Reference intervals for serum testosterone, SHBG, LH and FSH in males from the NORIP project

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 69, Issue 8, 2009, Pages 873-879

  Bjerner, Johan ^a   Biernat, Donata ^b   Fosså, Sophie D ^c   Bjøro, Trine ^d  

^a LINKÖPING UNIVERSITY   (Sweden)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Endocrinology; Fertility hormones; Hormones; Reference levels

Indexed keywords

ALBUMIN; ANDROGEN; FOLLITROPIN; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGED; ANDROGEN BLOOD LEVEL; ARTICLE; CALCULATION; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MALE; PRIORITY JOURNAL; REFERENCE VALUE; STATISTICAL SIGNIFICANCE; TESTOSTERONE BLOOD LEVEL;

ADULT; AGED; CASE-CONTROL STUDIES; CONFIDENCE INTERVALS; FOLLICLE STIMULATING HORMONE; HUMANS; LUTEINIZING HORMONE; MALE; MIDDLE AGED; RECEPTORS, CELL SURFACE; REFERENCE VALUES; REGRESSION ANALYSIS; TESTOSTERONE;

EID: 72749102518     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365510903380886     Document Type: Article

References (39)

1. Schaap LA, Pluijm SM, Deeg DJ, Penninx BW, Nicklas BJ, Lips P, Harris TB, Newman AB, Kritchevsky SB, Cauley JA, Goodpaster BH,Tylavsky FA,Yaffe K,Visser M; Health ABC study. Low testosterone levels and decline in physical performance and muscle strength in older men: Findings from two prospective cohort studies. Clin Endocrinol (Oxf) 2008;68:42-50.
2. Amin S, Zhang Y, Felson DT, Sawin CT, Hannan MT, Wilson PW, Kiel DP. Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study. Am J Med 2006;119:426-433
3. Meier C, Nguyen TV, Handelsman DJ, Schindler C, Kushnir MM, Rockwood AL, , Meikle AW, Center JR, Eisman JA, Seibel MJ. Endogenous sex hormones and incident fracture risk in older men: The Dubbo Osteoporosis Epidemiology Study. Arch Intern Med 2008;168:47-54.
4. Almeida OP, Waterreus A, Spry N, Flicker L, Martins RN. One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men. Psychoneuroendocrinology 2004;29: 1071-1081
5. Ajayi AA, Mathur R, Halushka PV. Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation 1995;91:2742-2747
6. Coviello AD, Kaplan B, Lakshman KM, Chen T, Singh AB, Bhasin S. Effects of graded doses of testosterone on erythropoiesis in healthy young and older men. J Clin Endocrinol Metab 2008;93:914-919
7. Laaksonen DE, Niskanen L, Punnonen K, Nyyssönen K, Tuomainen TP, Valkonen VP, Salonen R, Salonen JT. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004;27:1036-1041
8. Dhindsa S, Prabhakar S, Sethi M, Bandyopadhyay A, Chaudhuri A, Dandona P. Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. J Clin Endocrinol Metab 2004;89:5462-5468
9. Albrecht-Betancourt M, Hijazi RA, Cunningham GR. Androgen replacement in men with hypogonadism and erectile dysfunction. Endocrine 2004;23:143-148
10. Reyes-Vallejo L, Lazarou S, Morgentaler A. Subjective sexual response to testosterone replacement therapy based on initial serum levels of total testosterone. J Sex Med 2007;4:1757-1762
11. Emmelot-Vonk MH, Verhaar HJ, Nakhai Pour HR, Aleman A, Lock TM, Bosch JL, Grobbee DE, van der Schouw YT. Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: A randomized controlled trial. JAMA 2008;299:39-52.
12. Emmelot-Vonk MH, Verhaar HJ, Nakhai-Pour HR, Grobbee DE, van der Schouw YT. Effect of testosterone supplementation on sexual functioning in aging men: A 6-month randomized controlled trial. Int J Impot Res 2009;21:129-138
13. Nakhai-Pour HR, Grobbee DE, Emmelot-Vonk MH, Bots ML, Verhaar HJ, van der Schouw YT. Oral testosterone supplementation and chronic low-grade inflammation in elderly men: A 26-week randomized, placebo-controlled trial. Am Heart J 2007;154:1228.e1-7
14. Nair KS, Rizza RA, O'Brien P, Dhatariya K, Short KR, Nehra A, Vittone JL, Klee GG, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall DJ, Melton LJ 3rd, Smith GE, Khosla S, Jensen MD. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med 2006; 355:1647-1659
15. Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, Bremner WJ, McKinlay JB. Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 2002;87:589-598
16. Vermeulen A, Verdonck L, Kaufman JM. Acritical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84: 3666-3672
17. Ho CK, Stoddart M, Walton M, Anderson RA, Beckett GJ. Calculated free testosterone in men: Comparison of four equations and with free androgen index. Ann Clin Biochem 2006;43:389-397
18. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR, Aging BLSO. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001;86:724-731
19. Mohr BA, Guay AT, O'Donnell AB, McKinlay JB. Normal, bound and nonbound testosterone levels in normally ageing men: Results from the Massachusetts Male Ageing Study. Clin Endocrinol (Oxf) 2005;62:64-73.
20. Svartberg J, Midtby M, Bønaa KH, Sundsfjord J, Joakimsen RM, Jorde R. The associations of age, lifestyle factors and chronic disease with testosterone in men: The Tromsø Study. Eur J Endocrinol 2003;149:145-152
21. Svartberg J, Jorde R. Endogenous testosterone levels and smoking in men. The fifth Tromsø study. Int J Androl 2007;30:137-143
22. Sparrow D, Bosse R, Rowe JW. The influence of age, alcohol consumption, and body build on gonadal function in men. J Clin Endocrinol Metab 1980;51:508-512
23. Litman HJ, Bhasin S, Link CL, Araujo AB, McKinlay JB. Serum androgen levels in black, Hispanic, and white men. J Clin Endocrinol Metab 2006;91:4326-4334
24. Resko JA, Eik-nes KB. Diurnal testosterone levels in peripheral plasma of human male subjects. J Clin Endocrinol Metab 1966;26:573-576
25. Svartberg J, Jorde R, Sundsfjord J, Bønaa KH, Barrett- Connor E. Seasonal variation of testosterone and waist to hip ratio in men: The Tromsø study. J Clin Endocrinol Metab 2003;88:3099-3104
26. Kaku H, Saika T, Tsushima T, Ebara S, Senoh T, Yamato T, Nasu Y, Kumon H. Time course of serum testosterone and luteinizing hormone levels after cessation of long-term luteinizing hormone-releasing hormone agonist treatment in patients with prostate cancer. Prostate 2006;66:439-444
27. Wang C, Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, Gooren LJ, Kaufman JM, Legros JJ, Lunenfeld B, Morales A, Morley JE, Schulman C, Thompson IM, Weidner W, Wu FC. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol 2008;159:507-514
28. Arver S, Lehtihet M. Current guidelines for the diagnosis of testosterone deficiency. Front Horm Res 2009;37: 5-20.
29. Bhasin S, Zhang A, Coviello A, Jasuja R, Ulloor J, Singh R, Vesper H, Vasan RS. The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders. Steroids 2008;73:1311-1317
30. Rustad P, Simonsson P, Felding P, Pedersen M. Nordic Reference Interval Project Bio-bank and Database (NOBIDA): A source for future estimation and retrospective evaluation of reference intervals. Scand J Clin Lab Invest 2004 ;64:431-438
31. Felding P, Rustad P, Mårtensson A, Kairisto V, Franzson L, Hyltoft Petersen P, Uldall A. Reference individuals, blood collection, treatment of samples and descriptive data from the questionnaire in the Nordic Reference Interval Project 2000. Scand J Clin Lab Invest 2004;64: 327-342 (Pubitemid 38918103)
32. Pedersen MM, Rustad P, Simonsson P. Certificate of analysis NFKK Reference Serum X: A reprint. Scand J Clin Lab Invest 2004;64:321-326
33. Carter GD, Holland SM, Alaghband-Zadeh J, Rayman G, Dorrington-Ward P, Wise PH. Investigation of hirsutism: Testosterone is not enough. Ann Clin Biochem 1983;20 (Pt 5):262-263
34. Nanjee MN, Wheeler MJ. Plama free testosterone - is an index sufficient? Ann Clin Biochem 1985;22 (Pt 4): 387-390
35. Wright EM, Royston P. Calculating reference intervals for laboratory measurements. Stat Methods Med Res 1999;8: 93-112.
36. Royston P, Altman DG, Sauerbrei W. Dichotomizing continuous predictors in multiple regression: A bad idea. Stat Med 2006;25:127-141
37. Bjerner J. Age-dependent biochemical quantities: An approach for calculating reference intervals. Scand J Clin Lab Invest 2007;67:707-722
38. Bjerner J, Høgetveit A, Wold Akselberg K, Vangsnes K, Paus E, Bjøro T, Børmer OP, Nustad K. Reference intervals for carcinoembryonic antigen (CEA), CA125, MUC1, Alfa- foeto-protein (AFP), neuron-specific enolase (NSE) and CA19.9 from the NORIP study. Scand J Clin Lab Invest 2008;68:703-713
39. Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005;26:833-876