Fabrication of chemically cross-linked porous gelatin matrices

Journal of Applied Biomaterials and Biomechanics

Volumn 7, Issue 3, 2009, Pages 194-199

  Bozzini, Sabrina ^a   Petrini, Paola ^a   Altomare, Lina ^a   Tanzi, Maria Cristina ^a  

^a POLITECNICO DI MILANO   (Italy)

Author keywords

Cross linking; Gelatin; Hydrogels; Tissue engineering

Indexed keywords

ALIPHATIC DIISOCYANATE; GELATIN; ISOCYANIC ACID DERIVATIVE; MOLECULAR SCAFFOLD; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CHEMICAL COMPOSITION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CROSS LINKING; FREEZE DRYING; HYDROGEL; MOLECULAR MECHANICS; NANOFABRICATION; PHYSICAL CHEMISTRY; POROSITY; STRUCTURE ANALYSIS; WATER TRANSPORT;

EID: 73149093619     PISSN: 17226899     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Danga JM, Leong KW. Natural polymers for gene delivery and tissue engineering. Adv Drug Deliv Rev 2006; 58: 487-99.
2. Peppas NA, Hilt JZ, Khademhosseini A, Langer R. Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv Mater 2006, 18, 1345-60.
3. Sutter M, Siepmann J, Hennink WE, et al. Recombinant gelatin hydrogels for the sustained release of proteins. J Control Release 2007, 119: 301-12.
4. K ozlov PV, Burdygina GI. The structure and properties of solid gelatin and the principles of their modification. Polymer 1983; 24: 651-66.
5. Dubruel P, Vlierberghe SV, Cnudde V, et al. Porous gelatin hydrogels: 2. In vitro cell interaction study. Biomacromolecules 2007; 8: 338-44.
6. Tabata Y, Ikada Y. Protein release from gelatine matrices. Adv Drug Deliv Rev 1998; 31: 287-301.
7. Schrieber R, Gareis H. Gelatine Handbook: Theory and Industrial Practice. Wiley-VCH Verlag, 2007.
8. Vlierberghe SV, Cnudde V, Dubruel P, et al. Porous gelatin hydrogels: 1. Cryogenic formation and structure analysis. Biomacromolecules 2007; 8: 331-7.
9. Bubnis WA, Ofner CM. The determination of e-amino groups in soluble and poorly proteinaceous materials by a spectrophotometric method using trinitrobenzenesulfonic acid. Analytical Biochemistry 1992; 207: 129-33.
10. Broderick EP, O'Halloran DM, Rochev YA, et al. Enzymatic stabilization of gelatin-based scaffolds. J Biomed Mater Res B Appl Biomater 2005; 72: 37-42.
11. K enchington AW, Ward AG. The titration curve of gelatine. Biochem J 1954; 58: 202-07.
12. Bertoldo M, Bronco S, Gragnoli T, et al. Modification of gelatin by reaction with 1,6-diisocyanatohexane. Biomacromolecules Bioscience 2007: 7: 328-38.
13. Peppas NA, Bures P, Leobandung W, et al. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 2000; 50: 27-46.
14. Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev 2002; 43: 3-12.
15. Bigi A, Cojazzi G, Panzavolta S, et al. Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking. Biomaterials 2001; 22: 763-8.
16. Meyvis TKL, Stubbe BG, Van Steenbergen MJ, et al. A comparison between the use of dynamic mechanical analysis and oscillatory shear rheometry for the characterisation of hydrogels. Int J Pharmaceutics 2002; 244: 163-8.