The algal hepatoxoxin okadaic acid is a substrate for human cytochromes CYP3A4 and CYP3A5

Toxicon

Volumn 55, Issue 2-3, 2010, Pages 325-332

  Guo, Fujiang ^a   An, Tianying ^a   Rein, Kathleen S ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

Cytochrome P450; Diarrheic shellfish poisoning (DSP); Human liver microsome; Metabolism; Okadaic acid; Protein phosphatase inhibitors

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; HYDROXYL GROUP; KETOCONAZOLE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A;

ALGA; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; ENZYME METABOLISM; HUMAN; HUMAN CELL; HYDROXYLATION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME METABOLISM; MASS SPECTROMETRY; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL; PROTEIN FAMILY;

BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; CYTOCHROME P-450 CYP3A; DRUG-INDUCED LIVER INJURY; ENZYME INHIBITORS; HUMANS; KINETICS; LIVER; MASS SPECTROMETRY; MICROSOMES, LIVER; OKADAIC ACID; OXIDATION-REDUCTION; PROTEIN PHOSPHATASE 2; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; XENOBIOTICS;

ALGAE;

EID: 72749099019     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.08.007     Document Type: Article

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