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Xantphos was an equally effective ligand in these reactions, but we chose the less-expensive DPEphos for the bulk of our work.
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Xantphos was an equally effective ligand in these reactions, but we chose the less-expensive DPEphos for the bulk of our work.
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Schmidt et al. (ref 9c) have reported an analogous Pd-catalyzed coupling to a 1,2-dichlorovinyl ether. Curiously, they obtained specific C-2 alkynylation.
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Schmidt et al. (ref 9c) have reported an analogous Pd-catalyzed coupling to a 1,2-dichlorovinyl ether. Curiously, they obtained specific C-2 alkynylation.
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The preparation and characterization of 28-30 are described in the Supporting Information.
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The preparation and characterization of 28-30 are described in the Supporting Information.
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The N-BOC enamides underwent Suzuki coupling but failed to cyclize under the one-pot conditions. When monoarylated N-BOC enamides were separately subjected to Pd-catalyzed cyclization conditions, cyclization did occur, but substantial loss of the BOC group was observed. See the Supporting Information for experimental details.
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The N-BOC enamides underwent Suzuki coupling but failed to cyclize under the one-pot conditions. When monoarylated N-BOC enamides were separately subjected to Pd-catalyzed cyclization conditions, cyclization did occur, but substantial loss of the BOC group was observed. See the Supporting Information for experimental details.
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