Identification and characterization of DTX-5c and 7-hydroxymethyl-2-methylene-octa-4,7-dienyl okadaate from Prorocentrum belizeanum cultures by LC-MS

Toxicon

Volumn 50, Issue 4, 2007, Pages 470-478

  Paz, Beatriz ^b   Daranas, Antonio H ^a   Cruz, Patricia G ^a   Franco, José M ^b   Napolitano, José G ^a   Norte, Manuel ^a   Fernández, José J ^a  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

^b INSTITUTO DE INVESTIGACIONES MARINAS   (Spain)

Author keywords

DSP; LC MS; Marine toxins; OA derivatives; Prorocentrum belizeanum

Indexed keywords

7 HYDROXYMETHYL 2 METHYLENE OCTA 4,7 DIENYL OKADAATE; DINOPHYSISTOXIN 1; DINOPHYSISTOXIN 5C; MARINE TOXIN; UNCLASSIFIED DRUG;

ARTICLE; CULTURE MEDIUM; DINOFLAGELLATE; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROROCENTRUM BELIZEANUM; TOXIN ANALYSIS; TOXIN STRUCTURE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DINOFLAGELLIDA; MARINE TOXINS; MASS SPECTROMETRY; OKADAIC ACID;

DINOPHYCEAE; PROROCENTRUM BELIZEANUM;

EID: 34548463860     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2007.04.011     Document Type: Article

References (14)

1. Cruz P.G., Daranas A.H., Fernández J.J., Souto M.L., and Norte M. DTX5c, a new OA sulphate ester derivative from cultures of Prorocentrum belizeanum. Toxicon 47 (2006) 920-924
2. Daranas A.D., Norte M., and Fernández J.J. Toxic marine migroalgae. Toxicon 39 (2001) 1101-1132
3. Fernández M.L., Richard D.J.A., and Cembella A.D. In vivo assays for phycotoxin. In: Hallegraeff G.M., Andereson D.M., and Cembella A.D. (Eds). Manual on Harmful Marine Microalgae. Monographs on Oceanographic Methodology (2003), UNESCO, Paris 347-380
4. Hu T., Curtis J.M., Walter J.A., and Wright J.L.C. Identification of DTX-4, a new water-soluble phosphatase inhibitor from the toxic dinoflagellate Prorocentrum lima. J. Chem. Soc. Chem. Commun. 597 (1995)
5. Hu T., Curtis J.M., Walter J.A., McLachlanb J.L., and Wright L.C. Two new water-soluble DSP toxin derivatives from the Dinoflagellate Prorocentrum maculosum: possible Storage and excretion products. Tetrahedron Lett. 36 (1995) 9273-9276
6. 18O in dinoflagellate Prorocentrum lima elucidated by tandem mass spectrometry. FEBS Eur. J. Biochem. 267 (2000) 5179-5183
7. Keller M.D., Selvin R.C., Claus W., and Guillard R.R.L. Media for the culture of oceanic ultraphytoplankton. J. Phycol. 23 (1987) 633-638
8. 2]acetate elucidated by collision-induced dissociation tandem mass spectrometry. J. Am. Chem. Soc. 120 (1998) 147-151
9. Quilliam M.A. Analysis of diarrhetic shellfish poisoning toxins in shellfish tissue by LC with fluorometric and mass spectrometric detection. J. AOAC Int. 78 (1995) 555-569
10. Quilliam M.A., and Ross N.W. Analysis of diarrhetic shellfish poisoning toxins and metabolites in plankton and shellfish by liquid chromatography-ionspray mass spectrometry. In: Snyder A.P. (Ed). Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry, ACS Symposium Series 619 (1996), American Chemical Society, Anaheim, CA, Washington, DC 351-364
11. Quilliam M.A. Chemical methods for liphophilic shellfish toxin. In: Hallegraeff G.M., Anderson D.M., and Cembella A.D. (Eds). Manual on Harmful Marine Microalgae. Monographs on Oceanographic Methodology (2003), UNESCO, Paris 297-345
12. Quilliam, M.A., Hardstaff, W.R., Ishida, N., McLachlan, J.L., Reeves, A.R., Ross, N.W., Windust, A.J., 1996. Production of Diarrhetic Shellfish Poisoning (DSP) Toxins by Prorocentrum lima in Culture and Development of Analytical Methods. Intergovernmental Oceanographic Commission of UNESCO, Sendai, Japan, pp. 289-292.
13. Suárez-Gómez B., Souto M.L., Cruz P.G., Fernández J.J., and Norte M. New targets in diarrhetic shellfish poisoning control. J. Nat. Prod. 68 (2005) 596-599
14. Suzuki T., Beuzenberg V., Mackenzie L., and Quilliam M.A. Discovery of okadaic acid esters in the toxic dinoflagellate Dinophysis acuta from New Zealand using liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 18 (2004) 1131-1138