelium was modulated by HMGCoA reductase inhibitor through RhoA GTPase-, but not ERK1/2-dependent pathway. Life Sci 75:1333-1341.
18. Kabu K, Yamasaki S, Kamimura D, Ito Y, Hasegawa A, Sato E, Kitamura H, Nishida K, and Hirano T (2006) Zinc is required for Fc epsilon RI-mediated mast cell activation. J Immunol 177:1296-1305.
19. Kawakami A, Tanaka A, Nakajima K, Shimokado K, and Yoshida M (2002) Atorvastatin attenuates remnant lipoprotein-induced monocyte adhesion to vascular endothelium under flow conditions. Circ Res 91:263-271.
20. Kitamura H, Morikawa H, Kamon H, Iguchi M, Hojyo S, Fukada T, Yamashita S, Kaisho T, Akira S, Murakami M, et al. (2006) Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat Immunol 7:971-977.
21. Klein CL, Kohler H, and Kirkpatrick CJ (1994) Increased adhesion and activation of polymorphonuclear neutrophil granulocytes to endothelial-cells under heavymetal exposure in-vitro. Pathobiology 62:90-98.
22. Kohlstedt K, Busse R, and Fleming I (2005) Signaling via the angiotensin-converting enzyme enhances the expression of cyclooxygenase-2 in endothelial cells. Hypertension 45:126-132.
23. Kowala MC, Grove RI, and Aberg G (1994) Inhibitors of angiotensin-converting enzyme decrease early atherosclerosis in hyperlipidemic hamsters. Fosinopril reduces plasma-cholesterol and captopril inhibits macrophage foam cell accumulation independently of blood-pressure and plasma-lipids. Atherosclerosis 108:61-72.
24. Libby P (2000) Changing concepts of atherogenesis. J Intern Med 247:349-358.
25. Lonn EM, Yusuf S, Dzavik V, Doris CI, Yi QL, Smith S, Moore-Cox A, Bosch J, Riley WA, Teo KK, et al. (2001) Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE). Circulation 103:919-925.
26. Martinotti S, Toniato E, Colagrande A, Alesse E, Alleva C, Screpanti I, Morrone S, Scarpa S, Frati L, Hayday AC, et al. (1995) Heavy-metal modulation of the human intercellular-adhesion molecule (ICAM-1) gene-expression. Biochim Biophys Acta 1261:107-114.
27. Metzger R, Bohle RM, Chumachenko P, Danilov SM, and Franke FE (2000) CD143 in the development of atherosclerosis. Atherosclerosis 150:21-31.
28. Reape TJ and Groot PHE (1999) Chemokines and atherosclerosis. Atherosclerosis 147:213-225.
29. Song K, Shiota N, Takai S, Takashima H, Iwasaki H, Kim S, and Miyazaki M (1998) Induction of angiotensin converting enzyme and angiotensin II receptors in the atherosclerotic aorta of high-cholesterol fed Cynomolgus monkeys. Atherosclerosis 138:171-182.
30. Takahashi K, Shimokado K, and Yoshida M (2006) SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition. Eur J Pharmacol 552:162-169.
31. Villard E, Alonso A, Agrapart M, Challah M, and Soubrier F (1998) Induction of angiotensin I-converting enzyme transcription by a protein kinase C-dependent mechanism in human endothelial cells. J Biol Chem 273:25191-25197.
32. Yoshida M, Sawada T, Ishii H, Gerszten RE, Rosenzweig A, Gimbrone MA, Yasukochi Y, and Numano F (2001) HMG-CoA reductase inhibitor modulates monocyteendothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism. Arterioscler Thromb Vasc Biol 21:1165-1171.
33. Yu T, Morita I, Shimokado K, Iwai T, and Yoshida M (2003) Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction. Hypertension 42:329-334.
34. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G, and Study HOPE (2000) Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 342:145-153.
35. Zalewski PD, Forbes IJ, Giannakis C, Cowled PA, and Betts WH (1990) Synergy between zinc and phorbol ester in translocation of protein-kinase-C to cytoskeleton. FEBS Lett 273:131-134.