Human pluripotent stem cell and neural differentiation

Brain and Nerve

Volumn 60, Issue 10, 2008, Pages 1165-1172

  Wataya, Takafumi ^a   Muguruma, Keiko ^a   Sasai, Yoshiki ^a  

^a RIKEN Center for Biosystems Dynamics Research   (Japan)

Author keywords

Cell therapy; ES cell; Neural differentiation; ROCK inhibitor

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE;

BRAIN FUNCTION; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CLINICAL FEATURE; GRANULE CELL; HUMAN; HYPOTHALAMUS; MEDICAL ETHICS; NERVE REGENERATION; NONHUMAN; PARKINSON DISEASE; PHOTORECEPTOR CELL; PLURIPOTENT STEM CELL; PURKINJE CELL; RETINA CELL; REVIEW; STEM CELL TRANSPLANTATION; TELENCEPHALON; THERAPY EFFECT;

AMIDES; ANIMALS; APOPTOSIS; CELL AGGREGATION; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; DOPAMINE; EMBRYONIC STEM CELLS; ENZYME INHIBITORS; HUMANS; MICE; PARKINSON DISEASE; PLURIPOTENT STEM CELLS; PYRIDINES; REGENERATIVE MEDICINE; RHO-ASSOCIATED KINASES; TISSUE THERAPY;

EID: 54149085337     PISSN: 18816096     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (18)

1. Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, et al: Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest 115: 102-109, 2005
2. Morizane A, Takahashi J, Takagi Y, Sasai Y, Hashimoto N: Optimal conditions for in vivo induction of dopaminergic neurons from embryonic stem cells through stromal cell-derived inducing activity. J Neurosci Res 69: 934-939, 2002
3. Morizane A, Takahashi J, Shinoyama M, Ideguchi M, Takagi Y, et al: Generation of graftable dopaminergic neuron progenitors from mouse ES cells by a combination of coculture and neurosphere methods. J Neurosci Res 83: 1015-1027, 2006
4. German DC, Manaye KF, Sonsalla PK, Brooks BA: Midbrain dopaminergic cell loss in Parkinson's disease and MPTP-induced parkinsonism: sparing of calbindin-D28k-containing cells. Ann N Y Acad Sci 648: 42-62, 1992
5. Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, et al: Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 344: 710-719, 2001
6. Thompson L, Barraud P, Andersson E, Kirik D, Bjorklund A: Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. J Neurosci 25: 6467-6477, 2005
7. Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, et al: Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 28: 31-40, 2000
8. Kawasaki H, Suemori H, Mizuseki K, Watanabe K, Urano F, et al: Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proc Natl Acad Sci U S A 99: 1580-1585, 2002
9. Ueno M, Matsumura M, Watanabe K, Nakamura T. Osakada F, et al: Neural conversion of ES cells by an inductive activity on human amniotic membrane matrix. Proc Natl Acad Sci U S A 103: 9554-9559, 2006
10. Ono Y, Nakatani T, Sakamoto Y, Mizuhara E, Minaki Y, et al: Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development 134: 3213-3225, 2007
11. Watanabe K, Kamiya D, Nishiyama A, Katayama T, Nozaki S, et al: Directed differentiation of telencephalic precursors from embryonic stem cells. Nat Neurosci 8: 288-296, 2005
12. Ikeda H, Osakada F, Watanabe K, Mizuseki K, Haraguchi T, et al: Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci USA 102: 11331-11336, 2005
13. Su HL, Muguruma K, Matsuo-Takasaki M, Kengaku M, Watanabe K, et al: Generation of cerebellar neuron precursors from embryonic stem cells. Dev Biol 290: 287-296, 2006
14. Wataya T, Ando S, Muguruma K, Ikeda H, Watanabe K, et al: Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation. Proc Natl Acad Sci U S A, 2008 (in press)
15. Watanabe K, Ueno M, Kamiya D, Nishiyama A, Matsumura M, et al: A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol 25: 681-686, 2007
16. Hu E, Lee D: Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges. Expert Opin Ther Targets 9: 715-736, 2005
17. Koyanagi M, Takahashi J, Arakawa Y, Doi D, Fukuda H, et al: Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J Neurosci Res 86: 270-280, 2008
18. Minambres R, Guasch RM, Perez-Arago A, Guerri C: The RhoA/ROCK-I/MLC pathway is involved in the ethanol-induced apoptosis by anoikis in astrocytes. J Cell Sci 119: 271-282, 2006