STAT3 polymorphisms linked with idiopathic recurrent miscarriages

American Journal of Reproductive Immunology

Volumn 63, Issue 1, 2010, Pages 22-27

  Finan, Ramzi R ^a   Mustafa, Fekriya E ^b   Al Zaman, Intissar ^b   Madan, Samira ^b   Issa, Abdalla A ^b,c   Almawi, Wassim Y ^c  

^a SAINT JOSEPH UNIVERSITY   (Lebanon)

^b Salmaniya Medical Complex ^*  (Bahrain)

^c ARABIAN GULF UNIVERSITY   (Bahrain)

Author keywords

Polymorphisms; Recurrent pregnancy loss; STAT3

Indexed keywords

HEMOGLOBIN A1C; STAT3 PROTEIN;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE FUNCTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECURRENT ABORTION; SPONTANEOUS ABORTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ABORTION, HABITUAL; ADULT; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; POLYMORPHISM, GENETIC; PREGNANCY; STAT3 TRANSCRIPTION FACTOR;

EID: 72549086982     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2009.00765.x     Document Type: Article

References (22)

1. Sierra S, Stephenson M. Genetics of recurrent pregnancy loss. Semin Reprod Med 2006, 24:17-24.
2. Bates MD, Quenby S, Takawuwa K, Johnson PM, Vince GM. Aberrant cytokine production by peripheral blood mononuclear cells in recurrent miscarriage? Hum Reprod 2002, 17:2439-2444.
3. Christiansen OB, Nielsen HS, Kolte AM. Inflammation and miscarriage. Semin Fetal Neonatal Med 2006, 11:302-308.
4. Laird SM, Tuckerman EM, Cork BA, Linjawi S, Blakemore AI, Li TC. A review of immune cells and molecules in women with recurrent miscarriage. Hum Reprod Update 2003, 9:163-174.
5. Raghupathy R. Th1-type immunity is incompatible with successful pregnancy. Immunol Today 1997, 18:478-482.
6. Bromberg J, Darnell JE. The role of STATs in transcriptional control and their impact on cellular function. Ontogeny 2000, 19:2468-2473.
7. Ren Z, Schaefer TS. ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner. J Biol Chem 2002, 277:38486-38493.
8. Dimitriadis E, Stoikos C, Tan YL, Salamonsen LA. Interleukin 11 signalling components signal transducer and activator of transcription 3 (STAT3) and suppressor of cytokine signaling 3 (SOCS3) regulate human endometrial stromal cell differentiation. Endocrinology 2006, 147:3809-3817.
9. Levy DE, Lee CK. What does Stat3 do? J Clin Invest 2002, 109:1143-1148.
10. Dimitriadis E, Sharkey AM, Tan YL, Salamonsen LA, Sherwin JR. Immunolocalisation of phosphorylated STAT3, interleukin 11 and leukaemia inhibitory factor in endometrium of women with unexplained infertility during the implantation window. Reprod Biol Endocrinol 2007, 5:44.
11. Cheng JG, Chen JR, Hernandez L, Alvord WG, Stewart CL. Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation. Proc Natl Acad Sci USA 2001, 98:8680-8685.
12. Catalano RD, Johnson MH, Campbell EA, Charnock-Jones DS, Smith SK, Sharkey AM. Inhibition of Stat3 activation in the endometrium prevents implantation: A nonsteroidal approach to contraception. Proc Natl Acad Sci USA 2005, 102:8585-8590.
13. Nakamura H, Kimura T, Koyama S, Ogita K, Tsutsui T, Shimoya N, Taniguchi T, Koyama M, Kaneda Y, Murata Y. Mouse model of human infertility: transient and local inhibition of endometrial STAT-3 activation results in implantation failure. FEBS Lett 2006, 580:2717-2722.
14. Garcia MG, Tirado-Gonzalez I, Handjiski B, Tometten M, Orsal AS, Hajos SE, Fernández N, Arck PC, Blois SM. High expression of survivin and down-regulation of Stat-3 characterize the feto-maternal interface in failing murine pregnancies during the implantation period. Placenta 2007, 28:650-657.
15. Holland SM, DeLeo FR, Elloumi HZ, Hsu AP, Uzel G, Brodsky N, Freeman AF, Demidowich A, Davis J, Turner ML, Anderson VL, Darnell DN, Welch PA, Kuhns DB, Frucht DM, Malech HL, Gallin JI, Kobayashi SD, Whitney AR, Voyich JM, Musser JM, Woellner C, Schaffer AA, Puck JM, Grimbacher B. STAT3 mutations in the hyper-IgE syndrome. N Engl J Med 2007, 357:1608-1619.
16. Sookoian S, Castaño G, Gianotti TF, Gemma C, Soledad-Rosselli M, Pirola CJ. Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease. Cytokine 2008, 44:201-206.
17. Vaclavicek A, Bermejo JL, Schmutzler RK, Sutter C, Wappenschmidt B, Meindl A, Kiechle M, Arnold N, Weber BHF, Niederacher D, Burwinkel B, Bartram CR, Hemminki K, Forsti A. Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer. Endocrine Related Cancer 2007, 14:267-277.
18. Foshay KM, Gallicano GI. miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation. Dev Biol 2009, 326:431-443.
19. El Kasmi KC, Holst J, Coffre M, Mielke L, de Pauw A, Lhocine N, Smith AM, Rutschman R, Kaushal D, Shen Y, Suda T, Donnelly RP, Myers MG, Alexander W, Vignali DA, Watowich SS, Ernst M, Hilton DJ, Murray PJ. General nature of the STAT3-activated anti-inflammatory response. J Immunol 2006, 177:7880-7888.
20. Welte T, Zhang SSM, Wang T, Zhang Z, Hesslein DGT, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell ALM, Fikrig E, Koni PA, Flavell RA, Fu X-Y. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci USA 2003, 100:1879-1884.
21. Murray PJ. The JAK-STAT signaling pathway: input and output integration. J Immunol 2007, 178:2623-2629.
22. Mercier E, Lissalde-Lavigne G, Gris J-C. JAK2 V617F mutation in unexplained loss of first pregnancy. N Engl J Med 2007, 357:1984-1985.