Anti-inflammatory and Analgesic Effects of Elephantopus tomentosus Ethanolic Extract

JAMS Journal of Acupuncture and Meridian Studies

Volumn 2, Issue 4, 2009, Pages 280-287

  Yam, Mun Fei ^a,b   Ang, Lee Fung ^a   Ameer, Omar Ziad ^a   Salman, Ibrahim Muhammad ^a   Aziz, Hesham Abdul ^a   Asmawi, Mohd Zaini ^a  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

analgesic effect; anti inflammatory; Elephantopus tomentosus

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CARRAGEENAN; ELEPHANTOPUS TOMENTOSUS EXTRACT; INDOMETACIN; MORPHINE; PARACETAMOL; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CAPILLARY PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; ELEPHANTOPUS TOMENTOSUS; FEMALE; HOT PLATE TEST; HYPERALGESIA; MALE; MEDICINAL PLANT; NONHUMAN; PAIN THRESHOLD; PAW EDEMA; PHYTOCHEMISTRY; PRIORITY JOURNAL; RAT; RESPONSE TIME; TAIL FLICK TEST; TREATMENT OUTCOME; WRITHING TEST; ANIMAL; ASTERACEAE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; EDEMA; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; MOUSE; PAIN; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTERACEAE; DISEASE MODELS, ANIMAL; EDEMA; FEMALE; HUMANS; MALE; MICE; MICE, INBRED ICR; PAIN; PAIN THRESHOLD; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 72649100137     PISSN: 20052901     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2005-2901(09)60069-8     Document Type: Article

References (38)

1. Sosa S., Balick M.J., Arvigo R., Esposito R.G., Pizza C., Altinier G., et al. Screening of the topical anti-inflammatory activity of some Central American plants. J Ethnopharmacol 81 (2002) 211-215
2. Yam M.F., Asmawi M.Z., and Basir R. An investigation of the antiinflammatory and analgesic effects of Orthosiphon stamineus leaf extract. J Med Food 11 (2008) 362-368
3. Andrade S.F., Lemos M., Comunello E., Noldin V.F., Filho V.C., and Niero R. Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models. J Ethnopharmacol 113 (2007) 252-257
4. Gooch K., Culleton B.F., Manns B.J., Zhang J., Alfonso H., Tonelli M., et al. NSAID use and progression of chronic kidney disease. Am J Med 120 (2007) 280e1-280e7
5. Jaganath I.B., and Ng L.T. Herbs the green pharmacy of Malaysia (2000), Vinpress, Kuala Lumpur 76-77
6. Yam M.F., Basir R., Asmawi M.Z., Rosdiah, Ahmad M., and Akowuah G.A. Antioxidant and hepatoprotective activities of Elephantopus tomentosus ethanol extract. Pharm Biol 46 (2008) 199-206
7. Winter C.A., Risley E.A., and Nus G.V. Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drug. Proc Soc Exp Biol Med 111 (1962) 544-547
8. Whittle B.A. The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics. Br J Pharmacol Chemother 22 (1964) 246-253
9. Winter C.A., and Flataker L. Nociceptive thresholds as affected by parenteral administration of irritants and of various antinociceptive drugs. J Pharmacol Exp Ther 148 (1965) 373-379
10. Iwalewa E.O., Iwalewa O.J., and Adeboye J.O. Analgesic, antipyretic, anti-inflammatory effects of methanol, chloroform and ether extracts of Vernonia cinerea less leaf. J Ethnopharmacol 86 (2003) 229-234
11. Koster R., Anderson M., and DeBeer E.J. Acetic acid for analgesic screening. Fed Proc 18 (1959) 412
12. Harborne J.B. Phytochemical methods: A guide to modern techniques of plant Analysis (1973), Chapman & Hall, London 279
13. Awe I.S., and Sodipo O.A. Purification of saponins of root of Bhlighiasapida Koenig-Holl. Nig J Biochem Mol Biol 16 (2001) s2014
14. Sofowora A. Medicinal Plants and Traditional Medicine in Africa. 2nd ed. (1993), Spectrum Books Ltd, Nigeria 134-156
15. Odebiyi A., and Sofowora A.E. Phytochemical screening of Nigerian medicinal plants (III). Lloydia 41 (1978) 234-246
16. Owoyele O.V., Adebukola O.M., Funmilayo A.A., and Soladoye O.A. Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharm 16 (2008) 168-173
17. Trease G.E., and Evans W.C. A textbook of Pharmacognosy. 13th ed. (1989), Bailliere-Tyndall Ltd., London
18. Brito A., and Antonio M.A. Oral anti-inflammatory and antiulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae). J Ethnopharmacol 61 (1998) 215-228
19. Di Rosa M. Review. Biological properties of carrageenan. J Pharm Pharmacol 24 (1972) 89-102
20. Di Rosa M., Giroud J.P., and Willoughby D.A. Studies of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J Pathol 104 (1971) 15-29
21. Crunkhon P., and Meacock S. Mediators of the inflammation induced in the rat paw by carrageenan. Brit J Pharmacol 42 (1971) 392-402
22. Mossa J.S., Rafatullah S., Galai A.M., and Al-Yahya M.A. Pharmacological studies of Rhus retinorrhaea. Int J Pharmacog 33 (1995) 242-246
23. Kang H.S., Lee J.Y., and Kim C.J. Anti-inflammatory activity of arctigenin from Forsythiae Fructus. J Ethnopharm 116 (2008) 305-311
24. Prado W.A., Tonussi C.R., Rego E.M., and Corrado A.P. Antinociception induced by intraperitoneal injection of gentamicin in rats and mice. Pain 4 (1990) 365-371
25. Gupta M., Mazumder U.K., Kumar R.S., Gomathi P., Rajeshwar Y., Kakoti B.B., et al. Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models. J Ethnopharmacol 98 (2005) 267-273
26. Ferreira S.H., and Vane S.R. New aspects on the mode of action of non-steroid anti-inflammatory drugs. Ann Rev Pharmacol 14 (1974) 57-73
27. Perianayagam J.B., Sharma S.K., Joseph A., and Christina A. Evaluation of anti-pyretic and analgesic activity of Emblica officinalis Gaertn. J Ethnopharmacol 95 (2004) 83-85
28. Ferreira S.H. Prostaglandins. Chemical messengers of the inflammatory process (1979), Elsevier/North-Holland Biomedical Press, Amsterdam 113-151
29. Bars D., Gozariu M., and Cadden S.W. Animals models of nociception. Pharmacol Rev 53 (2001) 597-652
30. Koo H.J., Lim K.H., Jung H.J., and Park E.H. Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J Ethnopharmacol 103 (2006) 496-500
31. Hokanson G.C. Acetic acid for analgesic screening. J Nat Prod 41 (1978) 497-498
32. Duarte J.D.G., Nakamura M., and Ferreira S.H. Participation of the sympathetic system in acetic acid induced writhing in mice. Braz J Med Biol Res 21 (1988) 341-343
33. Garcia-Leme J., Nakamura L., Leite M.P., and Rochae Silva M. Pharmacological analysis of the acute inflammation process induced in rat's paw by local injection of carrageenan and heating. Brit J Pharmacol 64 (1973) 91-98
34. Hosseinzadeh H., and Younesi H.M. Antinociceptive and antiinflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol 2 (2002) 7-16
35. Wang J.R., Zhou H., Jiang Z.H., Wong Y.F., and Liu L. In vivo antiinflammatory and analgesic activities of a purified saponin fraction derived from the root of Ilex pubescens. Biol Pharm Bull 31 (2008) 643-650
36. Thirugnanasambantham P., Viswanathan S., Ramaswamy S., Krishnamurty V., Mythirayee C., and Kameswaran L. Analgesic activity of certain flavone derivatives: a structure-activity study. Clinical Exp Pharm Physiol 20 (2007) 59-63
37. Viana G.S.B., Bandeira M., Moura L.C., Souza-Filho M.V.P., Matos F., and Ribeiro R.A. Analgesic and antiinflammatory effects of the tannin fraction from Myracrodruon urundeuva Fr. All. Phytother Res 11 (1998) 118-122
38. Loomis T.A., and Hayes A.W. Loomis's Essentials of Toxicology (1996), Academic Press, CA