Development of a high cell-density protocol for the production of pregallidermin, a non-toxic precursor of the lantibiotic gallidermin

Journal of Biotechnology

Volumn 145, Issue 2, 2010, Pages 176-185

  Medaglia, Giovanni ^a   Valsesia, Giorgia ^a   Panke, Sven ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Fermentation; Gallidermin; High cell density; Lantibiotics; Product inhibition; Staphylococcus

Indexed keywords

BIOMASS CONCENTRATIONS; BIOMASS PRODUCTIONS; CARBON SOURCE; COMPLEX MEDIA; EXPONENTIAL FEEDING; FED-BATCH CULTIVATION; FEEDING RATE; GRAM-POSITIVE PATHOGENS; LANTIBIOTICS; METHICILLIN; PRODUCT CONCENTRATION; PRODUCT DEGRADATION; PRODUCT INHIBITION; S. AUREUS; TWO-STAGE PRODUCTION;

FEEDING; FERMENTATION; GLYCEROL; TOXIC MATERIALS;

BIOMASS;

ACETIC ACID; GALLIDERMIN; GLYCEROL; LANTIBIOTIC; MALTOSE; PREGALLIDERMIN; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM CULTURE; BIOACCUMULATION; BIODEGRADATION; BIOMASS PRODUCTION; BIOTECHNOLOGICAL PRODUCTION; CARBON SOURCE; CELL DENSITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FED BATCH FERMENTATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STAPHYLOCOCCUS; STAPHYLOCOCCUS GALLINARUM;

BACTERIOCINS; BIOREACTORS; CELL COUNT; CELL CULTURE TECHNIQUES; COMPUTER SIMULATION; GENETIC ENHANCEMENT; MODELS, BIOLOGICAL; PEPTIDES; STAPHYLOCOCCUS;

POSIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS GALLINARUM;

EID: 72949105568     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2009.11.012     Document Type: Article

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