메뉴 건너뛰기




Volumn 171, Issue 1, 2010, Pages 1-13

Steroid 5-α-reductase type 2 (SRD5a2) gene polymorphisms and risk of prostate cancer: A HuGE review

Author keywords

Epidemiology; Genetic predisposition to disease; Genetics; Meta analysis; Polymorphism, genetic; Prostatic neoplasms; SRD5a2; Testosterone 5 alpha reductase

Indexed keywords

FINASTERIDE; PROSTATE SPECIFIC ANTIGEN; STEROID 5ALPHA REDUCTASE 2;

EID: 72949091442     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwp318     Document Type: Review
Times cited : (40)

References (78)
  • 2
    • 24644440563 scopus 로고    scopus 로고
    • The 5a-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population
    • Giwercman YL, Abrahamsson PA, Giwercman A, et al. The 5a-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population. Eur Urol. 2005;48(4): 679-685.
    • (2005) Eur Urol , vol.48 , Issue.4 , pp. 679-685
    • Giwercman, Y.L.1    Abrahamsson, P.A.2    Giwercman, A.3
  • 3
    • 21844447090 scopus 로고    scopus 로고
    • Associations between polymorphisms in the steroid 5-a reductase type II (SRD5A2) gene and benign prostatic hyperplasia and prostate cancer
    • Salam MT, Ursin G, Skinner EC, et al. Associations between polymorphisms in the steroid 5-a reductase type II (SRD5A2) gene and benign prostatic hyperplasia and prostate cancer. Urol Oncol. 2005;23(4):246-253.
    • (2005) Urol Oncol , vol.23 , Issue.4 , pp. 246-253
    • Salam, M.T.1    Ursin, G.2    Skinner, E.C.3
  • 4
    • 33846647414 scopus 로고    scopus 로고
    • 5a-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia
    • Hayes VM, Severi G, Padilla EJ, et al. 5a-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia. Int J Cancer. 2007; 120(4):776-780.
    • (2007) Int J Cancer , vol.120 , Issue.4 , pp. 776-780
    • Hayes, V.M.1    Severi, G.2    Padilla, E.J.3
  • 5
    • 34548217770 scopus 로고    scopus 로고
    • Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: An explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors
    • Cussenot O, Azzouzi AR, Nicolaiew N, et al. Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors. Eur Urol. 2007;52(4):1082-1087.
    • (2007) Eur Urol , vol.52 , Issue.4 , pp. 1082-1087
    • Cussenot, O.1    Azzouzi, A.R.2    Nicolaiew, N.3
  • 6
    • 33845287059 scopus 로고    scopus 로고
    • Systematic replication study of reported genetic associations in prostate cancer: Strong support for genetic variation in the androgen pathway
    • Lindström S, Zheng SL, Wiklund F, et al. Systematic replication study of reported genetic associations in prostate cancer: strong support for genetic variation in the androgen pathway. Prostate. 2006;66(16):1729-1743.
    • (2006) Prostate , vol.66 , Issue.16 , pp. 1729-1743
    • Lindström, S.1    Zheng, S.L.2    Wiklund, F.3
  • 7
    • 0038286418 scopus 로고    scopus 로고
    • Association of V89L SRD5A2 polymorphism with prostate cancer development in a Japanese population
    • Li Z, Habuchi T, Mitsumori K, et al. Association of V89L SRD5A2 polymorphism with prostate cancer development in a Japanese population. J Urol. 2003;169(6):2378-2381.
    • (2003) J Urol , vol.169 , Issue.6 , pp. 2378-2381
    • Li, Z.1    Habuchi, T.2    Mitsumori, K.3
  • 8
    • 34547510624 scopus 로고    scopus 로고
    • Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    • Gudmundsson J, Sulem P, Steinthorsdottir V, et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet. 2007; 39(8):977-983.
    • (2007) Nat Genet , vol.39 , Issue.8 , pp. 977-983
    • Gudmundsson, J.1    Sulem, P.2    Steinthorsdottir, V.3
  • 9
    • 34247563453 scopus 로고    scopus 로고
    • Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
    • Gudmundsson J, Sulem P, Manolescu A, et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet. 2007;39(5):631-637.
    • (2007) Nat Genet , vol.39 , Issue.5 , pp. 631-637
    • Gudmundsson, J.1    Sulem, P.2    Manolescu, A.3
  • 10
    • 35748974205 scopus 로고    scopus 로고
    • A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study [electronic article]
    • Murabito JM, Rosenberg CL, Finger D, et al. A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study [electronic article]. BMC Med Genet. 2007;8(suppl 1):S6.
    • (2007) BMC Med Genet , vol.8 , Issue.SUPPL. 1
    • Murabito, J.M.1    Rosenberg, C.L.2    Finger, D.3
  • 11
    • 50649087219 scopus 로고    scopus 로고
    • A genome-wide association screen identifies regions on chromosomes 1q25 and 7p21 as risk loci for sporadic prostate cancer
    • Nam RK, Zhang WW, Loblaw DA, et al. A genome-wide association screen identifies regions on chromosomes 1q25 and 7p21 as risk loci for sporadic prostate cancer. Prostate Cancer Prostatic Dis. 2007;11(3):241-246.
    • (2007) Prostate Cancer Prostatic Dis , vol.11 , Issue.3 , pp. 241-246
    • Nam, R.K.1    Zhang, W.W.2    Loblaw, D.A.3
  • 12
    • 0029093031 scopus 로고
    • Genetic variability of the human SRD5A2 gene: Implications for prostate cancer risk
    • Reichardt JK, Makridakis N, Henderson BE, et al. Genetic variability of the human SRD5A2 gene: implications for prostate cancer risk. Cancer Res. 1995;55(18):3973-3975.
    • (1995) Cancer Res , vol.55 , Issue.18 , pp. 3973-3975
    • Reichardt, J.K.1    Makridakis, N.2    Henderson, B.E.3
  • 13
    • 0032532090 scopus 로고    scopus 로고
    • Androgen metabolism and prostate cancer: Establishing a model of genetic susceptibility
    • Ross RK, Pike MC, Coetzee GA, et al. Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility. Cancer Res. 1998;58(20):4497-4504.
    • (1998) Cancer Res , vol.58 , Issue.20 , pp. 4497-4504
    • Ross, R.K.1    Pike, M.C.2    Coetzee, G.A.3
  • 14
    • 0033974677 scopus 로고    scopus 로고
    • Molecular basis of androgen receptor diseases
    • Yong EL, Lim J, Qi W, et al. Molecular basis of androgen receptor diseases. Ann Med. 2000;32(1):15-22.
    • (2000) Ann Med , vol.32 , Issue.1 , pp. 15-22
    • Yong, E.L.1    Lim, J.2    Qi, W.3
  • 15
    • 0031077802 scopus 로고    scopus 로고
    • Basic science aspects of prostate cancer
    • Dorkin TJ, Neal DE. Basic science aspects of prostate cancer. Semin Cancer Biol. 1997;8(1):21-27.
    • (1997) Semin Cancer Biol , vol.8 , Issue.1 , pp. 21-27
    • Dorkin, T.J.1    Neal, D.E.2
  • 16
    • 0030890995 scopus 로고    scopus 로고
    • Polymorphic repeats in the androgen receptor gene: Molecular markers of prostate cancer risk
    • Stanford JL, Just JJ, Gibbs M, et al. Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res. 1997;57(6):1194-1198.
    • (1997) Cancer Res , vol.57 , Issue.6 , pp. 1194-1198
    • Stanford, J.L.1    Just, J.J.2    Gibbs, M.3
  • 17
    • 0347759927 scopus 로고    scopus 로고
    • Molecular epidemiology of androgen-metabolic loci in prostate cancer: Predisposition and progression
    • Makridakis NM, Reichardt JK. Molecular epidemiology of androgen-metabolic loci in prostate cancer: predisposition and progression. J Urol. 2004;171(2):S25-S28.
    • (2004) J Urol , vol.171 , Issue.2
    • Makridakis, N.M.1    Reichardt, J.K.2
  • 18
    • 0034801570 scopus 로고    scopus 로고
    • Molecular epidemiology of hormone-metabolic loci in prostate cancer
    • Makridakis NM, Reichardt JK. Molecular epidemiology of hormone-metabolic loci in prostate cancer. Epidemiol Rev. 2001;23(1):24-29.
    • (2001) Epidemiol Rev , vol.23 , Issue.1 , pp. 24-29
    • Makridakis, N.M.1    Reichardt, J.K.2
  • 20
    • 0037812658 scopus 로고    scopus 로고
    • The influence of finasteride on the development of prostate cancer
    • Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med. 2003;349(3):215-224.
    • (2003) N Engl J Med , vol.349 , Issue.3 , pp. 215-224
    • Thompson, I.M.1    Goodman, P.J.2    Tangen, C.M.3
  • 21
    • 39149084101 scopus 로고    scopus 로고
    • Endogenous sex hormones and prostate cancer: A collaborative analysis of 18 prospective studies
    • Roddam AW, Allen NE, Appleby P, et al. Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies. J Natl Cancer Inst. 2008;100(3): 170-183.
    • (2008) J Natl Cancer Inst , vol.100 , Issue.3 , pp. 170-183
    • Roddam, A.W.1    Allen, N.E.2    Appleby, P.3
  • 22
    • 58149512149 scopus 로고    scopus 로고
    • Testosterone therapy in hypogonadal men and potential prostate cancer risk: A systematic review
    • Shabsigh R, Crawford ED, Nehra A, et al. Testosterone therapy in hypogonadal men and potential prostate cancer risk: a systematic review. Int J Impot Res. 2009;21(1):9-23.
    • (2009) Int J Impot Res , vol.21 , Issue.1 , pp. 9-23
    • Shabsigh, R.1    Crawford, E.D.2    Nehra, A.3
  • 23
    • 0030938257 scopus 로고    scopus 로고
    • A prevalent missense substitution that modulates activity of prostatic steroid 5a-reductase
    • Makridakis N, Ross RK, Pike MC, et al. A prevalent missense substitution that modulates activity of prostatic steroid 5a-reductase. Cancer Res. 1997;57(6):1020-1022.
    • (1997) Cancer Res , vol.57 , Issue.6 , pp. 1020-1022
    • Makridakis, N.1    Ross, R.K.2    Pike, M.C.3
  • 24
    • 21344463569 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of human steroid 5a reductase type II: Comparison of finasteride and dutasteride
    • Makridakis N, Reichardt JK. Pharmacogenetic analysis of human steroid 5a reductase type II: comparison of finasteride and dutasteride. J Mol Endocrinol. 2005;34(3):617-623.
    • (2005) J Mol Endocrinol , vol.34 , Issue.3 , pp. 617-623
    • Makridakis, N.1    Reichardt, J.K.2
  • 25
    • 0033936410 scopus 로고    scopus 로고
    • Biochemical and pharmacogenetic dissection of human steroid 5a-reductase type II
    • Makridakis NM, di Salle E, Reichardt JK. Biochemical and pharmacogenetic dissection of human steroid 5a-reductase type II. Pharmacogenetics. 2000;10(5):407-413.
    • (2000) Pharmacogenetics , vol.10 , Issue.5 , pp. 407-413
    • Makridakis, N.M.1    Di Salle, E.2    Reichardt, J.K.3
  • 26
    • 0033581453 scopus 로고    scopus 로고
    • Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles United States
    • Makridakis NM, Ross RK, Pike MC, et al. Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, United States. Lancet. 1999;354(9183):975-978.
    • (1999) Lancet , vol.354 , Issue.9183 , pp. 975-978
    • Makridakis, N.M.1    Ross, R.K.2    Pike, M.C.3
  • 27
    • 0030974511 scopus 로고    scopus 로고
    • A polymorphism of the 5a-reductase gene and its association with prostate cancer: A case-control analysis
    • Kantoff PW, Febbo PG, Giovannucci E, et al. A polymorphism of the 5a-reductase gene and its association with prostate cancer: a case-control analysis. Cancer Epidemiol Biomarkers Prev. 1997;6(3):189-192.
    • (1997) Cancer Epidemiol Biomarkers Prev , vol.6 , Issue.3 , pp. 189-192
    • Kantoff, P.W.1    Febbo, P.G.2    Giovannucci, E.3
  • 28
    • 18744393366 scopus 로고    scopus 로고
    • Ethnic differences in the frequency of prostate cancer susceptibility alleles at SRD5A2 and CYP3A4
    • Zeigler-Johnson CM, Walker AH, Mancke B, et al. Ethnic differences in the frequency of prostate cancer susceptibility alleles at SRD5A2 and CYP3A4. Hum Hered. 2002;54(1): 13-21.
    • (2002) Hum Hered , vol.54 , Issue.1 , pp. 13-21
    • Zeigler-Johnson, C.M.1    Walker, A.H.2    Mancke, B.3
  • 29
    • 0037426058 scopus 로고    scopus 로고
    • Prostate cancer epidemiology
    • Grönberg H. Prostate cancer epidemiology. Lancet. 2003; 361(9360):859-864.
    • (2003) Lancet , vol.361 , Issue.9360 , pp. 859-864
    • Grönberg, H.1
  • 30
    • 41549113035 scopus 로고    scopus 로고
    • US Cancer Statistics Working Group Atlanta, GA, and Bethesda, MD: Centers for Disease Control and Prevention and National Cancer Institute
    • US Cancer Statistics Working Group. United States Cancer Statistics: 2004 Incidence and Mortality. Atlanta, GA, and Bethesda, MD: Centers for Disease Control and Prevention and National Cancer Institute, 2007.
    • (2007) United States Cancer Statistics: 2004 Incidence and Mortality
  • 31
    • 0037014792 scopus 로고    scopus 로고
    • Overdiagnosis due to prostate-specific antigen screening: Lessons from U.S. prostate cancer incidence trends
    • Etzioni R, Penson DF, Legler JM, et al. Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends. J Natl Cancer Inst. 2002;94(13): 981-990.
    • (2002) J Natl Cancer Inst , vol.94 , Issue.13 , pp. 981-990
    • Etzioni, R.1    Penson, D.F.2    Legler, J.M.3
  • 32
    • 0037471849 scopus 로고    scopus 로고
    • Screening for prostate cancer
    • Frankel S, Smith GD, Donovan J, et al. Screening for prostate cancer. Lancet. 2003;361(9363):1122-1128.
    • (2003) Lancet , vol.361 , Issue.9363 , pp. 1122-1128
    • Frankel, S.1    Smith, G.D.2    Donovan, J.3
  • 33
    • 33144488630 scopus 로고    scopus 로고
    • Prevalent mutations in prostate cancer
    • Dong JT. Prevalent mutations in prostate cancer. J Cell Bio-chem. 2006;97(3):433-447.
    • (2006) J Cell Bio-chem , vol.97 , Issue.3 , pp. 433-447
    • Dong, J.T.1
  • 34
    • 40049098166 scopus 로고    scopus 로고
    • Cumulative association of five genetic variants with prostate cancer
    • Zheng SL, Sun J, Wiklund F, et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med. 2008;358(9):910-919.
    • (2008) N Engl J Med , vol.358 , Issue.9 , pp. 910-919
    • Zheng, S.L.1    Sun, J.2    Wiklund, F.3
  • 36
    • 66649133395 scopus 로고    scopus 로고
    • Replication of the 10q11 and Xp11 prostate cancer risk variants: Results from a Utah pedigree-based study
    • Camp NJ, Farnham JM, Wong J, et al. Replication of the 10q11 and Xp11 prostate cancer risk variants: results from a Utah pedigree-based study. Cancer Epidemiol Biomarkers Prev. 2009;18(4):1290-1294.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , Issue.4 , pp. 1290-1294
    • Camp, N.J.1    Farnham, J.M.2    Wong, J.3
  • 37
    • 33645999062 scopus 로고    scopus 로고
    • A systematic review of vitamin D receptor gene polymorphisms and prostate cancer risk
    • Berndt SI, Dodson JL, Huang WY, et al. A systematic review of vitamin D receptor gene polymorphisms and prostate cancer risk. J Urol. 2006;175(5):1613-1623.
    • (2006) J Urol , vol.175 , Issue.5 , pp. 1613-1623
    • Berndt, S.I.1    Dodson, J.L.2    Huang, W.Y.3
  • 38
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-188.
    • (1986) Control Clin Trials , vol.7 , Issue.3 , pp. 177-188
    • Dersimonian, R.1    Laird, N.2
  • 39
    • 84948773232 scopus 로고    scopus 로고
    • Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis
    • Egger M, Davey Smith G, Altman DG, eds. 2nd ed. London, United Kingdom: BMJ Books
    • Deeks JJ, Altman DG, Bradburn MJ. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M, Davey Smith G, Altman DG, eds. Systematic Reviews in Health Care: Meta-Analysis in Context. 2nd ed. London, United Kingdom: BMJ Books; 2005:285-312.
    • (2005) Systematic Reviews in Health Care: Meta-Analysis in Context , pp. 285-312
    • Deeks, J.J.1    Altman, D.G.2    Bradburn, M.J.3
  • 40
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4): 1088-1101.
    • (1994) Biometrics , vol.50 , Issue.4 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 42
    • 0025215247 scopus 로고
    • Power and sample size calculations. A review and computer program
    • Dupont WD, Plummer WD Jr. Power and sample size calculations. A review and computer program. Control Clin Trials. 1990;11(2):116-128.
    • (1990) Control Clin Trials , vol.11 , Issue.2 , pp. 116-128
    • Dupont, W.D.1    Jr P.Wd2
  • 43
    • 0036120288 scopus 로고    scopus 로고
    • Steroid 5-a reductase type II V89L substitution is not associated with risk of prostate cancer in a multiethnic population study
    • Pearce CL, Makridakis NM, Ross RK, et al. Steroid 5-a reductase type II V89L substitution is not associated with risk of prostate cancer in a multiethnic population study. Cancer Epidemiol Biomarkers Prev. 2002;11(4):417-418.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , Issue.4 , pp. 417-418
    • Pearce, C.L.1    Makridakis, N.M.2    Ross, R.K.3
  • 44
    • 0035156454 scopus 로고    scopus 로고
    • V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progression
    • Nam RK, Toi A, Vesprini D, et al. V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progression. Urology. 2001;57(1): 199-204.
    • (2001) Urology , vol.57 , Issue.1 , pp. 199-204
    • Nam, R.K.1    Toi, A.2    Vesprini, D.3
  • 45
    • 9144263792 scopus 로고    scopus 로고
    • Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancer
    • Nam RK, Zhang WW, Trachtenberg J, et al. Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2003;12(12):1429-1437.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , Issue.12 , pp. 1429-1437
    • Nam, R.K.1    Zhang, W.W.2    Trachtenberg, J.3
  • 46
    • 33845288374 scopus 로고    scopus 로고
    • Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-a-reductase type 2 is important for prostate cancer development
    • Lindström S, Wiklund F, Adami HO, et al. Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-a-reductase type 2 is important for prostate cancer development. Cancer Res. 2006; 66(22):11077-11083.
    • (2006) Cancer Res , vol.66 , Issue.22 , pp. 11077-11083
    • Lindström, S.1    Wiklund, F.2    Adami, H.O.3
  • 47
    • 48249097794 scopus 로고    scopus 로고
    • No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: Lessons learned
    • Pearce CL, Van Den Berg DJ, Makridakis N, et al. No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learned. Hum Mol Genet. 2008; 17(16):2456-2461.
    • (2008) Hum Mol Genet , vol.17 , Issue.16 , pp. 2456-2461
    • Pearce, C.L.1    Van Den Berg, D.J.2    Makridakis, N.3
  • 48
    • 0032846313 scopus 로고    scopus 로고
    • Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reduc-tase (SRD5A2)
    • Lunn RM, Bell DA, Mohler JL, et al. Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reduc-tase (SRD5A2). Carcinogenesis. 1999;20(9):1727-1731.
    • (1999) Carcinogenesis , vol.20 , Issue.9 , pp. 1727-1731
    • Lunn, R.M.1    Bell, D.A.2    Mohler, J.L.3
  • 49
    • 0035371666 scopus 로고    scopus 로고
    • Impact of genetic polymorphisms of 17-hydroxylase cytochrome P-450 (CYP17) and steroid 5a-reductase type II (SRD5A2) genes on prostate-cancer risk among the Japanese population
    • Yamada Y, Watanabe M, Murata M, et al. Impact of genetic polymorphisms of 17-hydroxylase cytochrome P-450 (CYP17) and steroid 5a-reductase type II (SRD5A2) genes on prostate-cancer risk among the Japanese population. Int J Cancer. 2001; 92(5):683-686.
    • (2001) Int J Cancer , vol.92 , Issue.5 , pp. 683-686
    • Yamada, Y.1    Watanabe, M.2    Murata, M.3
  • 50
    • 35649003890 scopus 로고    scopus 로고
    • SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness
    • Neslund-Dudas C, Bock CH, Monaghan K, et al. SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness. Prostate. 2007;67(15):1654-1663.
    • (2007) Prostate , vol.67 , Issue.15 , pp. 1654-1663
    • Neslund-Dudas, C.1    Bock, C.H.2    Monaghan, K.3
  • 51
    • 0034788128 scopus 로고    scopus 로고
    • Polymorphic markers in the SRD5A2 gene and prostate cancer risk: A population-based case-control study
    • Hsing AW, Chen C, Chokkalingam AP, et al. Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study. Cancer Epidemiol Bio-markers Prev. 2001;10(10):1077-1082.
    • (2001) Cancer Epidemiol Bio-markers Prev , vol.10 , Issue.10 , pp. 1077-1082
    • Hsing, A.W.1    Chen, C.2    Chokkalingam, A.P.3
  • 52
    • 33846565998 scopus 로고    scopus 로고
    • Variant in sex hormone-binding globulin gene and the risk of prostate cancer
    • Berndt SI, Chatterjee N, Huang WY, et al. Variant in sex hormone-binding globulin gene and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007;16(1):165-168.
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , Issue.1 , pp. 165-168
    • Berndt, S.I.1    Chatterjee, N.2    Huang, W.Y.3
  • 53
    • 33847690738 scopus 로고    scopus 로고
    • The association of 5a-reductase II (SRD5A2) and 17 hydroxylase (CYP17) gene polymorphisms with prostate cancer patients in the Turkish population
    • Onen IH, Ekmekci A, Eroglu M, et al. The association of 5a-reductase II (SRD5A2) and 17 hydroxylase (CYP17) gene polymorphisms with prostate cancer patients in the Turkish population. DNA Cell Biol. 2007;26(2):100-107.
    • (2007) DNA Cell Biol , vol.26 , Issue.2 , pp. 100-107
    • Onen, I.H.1    Ekmekci, A.2    Eroglu, M.3
  • 54
    • 0034436935 scopus 로고    scopus 로고
    • Evidence for an association between the SRD5A2 (type II steroid 5 alpha-reductase) locus and prostate cancer in Italian patients
    • Margiotti K, Sangiuolo F, De Luca A, et al. Evidence for an association between the SRD5A2 (type II steroid 5 alpha-reductase) locus and prostate cancer in Italian patients. Dis Markers. 2000;16(3-4):147-150.
    • (2000) Dis Markers , vol.16 , Issue.3-4 , pp. 147-150
    • Margiotti, K.1    Sangiuolo, F.2    De Luca, A.3
  • 55
    • 0035906834 scopus 로고    scopus 로고
    • A missense substitution A49T in the steroid 5-alpha-reductase gene (SRD5A2) is not associated with prostate cancer in Finland
    • Mononen N, Ikonen T, Syrjäkoski K, et al. A missense substitution A49T in the steroid 5-alpha-reductase gene (SRD5A2) is not associated with prostate cancer in Finland. Br J Cancer. 2001;84(10):1344-1347.
    • (2001) Br J Cancer , vol.84 , Issue.10 , pp. 1344-1347
    • Mononen, N.1    Ikonen, T.2    Syrjäkoski, K.3
  • 56
    • 34250312727 scopus 로고    scopus 로고
    • Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer
    • Cunningham JM, Hebbring SJ, McDonnell SK, et al. Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007; 16(5):969-978.
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , Issue.5 , pp. 969-978
    • Cunningham, J.M.1    Hebbring, S.J.2    McDonnell, S.K.3
  • 57
    • 0036016312 scopus 로고    scopus 로고
    • 5a-Reductase 2 polymorphisms as risk factors in prostate cancer
    • Söderström T, Wadelius M, Andersson SO, et al. 5a-Reductase 2 polymorphisms as risk factors in prostate cancer. Pharma-cogenetics. 2002;12(4):307-312.
    • (2002) Pharma-cogenetics , vol.12 , Issue.4 , pp. 307-312
    • Söderström, T.1    Wadelius, M.2    Andersson, S.O.3
  • 58
    • 0033233173 scopus 로고    scopus 로고
    • The V89L polymorphism in the 5a-reductase type 2 gene and risk of prostate cancer
    • Febbo PG, Kantoff PW, Platz EA, et al. The V89L polymorphism in the 5a-reductase type 2 gene and risk of prostate cancer. Cancer Res. 1999;59(23):5878-5881.
    • (1999) Cancer Res , vol.59 , Issue.23 , pp. 5878-5881
    • Febbo, P.G.1    Kantoff, P.W.2    Platz, E.A.3
  • 59
    • 0035446824 scopus 로고    scopus 로고
    • Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways
    • Latil AG, Azzouzi R, Cancel GS, et al. Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways. Cancer. 2001;92(5):1130-1137.
    • (2001) Cancer , vol.92 , Issue.5 , pp. 1130-1137
    • Latil, A.G.1    Azzouzi, R.2    Cancel, G.S.3
  • 60
    • 0038662817 scopus 로고    scopus 로고
    • Polymorphic markers in the 5a-reductase type II gene and the incidence of prostate cancer
    • Lamharzi N, Johnson MM, Goodman G, et al. Polymorphic markers in the 5a-reductase type II gene and the incidence of prostate cancer. Int J Cancer. 2003;105(4):480-483.
    • (2003) Int J Cancer , vol.105 , Issue.4 , pp. 480-483
    • Lamharzi, N.1    Johnson, M.M.2    Goodman, G.3
  • 61
    • 0037904921 scopus 로고    scopus 로고
    • Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer
    • Chang BL, Zheng SL, Isaacs SD, et al. Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer. Prostate. 2003;56(1):37-44.
    • (2003) Prostate , vol.56 , Issue.1 , pp. 37-44
    • Chang, B.L.1    Zheng, S.L.2    Isaacs, S.D.3
  • 62
    • 33744824667 scopus 로고    scopus 로고
    • CYP17, SRD5A2, CYP1B1, and CYP2D6 gene polymorphisms with prostate cancer risk in North Indian population
    • Sobti RC, Onsory K, Al-Badran AI, et al. CYP17, SRD5A2, CYP1B1, and CYP2D6 gene polymorphisms with prostate cancer risk in North Indian population. DNA Cell Biol. 2006; 25(5):287-294.
    • (2006) DNA Cell Biol , vol.25 , Issue.5 , pp. 287-294
    • Sobti, R.C.1    Onsory, K.2    Al-Badran, A.I.3
  • 63
    • 30044440451 scopus 로고    scopus 로고
    • Genotyping errors: Causes, consequences and solutions
    • Pompanon F, Bonin A, Bellemain E, et al. Genotyping errors: causes, consequences and solutions. Nat Rev Genet. 2005; 6(11):847-859.
    • (2005) Nat Rev Genet , vol.6 , Issue.11 , pp. 847-859
    • Pompanon, F.1    Bonin, A.2    Bellemain, E.3
  • 64
    • 33745276855 scopus 로고    scopus 로고
    • Bayesian graphical models for genomewide association studies
    • Verzilli CJ, Stallard N, Whittaker JC. Bayesian graphical models for genomewide association studies. Am J Hum Genet. 2006;79(1):100-112.
    • (2006) Am J Hum Genet , vol.79 , Issue.1 , pp. 100-112
    • Verzilli, C.J.1    Stallard, N.2    Whittaker, J.C.3
  • 65
    • 0035732936 scopus 로고    scopus 로고
    • The association between polymorphisms in the CYP17 and 5a-reductase (SRD5A2) genes and serum androgen concentrations in men
    • Allen NE, Forrest MS, Key TJ. The association between polymorphisms in the CYP17 and 5a-reductase (SRD5A2) genes and serum androgen concentrations in men. Cancer Epidemiol Biomarkers Prev. 2001;10(3):185-189.
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , Issue.3 , pp. 185-189
    • Allen, N.E.1    Forrest, M.S.2    Key, T.J.3
  • 66
    • 0037782049 scopus 로고    scopus 로고
    • Association between two polymorphisms in the SRD5A2 gene and serum androgen concentrations in British men
    • Allen NE, Reichardt JK, Nguyen H, et al. Association between two polymorphisms in the SRD5A2 gene and serum androgen concentrations in British men. Cancer Epidemiol Biomarkers Prev. 2003;12(6):578-581.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , Issue.6 , pp. 578-581
    • Allen, N.E.1    Reichardt, J.K.2    Nguyen, H.3
  • 67
    • 0032412702 scopus 로고    scopus 로고
    • Combined orchiec-tomy and external radiotherapy versus radiotherapy alone for nonmetastatic prostate cancer with or without pelvic lymph node involvement: A prospective randomized study
    • Granfors T, Modig H, Damber JE, et al. Combined orchiec-tomy and external radiotherapy versus radiotherapy alone for nonmetastatic prostate cancer with or without pelvic lymph node involvement: a prospective randomized study. J Urol. 1998;159(6):2030-2034.
    • (1998) J Urol , vol.159 , Issue.6 , pp. 2030-2034
    • Granfors, T.1    Modig, H.2    Damber, J.E.3
  • 68
    • 13344249723 scopus 로고    scopus 로고
    • Evaluation of adjuvant estramustine phosphate, cyclophosphamide, and observation only for node-positive patients following radical prostatectomy and definitive irradiation. Investigators of the National Prostate Cancer Project
    • Schmidt JD, Gibbons RP, Murphy GP, et al. Evaluation of adjuvant estramustine phosphate, cyclophosphamide, and observation only for node-positive patients following radical prostatectomy and definitive irradiation. Investigators of the National Prostate Cancer Project. Prostate. 1996;28(1):51-57.
    • (1996) Prostate , vol.28 , Issue.1 , pp. 51-57
    • Schmidt, J.D.1    Gibbons, R.P.2    Murphy, G.P.3
  • 69
    • 51049123617 scopus 로고    scopus 로고
    • Preventing prostate cancer: New analyses put finas-teride back on the map
    • Vastag B. Preventing prostate cancer: new analyses put finas-teride back on the map. J Natl Cancer Inst. 2008;100(16): 1132-1133.
    • (2008) J Natl Cancer Inst , vol.100 , Issue.16 , pp. 1132-1133
    • Vastag, B.1
  • 70
    • 68349146348 scopus 로고    scopus 로고
    • GWAS meets mi-croarray: Are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example [electronic article]
    • Gorlov IP, Gallick GE, Gorlova OY, et al. GWAS meets mi-croarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example [electronic article]. PLoS One. 2009;4(8):e6511.
    • (2009) PLoS One , vol.4 , Issue.8
    • Gorlov, I.P.1    Gallick, G.E.2    Gorlova, O.Y.3
  • 71
    • 38949094880 scopus 로고    scopus 로고
    • Assessment of cumulative evidence on genetic associations: Interim guidelines
    • Ioannidis JP, Boffetta P, Little J, et al. Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol. 2008;37(1):120-132.
    • (2008) Int J Epidemiol , vol.37 , Issue.1 , pp. 120-132
    • Ioannidis, J.P.1    Boffetta, P.2    Little, J.3
  • 72
    • 33748804424 scopus 로고    scopus 로고
    • A tutorial on statistical methods for population association studies
    • Balding DJ. A tutorial on statistical methods for population association studies. Nat Rev Genet. 2006;7(10):781-791.
    • (2006) Nat Rev Genet , vol.7 , Issue.10 , pp. 781-791
    • Balding, D.J.1
  • 74
    • 1642284253 scopus 로고    scopus 로고
    • Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2 CYP17 and the AR
    • Cicek MS, Conti DV, Curran A, et al. Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2, CYP17, and the AR. Prostate. 2004;59(1):69-76.
    • (2004) Prostate , vol.59 , Issue.1 , pp. 69-76
    • Cicek, M.S.1    Conti, D.V.2    Curran, A.3
  • 75
    • 20444474154 scopus 로고    scopus 로고
    • Association between hormonal genetic polymorphisms and early-onset prostate cancer
    • Forrest MS, Edwards SM, Houlston R, et al. Association between hormonal genetic polymorphisms and early-onset prostate cancer. Prostate Cancer Prostatic Dis. 2005;8(1): 95-102.
    • (2005) Prostate Cancer Prostatic Dis , vol.8 , Issue.1 , pp. 95-102
    • Forrest, M.S.1    Edwards, S.M.2    Houlston, R.3
  • 76
    • 0033304531 scopus 로고    scopus 로고
    • Hormonal signaling in prostatic hyperplasia and neoplasia
    • Marcelli M, Cunningham GR. Hormonal signaling in prostatic hyperplasia and neoplasia. J Clin Endocrinol Metab. 1999; 84(10):3463-3468.
    • (1999) J Clin Endocrinol Metab , vol.84 , Issue.10 , pp. 3463-3468
    • Marcelli, M.1    Cunningham, G.R.2
  • 77
    • 0036602805 scopus 로고    scopus 로고
    • Association of polymorphisms within androgen receptor, 5a-reductase, and PSA genes with prostate volume, clinical parameters, and endocrine status in elderly men
    • Schatzl G, Madersbacher S, Gsur A, et al. Association of polymorphisms within androgen receptor, 5a-reductase, and PSA genes with prostate volume, clinical parameters, and endocrine status in elderly men. Prostate. 2002;52(2): 130-138.
    • (2002) Prostate , vol.52 , Issue.2 , pp. 130-138
    • Schatzl, G.1    Madersbacher, S.2    Gsur, A.3
  • 78
    • 41149166182 scopus 로고    scopus 로고
    • Prostate-specific antigen and prostate cancer: Prediction, detection and monitoring
    • Lilja H, Ulmert D, Vickers AJ. Prostate-specific antigen and prostate cancer: prediction, detection and monitoring. Nat Rev Cancer. 2008;8(4):268-278.
    • (2008) Nat Rev Cancer , vol.8 , Issue.4 , pp. 268-278
    • Lilja, H.1    Ulmert, D.2    Vickers, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.