A protein phosphatase 2A inhibition assay for a fast and sensitive assessment of okadaic acid contamination in mussels

Toxicon

Volumn 34, Issue 7, 1996, Pages 743-752

  Tubaro, Aurelia ^a   Florio, Chiara ^a   Luxich, Elena ^a   Sosa, Silvio ^a   Della Loggia, Roberto ^a   Yasumoto, Takeshi ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE;

ANIMAL TISSUE; ARTICLE; BIOASSAY; CYTOTOXICITY; DOSE RESPONSE; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOCRINE GLAND; FOOD CONTAMINATION; MUSSEL; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0030200158     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/0041-0101(96)00027-X     Document Type: Article

References (23)

1. Aune T. and Yndestad M. (1993) Diarrhetic Shellfish Poisonining. In: Algal Toxins in Seafood and Drinking Water, pp. 87-104 (Falconer I. R., Ed.). London: Academic Press.
2. Bialojan C. and Takai A. (1988) Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem. J. 256, 283-290.
3. Boland M. P., Smillie M. A., Chen D. Z. X. and Holmes C. F. B. (1993) A unified bioscreen for the detection of diarrhetic shellfish toxins and microcystins in marine and freshwater environments. Toxicon 31, 1393-1405.
4. Chen D. Z. X. Jr, Boland M. P., Smillie M. A., Klix H., Ptak C., Andersen R. J. and Holmes C. F. B. (1993) Identification of protein phosphatase inhibitors of the microcystin class in the marine environment. Toxicon 31, 1407-1414.
5. Cohen P. (1989) The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58, 453-508.
6. Della Loggia R., Cabrini M., Del Negro P., Honsell G. and Tubaro A. (1993) Relationship between Dinophysis spp. in seawater and DSP toxins in mussels in the Northern Adriatic Sea. Der. Mar. Biol. 3, 483-488.
7. Falconer I. R., Dornbusch M., Moran G. and Yeung K. (1992) Effect of the cyanobacterial (blue-green algal) toxins from Microcystis aeruginosa on isolated enterocytes from the chicken small intestine. Toxicon 30, 790-793.
8. Fujiki H., Suganuma M., Hishiwaki S., Yoshizawa S., Yatsunami J., Matsushima R., Furuya H., Okabe S., Matsunaga S. and Sugimura T. (1992) Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway. Prog. Clin. Biol. Res. 374, 337-350.
9. Fujiki H. and Suganuma M. (1993) Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds. Adv. Cancer Res. 61, 143-194.
10. Hallegraff G. M. (1993) A review of harmful algal blooms and their apparent global increase. Phycol. 32, 79-99.
11. Holmes C. F. B. (1991) Liquid chromatography-linked protein phosphatase bioassay. A highly sensitive marine bioscreen for okadaic acid and related diarrhetic shellfish toxins. Toxicon 29, 469-477.
12. Luu H. A., Chen D. Z. X., Magoon J., Worms J., Smith J. and Holmes C. F. B. (1993) Quantification of diarrhetic shellfish toxins and identification of novel protein phosphatase inhibitors in marine phytoplankton and mussels. Toxicon 31, 75-83.
13. Luxich E., Florio C., Della Loggia R., Vertua R., Tubaro A. and Yasumoto T. (1995) A cytotoxicity assay to detect the DSP contamination of mussels. Seventh International Conference on Toxic Phytoplankton. 12-16 July 1995 (Abstract). Sendai (Japan).
14. Pillet S., Pereira A., Breakman J.-C. and Houvenaghel G. (1995) Patterns in long term accumulation of okadaic acid and DTX1 in blue mussels. Mytilus edulis, experimentally fed with the DSP-containing alga Prorocentrum lima. In: Harmful Marine Algal Blooms, pp. 487-492 (Lassus P., Arzul G., Erard-Le Denn E., Gentien P. and Marcaillou-Le Baut, C., Eds). Paris: Lavoisier Publishing.
15. Simon J. F. and Vernoux J.-P. (1994) Highly sensitive assay of okadaic acid using protein phosphatase and paranitrophenyl phosphate. Nat. Toxins 2, 293-301.
16. Takai A. and Mieskes G. (1991) Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases. Biochem. J. 275, 233-239.
17. Takai A., Sasaki K., Nagai H., Mieskes G., Isobe M., Isono K. and Yasumoto T. (1995) Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein. Biochem. J. 306, 657-665.
18. Tubaro A., Sosa S., Bussani D., Sidari L., Honsell G. and Della Loggia R. (1995) Diarrhoeic toxicity induction in mussels of the gulf of Trieste. In: Harmful Marine Algal Blooms, pp. 249-254 (Lassus P., Arzul G., Erard-Le Denn E., Gentien P. and Marcaillou-Le Baut C., Eds). Paris: Lavoisier Publishing.
19. Van Egmond H. P., Aune T., Lassus P., Speijers G. J. A. and Waldock M. (1993) Paralytic and diarrhoeic shellfish poisons: occurrence in Europe, toxicity, analysis and regulation. J. Nat Toxins 2, 41-83.
20. Yasumoto T., Oshima Y. and Yamaguchi M. (1978) Occurrence of a new type of shellfish poisoning in the Tohoku District. Bull. Jpn. Soc. Sci. Fish. 44, 1249-1255.
21. Yasumoto T., Murata M., Lee J.-S. and Torigoe K. (1989) Polyether toxins produced by dinoflagellates. In: Mycotoxins and Phycotoxins '88, pp. 375-382 (Natori S., Hashimoto K. and Ueno Y., Eds). Amsterdam: Elsevier Science Publishers B.V.
22. Yasumoto T. (1990) Diarrhetic shellfish poisoning and okadaic acid. Jikken Igaku 8, 1243-1247.
23. Yasumoto T. and Murata M. (1993). Marine toxins. Chem. Rev. 93, 1897-1909.