The development of a bioreactor to perfuse radially-confined hydrogel constructs: Design and characterization of mass transport properties

Biorheology

Volumn 46, Issue 5, 2009, Pages 417-437

  Eniwumide, Joshua O ^a   Lee, David A ^a   Bader, Dan L ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Bioreactors; Fluid flow; Molecular transport; Perfusion chondrocytes; Tissue engineering

Indexed keywords

AGAROSE; DEXTRAN;

ARTICLE; BIOREACTOR; CARTILAGE CELL; CELL VIABILITY; DIFFUSION; FLUID FLOW; HYDROGEL; TISSUE ENGINEERING;

ANIMALS; BIOLOGICAL TRANSPORT; BIOREACTORS; CARTILAGE, ARTICULAR; CATTLE; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHONDROCYTES; DEXTRANS; DIFFUSION; DNA; GLYCOSAMINOGLYCANS; HYDROGELS; MALE; PERFUSION; TISSUE ENGINEERING;

EID: 72949089953     PISSN: 0006355X     EISSN: None     Source Type: Journal    
DOI: 10.3233/BIR-2009-0552     Document Type: Article

References (48)

1. G.H. Altman, H.H. Lu, R.L. Horan et al., Advanced bioreactor with controlled application of multi-dimensional strain for tissue engineering, J. Biomech. Eng. 124 (2002), 742-749.
2. M.A. Anderson, J.T. Payne, J.M. Kreeger et al., Effects of intra-articular chlorhexidine diacetate lavage on the stifle in healthy dogs, Am. J. Vet. Res. 54 (1993), 1784-1789.
3. M. Brittberg, A. Lindahl, A. Nilsson et al., Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation, N. Engl. J. Med. 331 (1994), 889-895.
4. C.A. Chung, C.W. Yang and C.W. Chen, Analysis of cell growth and diffusion in a scaffold for cartilage tissue engineering, Biotech. Bioeng. 94 (2006), 1138-1146.
5. D.S. Clark, J.E. Bailey and D.D. Do, A mathematical-model for restricted diffusion effects on macromolecule impregnation in porous supports, Biotech. Bioeng. 27 (1985), 208-213.
6. T. Davisson, R.L. Sah and A. Ratcliffe, Perfusion increases cell content and matrix synthesis in chondrocyte threedimensional cultures, Tissue Eng. 8 (2002), 807-816.
7. O. Demarteau, M. Jakob, D. Schafer et al., Development and validation of a bioreactor for physical stimulation of engineered cartilage, Biorheology 40 (2003), 331-336.
8. S. Falsafi and R.J. Koch, Growth of tissue-engineered human nasoseptal cartilage in simulated microgravity, Arch. Otolaryngol. Head Neck Surg. 126 (2000), 759-765.
9. R.W. Farndale, C.A. Sayers and A.J. Barrett, A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures, Connect. Tissue Res. 9 (1982), 247-248.
10. S.J. Ferguson, K. Ito and L.P. Nolte, Fluid flow and convective transport of solutes within the intervertebral disc, J. Biomech. 37 (2004), 213-221.
11. L.E. Freed, A.P. Hollander, I. Martin et al., Chondrogenesis in a cell-polymer-bioreactor system, Exp. Cell Res. 240 (1998), 58-65.
12. L.E. Freed, J.C. Marquis, A. Nohria et al., Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers, J. Biomed. Mater. Res. 27 (1993), 11-23.
13. L.E. Freed, G. Vunjak-Novakovic, R.J. Biron et al., Biodegradable polymer scaffolds for tissue engineering, Biotechnology (NY), 12 (1994), 689-693.
14. G.K. Gorti, J. Lo, S. Falsafi et al., Cartilage tissue engineering using cryogenic chondrocytes, Arch. Otolaryngol. Head Neck Surg. 129 (2003), 889-893.
15. D.A. Grande, C. Halberstadt, G. Naughton et al., Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts, J. Biomed. Mater. Res. 34 (1997), 211-220.
16. J. Gutenwik, B. Nilsson and A. Axelsson, Effect of hindered diffusion on the adsorption of proteins in agarose gel using a pore model, J. Chromatogr. A 1048 (2004), 161-172.
17. H.K. Heywood, P.K. Sembi, D.A. Lee and D.L. Bader, Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs, Tissue Eng. 10 (2004), 1467-1479.
18. S. Holm, A. Maroudas, J.P. Urban et al., Nutrition of the intervertebral disc: Solute transport and metabolism, Connect. Tissue Res. 8 (1981), 101-119.
19. E.B. Hunziker, Biologic repair of articular cartilage. Defect models in experimental animals and matrix requirements, Clin. Orthop. Relat. Res. 367(Suppl.) (1999), S135-S146.
20. D.W. Hutmacher, Scaffolds in tissue engineering bone and cartilage, Biomaterials 21 (2000), 2529-2543.
21. S.L. Ishaug, G.M. Crane, M.J. Miller et al., Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds, J. Biomed. Mater. Res. 36 (1997), 17-28.
22. W. Kafienah, M. Jakob, O. Demarteau et al., Three-dimensional tissue engineering of hyaline cartilage: Comparison of adult nasal and articular chondrocytes, Tissue Eng. 8 (2002), 817-826.
23. Y.J. Kim, R.L. Sah, J.Y. Doong and A.J. Grodzinsky, Fluorometric assay of DNA in cartilage explants using Hoechst 33258, Anal. Biochem. 174 (1988), 168-176.
24. W. Kuhn, Concerning the shape of thread shapes molecules in solution, Kolloid-Zeitschrift 68 (1934), 2-15.
25. M.C. Lewis, B.D. Macarthur, J. Malda et al., Heterogeneous proliferation within engineered cartilaginous tissue: The role of oxygen tension, Biotech. Bioeng. 91 (2005), 607-615.
26. P.J. Livesley, M. Doherty, M. Needoff and A. Moulton, Arthroscopic lavage of osteoarthritic knees, J. Bone Joint Surg. Br. 73 (1991), 922-926.
27. A. Ljunglof and J. Thommes, Visualising intraparticle protein transport in porous adsorbents by confocal microscopy, J. Chromatogr. A 813 (1998), 387-395.
28. J. Malda, J. Rouwkema, D.E. Martens et al., Oxygen gradients in tissue-engineered PEGT/PBT cartilaginous constructs: Measurement and modeling, Biotech. Bioeng. 86 (2004), 9-18. (Pubitemid 38339386)
29. D. Marolt, A. Augst, L.E. Freed et al., Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors, Biomaterials 27 (2006), 6138-6149.
30. A. Maroudas, Transport of solutes through cartilage: Permeability to large molecules, J. Anat. 122 (1976), 335-347.
31. I. Martin, B. Obradovic, L.E. Freed and G. Vunjak-Novakovic, Method for quantitative analysis of glycosaminoglycan distribution in cultured natural and engineered cartilage, Ann. Biomed. Eng. 27 (1999), 656-662.
32. A.A. Neves, N. Medcalf and K. Brindle, Functional assessment of tissue-engineered meniscal cartilage by magnetic resonance imaging and spectroscopy, Tissue Eng. 9 (2003), 51-62.
33. D. Pazzano, K.A. Mercier, J.M. Moran et al., Comparison of chondrogensis in static and perfused bioreactor culture, Biotech. Progr. 16 (2000), 893-896.
34. N. Pernodet, M. Maaloum and B. Tinland, Pore size of agarose gels by atomic force microscopy, Electrophoresis 18 (1997), 55-58.
35. A. Pluen, P.A. Netti, R.K. Jain and D.A. Berk, Diffusion of macromolecules in agarose gels: Comparison of linear and globular configurations, Biophys. J. 77 (1999), 542-552.
36. M. Steinwachs and P.C. Kreuz, Autologous chondrocyte implantation in chondral defects of the knee with a type I/III collagen membrane: A prospective study with a 3-year follow-up, Arthroscopy 23 (2007), 381-387.
37. K.R. Stone, A.W. Walgenbach, A. Freyer et al., Articular cartilage paste grafting to full-thickness articular cartilage knee joint lesions: A 2-to 12-year follow-up, Arthroscopy 22 (2006), 291-299.
38. P. Sucosky, D.F. Osorio, J.B. Brown and G.P. Neitzel, Fluid mechanics of a spinner-flask bioreactor, Biotech. Bioeng. 85 (2004), 34-46.
39. R. Sutherland, J. Freyer, W. Mueller-Klieser et al., Cellular growth and metabolic adaptations to nutrient stress environments in tumor microregions, Int. J. Radiat. Oncol. Biol. Phys. 12 (1986), 611-615.
40. T. Tallheden, C. Bengtsson, C. Brantsing et al., Proliferation and differentiation potential of chondrocytes from osteoarthritic patients, Arthritis Res. Ther. 7 (2005), R560-R568.
41. S.R. Tew, A.P. Kwan, A. Hann et al., The reactions of articular cartilage to experimental wounding: Role of apoptosis, Arthritis Rheum. 43 (2000), 215-225.
42. B.R. Unsworth and P.I. Lelkes, Growing tissues in microgravity, Nat. Med. 4 (1998), 901-907.
43. J.P. Urban, S. Holm, A. Maroudas and A. Nachemson, Nutrition of the intervertebral disk. An in vivo study of solute transport, Clin. Orthop. Relat. Res. 129 (1977), 101-114.
44. J.P. Urban, S. Holm, A. Maroudas and A. Nachemson, Nutrition of the intervertebral disc: Effect of fluid flow on solute transport, Clin. Orthop. Relat. Res. 170 (1982), 296-302.
45. N. Veilleux and M. Spector, Effects of FGF-2 and IGF-1 on adult canine articular chondrocytes in type II collagenglycosaminoglycan scaffolds in vitro, Osteoarthr. Cartil. 13 (2005), 278-286.
46. G. Vunjak-Novakovic, I. Martin, B. Obradovic et al., Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage, J. Orthop. Res. 17 (1999), 130-138.
47. D. Wendt, A. Marsano, M. Jakob et al., Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity, Biotech. Bioeng. 84 (2003), 205-214.
48. X. Xu, J.P. Urban, U. Tirlapur et al., Influence of perfusion on metabolism and matrix production by bovine articular chondrocytes in hydrogel scaffolds, Biotech. Bioeng. 93 (2006), 1103-1111.