A genome-wide association screen identifies regions on chromosomes 1q25 and 7p21 as risk loci for sporadic prostate cancer

Prostate Cancer and Prostatic Diseases

Volumn 11, Issue 3, 2008, Pages 241-246

  Nam, R K ^a   Zhang, W W ^a   Loblaw, D A ^a   Klotz, L H ^a   Trachtenberg, J ^b   Jewett, M A S ^b   Stanimirovic, A ^a   Davies, T O ^a   Toi, A ^b   Venkateswaran, V ^a   Sugar, L ^a   Siminovitch, K A ^c   Narod, S A ^d  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PANCREATIC RIBONUCLEASE; TRANSCRIPTION FACTOR ER81;

ADULT; ALLELE; ARTICLE; CANCER PATIENT; CANCER RISK; CANCER SCREENING; CHROMOSOME 1Q; CHROMOSOME 7P; CONTROLLED STUDY; GENE LOCUS; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SCREENING; GENETIC VARIABILITY; HAPLOTYPE MAP; HUMAN; HUMAN CELL; INHERITANCE; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROSTATE BIOPSY; PROSTATE CANCER; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM;

CASE-CONTROL STUDIES; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 7; FAMILY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOME, HUMAN; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATIC NEOPLASMS; RISK FACTORS;

EID: 50649087219     PISSN: 13657852     EISSN: 14765608     Source Type: Journal    
DOI: 10.1038/sj.pcan.4501010     Document Type: Article

References (21)

1. Schaid DJ. The complex genetic epidemiology of prostate cancer. Hum Mol Genet 2004; 13 (Spec No 1): R103-R121.
2. Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J et al. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet 2002; 30: 181-184.
3. Noonan-Wheeler FC, Wu W, Roehl KA, Klim A, Haugen J, Suarez BK et al. Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma. Prostate 2006; 66 49-56.
4. Vesprini D, Nam RK, Trachtenberg J, Jewett MAS, Tavtigian SV, Emami M et al. HPC2 variants and screen-detected prostate cancer. Am J Hum Genet 2001; 68: 912-917.
5. Zhao X, Li C, Paez JG, Chin K, Janne PA, Chen TH et al. An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Res 2004; 64: 3060-3071.
6. Wong KK, Tsang YT, Shen J, Cheng RS, Chang YM, Man TK et al. Allelic imbalance analysis by high-density single-nucleotide polymorphic allele (SNP) array with whole genome amplified DNA. Nucleic Acids Res 2004; 32: E69.
7. Hu N, Wang C, Hu Y, Yang HH, Giffen C, Tang ZZ et al. Genome-wide association study in esophageal cancer using GeneChip mapping 10 K array. Cancer Res 2005; 65: 2542-2546.
8. Roehl KA, Loeb S, Antenor JA, Corbin N, Catalona WJ. Characteristics of patients with familial versus sporadic prostate cancer. J Urol 2006; 176 (Part 1): 2438-2442; discussion 42.
9. Nam RK, Zhang WW, Jewett MA, Trachtenberg J, Klotz LH, Emami M et al. The use of genetic markers to determine risk for prostate cancer at prostate biopsy. Clin Cancer Res 2005; 11: 8391-8397.
10. Nam RK, Zhang W, Jewett MAS, Emami M, Vesprini D, Chu W et al. Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancer. Cancer Epidemiol Biomarkers Prev 2003; 12: 1429-1437.
11. Nam RK, Zhang WW, Klotz LH, Trachtenberg J, Jewett MAS, Sweet J et al. Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy. Clin Cancer Res 2006; 12: 6452-6458.
12. Province MA, Shannon WD, Rao DC. Classification methods for confronting heterogeneity. Adv Genet 2001; 74: 1302-1307.
13. Smith JR, Freije D, Carpten JD, Gronberg H, Xu J, Isaacs SD et al. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science 1996; 274: 1371-1374.
14. Cooney KA, McCarthy JD, Lange E, Huang L, Miesfeldt S, Montie JE et al. Prostate cancer susceptibility locus on chromosome 1q: A confirmatory study. J Natl Cancer Inst 1997; 89: 955-959.
15. Li H, Tai BC. RNASEL gene polymorphisms and the risk of prostate cancer: a meta-analysis. Clin Cancer Res 2006; 12: 5713-5719.
16. Carpten JD, Makalowska I, Robbins CM, Scott N, Sood R, Connors TD et al. A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region. Genomics 2000; 64: 1-14.
17. Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL et al. ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion. Mol endocrinol 2007; 21: 1835-1846.
18. Tomlins SA, Mehra R, Rhodes DR, Smith LR, Roulston D, Helgeson BE et al. TMPRSS2: ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res 2006; 66: 3396-3400.
19. Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, Wacholder S et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet 2007; 39: 645-649.
20. Gudmundsson J, Sulem P, Manolescu A, Amundadottir LT, Gudbjartsson D, Helgason A et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet 2007; 39: 631-637.
21. Haiman CA, Patterson N, Freedman ML, Myers SR, Pike MC, Waliszewska A et al. Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet 2007; 39: 638-644.