Divergent effects of norepinephrine, dopamine and substance P on the activation, differentiation and effector functions of human cytotoxic T lymphocytes

BMC Immunology

Volumn 10, Issue , 2009, Pages

  Strell, Carina ^a   Sievers, Anne ^a   Bastian, Philipp ^a   Lang, Kerstin ^a   Niggemann, Bernd ^a   Zänker, Kurt S ^a   Entschladen, Frank ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; CD28 ANTIGEN; CD3 ANTIGEN; CHEMOKINE RECEPTOR CXCR1; DOPAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NORADRENALIN; SUBSTANCE P;

ARTICLE; CD8+ T LYMPHOCYTE; CELL ADHESION; CELL INTERACTION; CONTROLLED STUDY; CROSS LINKING; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DOWN REGULATION; ENZYME INHIBITION; EXTRAVASATION; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL CULTURE; CELL DIFFERENTIATION; CELL MOTION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; IMMUNOLOGY; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

CELL ADHESION; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; DOPAMINE; ENDOTHELIUM, VASCULAR; HUMANS; INTERLEUKIN-2; INTERLEUKIN-8; LYMPHOCYTE ACTIVATION; MAP KINASE SIGNALING SYSTEM; NEUROIMMUNOMODULATION; NF-KAPPA B; NOREPINEPHRINE; SUBSTANCE P; T-LYMPHOCYTES, CYTOTOXIC;

EID: 72549105694     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-10-62     Document Type: Article

References (53)

1. Felten DL. Direct innervation of lymphoid organs: substrate for neurotransmitter signaling of cells of the immune system. Neuropsychobiol 1993, 28:110-2.
2. Fink T, Weihe E. Multiple neuropeptides in nerves supplying mammalian lymph nodes: messenger candidates for sensory and autonomic neuroimmunomodulation?. Neurosci Lett 1988, 90:39-44. 10.1016/0304-3940(88)90783-5, 2457855.
3. Lang K, Bastian P. Neurotransmitter effects on tumor cells and leukocytes. Prog Exp Tumor Res 2007, 39:99-121. full_text, 17314504.
4. Sloan EK, Capitanio JP, Cole SW. Stress-induced remodeling of lymphoid innervation. Brain Behav Immun 2008, 22:15-21. 10.1016/j.bbi.2007.06.011, 2754291, 17697764.
5. Kin NW, Sanders VM. It takes nerve to tell T and B cells what to do. J Leukoc Biol 2006, 79:1093-104. 10.1189/jlb.1105625, 16531560.
6. Lucin KM, Sanders VM, Jones TB, Malarkey WB, Popovich PG. Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation. Exp Neurol 2007, 207:75-84. 10.1016/j.expneurol.2007.05.019, 2023967, 17597612.
7. Kohm AP, Sanders VM. Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo. Pharmacol Rev 2001, 53:487-525.
8. Grebe KM, Hickman HD, Irvine KR, Takeda K, Bennink JR, Yewdell JW. Sympathetic nervous system control of anti-influenza CD8+ T cell responses. Proc Natl Acad Sci USA 2009, 106:5300-5. 10.1073/pnas.0808851106, 2664017, 19286971.
9. Weihe E, Nohr D, Michel S, Muller S, Zentel HJ, Fink T, Krekel J. Molecular anatomy of the neuro-immune connection. Int J Neurosci 1991, 59:1-23. 10.3109/00207459108985446, 1774130.
10. Barili P, Bronzetti E, Felici L, Ferrante F, Ricci A, Zaccheo D, Amenta F. Age-dependent changes in the expression of dopamine receptor subtypes in human peripheral blood lymphocytes. J Neuroimmunol 1996, 71:45-50. 10.1016/S0165-5728(96)00127-0, 8982102.
11. Levite M, Chowers Y, Ganor Y, Besser M, Hershkovits R, Cahalon L. Dopamine interacts directly with its D3 and D2 receptors on normal human T cells, and activates beta1 integrin function. Eur J Immunol 2001, 31:3504-12. 10.1002/1521-4141(200112)31:12<3504::AID-IMMU3504>3.0.CO;2-F, 11745370.
12. Watanabe Y, Nakayama T, Nagakubo D, Hieshima K, Jin Z, Katou F, Hashimoto K, Yoshie O. Dopamine selectively induces migration and homing of naive CD8+ T cells via dopamine receptor D3. J Immunol 2006, 176:848-56.
13. Nakano K, Higashi T, Hashimoto K, Takagi R, Tanaka Y, Matsushita S. Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis. Biochem Biophys Res Commun 2008, 373:286-91. 10.1016/j.bbrc.2008.06.012, 18558081.
14. Hasko G, Szabo C, Nemeth ZH, Deitch EA. Dopamine suppresses IL-12 p40 production by lipopolysaccharide-stimulated macrophages via a beta-adrenoceptor-mediated mechanism. J Neuroimmunol 2002, 122:34-9. 10.1016/S0165-5728(01)00459-3, 11777541.
15. Saha B, Mondal AC, Majumder J, Basu S, Dasgupta PS. Physiological concentrations of dopamine inhibit the proliferation and cytotoxicity of human CD4+ and CD8+ T cells in vitro: a receptor-mediated mechanism. Neuroimmunomodulation 2001, 9:23-33. 10.1159/000049004, 11435749.
16. Torres KC, Antonelli LR, Souza AL, Teixeira MM, Dutra WO, Gollob KJ. Norepinephrine, dopamine and dexamethasone modulate discrete leukocyte subpopulations and cytokine profiles from human PBMC. J Neuroimmunol 2005, 166:144-57. 10.1016/j.jneuroim.2005.06.006, 16026859.
17. Ghosh MC, Mondal AC, Basu S, Banerjee S, Majumder J, Bhattacharya D, Dasgupta PS. Dopamine inhibits cytokine release and expression of tyrosine kinases, Lck and Fyn in activated T cells. Int Immunopharmacol 2003, 3:1019-26. 10.1016/S1567-5769(03)00100-0, 12810359.
18. Herpfer I, Lieb K. Substance P receptor antagonists in psychiatry: rationale for development and therapeutic potential. CNS Drugs 2005, 19:275-93. 10.2165/00023210-200519040-00001, 15813642.
19. Tuncer LI, Alacam T, Oral B. Substance P expression is elevated in inflamed human periradicular tissue. J Endod 2004, 30:329-32. 10.1097/00004770-200405000-00006, 15107644.
20. Kraneveld AD, Nijkamp FP. Tachykinins and neuro-immune interactions in asthma. Int Immunopharmacol 2001, 1:1629-50. 10.1016/S1567-5769(01)00099-6, 11562057.
21. Felten DL, Felten SY, Bellinger DL, Lorton D. Noradrenergic and peptidergic innervation of secondary lymphoid organs: role in experimental rheumatoid arthritis. Eur J Clin Invest 1992, 22(Suppl 1):37-41.
22. Levite M. Nerve-driven immunity. The direct effects of neurotransmitters on T- cell function. Ann N Y Acad Sci 2000, 917:307-21.
23. Bost KL, Pascual DW. Substance P: a late-acting B lymphocyte differentiation cofactor. Am J Physiol 1992, 262:C537-45.
24. Jain J, Loh C, Rao A. Transcriptional regulation of the IL-2 gene. Curr Opin Immunol 1995, 7:333-42. 10.1016/0952-7915(95)80107-3, 7546397.
25. Karin M, Liu Z, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol 1997, 9:240-6. 10.1016/S0955-0674(97)80068-3, 9069263.
26. Koike T, Yamagishi H, Hatanaka Y, Fukushima A, Chang JW, Xia Y, Fields M, Chandler P, Iwashima M. A novel ERK-dependent signaling process that regulates interleukin-2 expression in a late phase of T cell activation. J Biol Chem 2003, 278:15685-92. 10.1074/jbc.M210829200, 12595531.
27. Tran K, Merika M, Thanos D. Distinct functional properties of IkappaB alpha and IkappaB beta. Mol Cell Biol 1997, 17:5386-99. 232389, 9271416.
28. Gergely L, Cook L, Agnello V. A simplified method for Ca2+ flux measurement on isolated human B cells that uses flow cytometry. Clin Diagn Lab Immunol 1997, 4:70-4. 170478, 9008284.
29. Franklin RA, Tordai A, Patel H, Gardner AM, Johnson GL, Gelfand EW. Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes. J Clin Invest 1994, 93:2134-40. 10.1172/JCI117209, 294346, 8182145.
30. Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999, 401:86-90. 10.1038/43474, 10485711.
31. Feske S. Calcium signalling in lymphocyte activation and disease. Nat Rev Immunol 2007, 7:690-702. 10.1038/nri2152, 17703229.
32. Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 2005, 5:472-84. 10.1038/nri1632, 15928679.
33. Lang K, Drell TL, Niggemann B, Zanker KS, Entschladen F. Neurotransmitters regulate the migration and cytotoxicity in natural killer cells. Immunol Lett 2003, 90:165-172. 10.1016/j.imlet.2003.09.004, 14687720.
34. Bierer BE, Burakoff SJ. T cell adhesion molecules. Faseb J 1988, 2:2584-90.
35. Hemler ME, Jacobson JG, Brenner MB, Mann D, Strominger JL. VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation. Eur J Immunol 1985, 15:502-8. 10.1002/eji.1830150515, 2986987.
36. Rot A. Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration. Immunol Today 1992, 13:291-4. 10.1016/0167-5699(92)90039-A, 1510812.
37. Tanaka Y, Adams DH, Shaw S. Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes. Immunol Today 1993, 14:111-5. 10.1016/0167-5699(93)90209-4, 8466625.
38. Cinamon G, Grabovsky V, Winter E, Franitza S, Feigelson S, Shamri R, Dwir O, Alon R. Novel chemokine functions in lymphocyte migration through vascular endothelium under shear flow. J Leukoc Biol 2001, 69:860-6.
39. Tanaka Y, Adams DH, Hubscher S, Hirano H, Siebenlist U, Shaw S. T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1 beta. Nature 1993, 361:79-82. 10.1038/361079a0, 7678446.
40. Takata H, Tomiyama H, Fujiwara M, Kobayashi N, Takiguchi M. Cutting edge: expression of chemokine receptor CXCR1 on human effector CD8+ T cells. J Immunol 2004, 173:2231-5.
41. Nishimura M, Umehara H, Nakayama T, Yoneda O, Hieshima K, Kakizaki M, Dohmae N, Yoshie O, Imai T. Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression. J Immunol 2002, 168:6173-80.
42. Chuntharapai A, Lee J, Hebert CA, Kim KJ. Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes. J Immunol 1994, 153:5682-8.
43. Levite M. Towards unveiling the mystery: from stressed brain/mind to outburst of disease. Curr Opin Pharmacol 2008, 8:458-9. 10.1016/j.coph.2008.06.017, 18644465.
44. Bastian P, Posch B, Lang K, Niggemann B, Zaenker KS, Hatt H, Entschladen F. Phosphatidylinositol 3-kinase in the G protein-coupled receptor-induced chemokinesis and chemotaxis of MDA-MB-468 breast carcinoma cells: a comparison with leukocytes. Mol Cancer Res 2006, 4:411-21. 10.1158/1541-7786.MCR-06-0030, 16778088.
45. Lang K, Drell TL, Lindecke A, Niggemann B, Kaltschmidt C, Zaenker KS, Entschladen F. Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int J Cancer 2004, 112:231-8. 10.1002/ijc.20410, 15352035.
46. Bastian P, Balcarek A, Altanis C, Strell C, Niggemann B, Zaenker KS, Entschladen F. The inhibitory effect of norepinephrine on the migration of ES-2 ovarian carcinoma cells involves a Rap1-dependent pathway. Cancer Lett 2009, 274:218-24. 10.1016/j.canlet.2008.09.008, 18849110.
47. Shimizu N, Hori T, Nakane H. An interleukin-1 beta-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor: an in vivo microdialysis study in conscious rats. Brain Behav Immun 1994, 8:14-23. 10.1006/brbi.1994.1002, 8003768.
48. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-5. 10.1038/227680a0, 5432063.
49. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979, 76:4350-4. 10.1073/pnas.76.9.4350, 411572, 388439.
50. Sakkas LI, Scanzello C, Johanson N, Burkholder J, Mitra A, Salgame P, Katsetos CD, Platsoucas CD. T cells and T-cell cytokine transcripts in the synovial membrane in patients with osteoarthritis. Clin Diagn Lab Immunol 1998, 5:430-7. 95595, 9665944.
51. Bastian P, Lang K, Niggemann B, Zaenker KS, Entschladen F. Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix. Cell Mol Life Sci 2005, 62:65-76. 10.1007/s00018-004-4391-6, 15619008.
52. Strell C, Lang K, Niggemann B, Zaenker KS, Entschladen F. Surface molecules regulating rolling and adhesion to endothelium of neutrophil granulocytes and MDA-MB-468 breast carcinoma cells and their interaction. Cell Mol Life Sci 2007, 64:3306-16. 10.1007/s00018-007-7402-6, 17994288.
53. Shen DT, Ma JS, Mather J, Vukmanovic S, Radoja S. Activation of primary T lymphocytes results in lysosome development and polarized granule exocytosis in CD4+ and CD8+ subsets, whereas expression of lytic molecules confers cytotoxicity to CD8+ T cells. J Leukoc Biol 2006, 80:827-37. 10.1189/jlb.0603298, 16891618.