Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions

Clinical and Experimental Allergy

Volumn 39, Issue 12, 2009, Pages 1852-1856

  Kim, Sae H ^a,b   Lee, J E ^c   Kim, Sang H ^d   Jee, Y K ^e   Kim, Y K ^f   Park, H S ^g   Min, K U ^a,b   Park, H W ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c DNA Link Inc   (South Korea)

^d Eulji University   (South Korea)

^e Dankook University College of Medicine   (South Korea)

^f Pohang University of Science and Technology (POSTECH)   (South Korea)

^g Ajou University School of Medicine   (South Korea)

Author keywords

Antibiotics; CD40; CD40 ligand; Drug hypersensitivity

Indexed keywords

AMPICILLIN; CD28 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD86 ANTIGEN; CEFACLOR; CEFAZOLIN; CEFOTAXIME; CEFTRIAXONE; CEFUROXIME; CEPHALOSPORIN; CIPROFLOXACIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 1BETA; LEVOFLOXACIN; MACROLIDE; PENICILLIN G; QUINOLONE; TUMOR NECROSIS FACTOR; VANCOMYCIN;

ADULT; ANGIONEUROTIC EDEMA; ARTICLE; CONTROLLED STUDY; ERYTHEMA MULTIFORME; FEMALE; GENE INTERACTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MACULOPAPULAR RASH; MAJOR CLINICAL STUDY; MALE; PHARMACOGENETICS; PRIORITY JOURNAL; PUSTULOSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN ALLERGY; URTICARIA;

ADOLESCENT; ADULT; ALLELES; ANTI-BACTERIAL AGENTS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD40; ANTIGENS, CD86; CD40 LIGAND; DRUG ERUPTIONS; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; INTERLEUKIN-1BETA; KOREA; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 72449205949     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2009.03336.x     Document Type: Article

References (26)

1. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994 12 : 991 1045.
2. Gruchalla RS. Drug metabolism, danger signals, and drug-induced hypersensitivity. J Allergy Clin Immunol 2001 10 : 475 488.
3. Pirmohamed M, Naisbitt DJ, Gordon F, Park BK. The danger hypothesis-potential role in idiosyncratic drug reactions. Toxicology 2002 181-182 : 55 63.
4. Uetrecht J. New concepts in immunology relevant to idiosyncratic drug reactions: the "Danger Hypothesis" and innate immune system. Chem Res Toxicol 1999 12 : 387 395.
5. Pullen H, Wright N, Murdoch J. Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis. Lancet 1967 2 : 1176 1178.
6. Fischl MA, Dickinson GM, La Voie L. Safety and efficacy of sulfamethoxazole and trimethoprim chemoprophylaxis for Pneumocystis carinii pneumonia in AIDS. JAMA 1988 259 : 1185 1189.
7. Meyers DG, Gonzalez ER, Peters LL et al. Severe neutropenia associated with procainamide: comparison of sustained and conventional preparations. Am Heart J 1985 109 : 1393 1395.
8. Gallucci S, Lolkema M, Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat Med 1999 5 : 1249 1255.
9. Gallucci S, Matzinger P. Danger signals: SOS to the immune system. Curr Opin Immunol 2001 13 : 114 119.
10. Shi Y, Zheng W, Rock KL. Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc Natl Acad Sci USA 2000 97 : 14590 14595.
11. Curtsinger JM, Schmidt CS, Mondino A et al. Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol 1999 162 : 3256 3262.
12. Valeyrie-Allanore L, Sassolas B, Roujeau JC. Drug-induced skin, nail and hair disorders. Drug Saf 2007 30 : 1011 1030.
13. Park HW, Shin ES, Lee JE et al. Association between genetic variations in prostaglandin E2 receptor subtype EP3 gene (Ptger3) and asthma in the Korean population. Clin Exp Allergy 2007 37 : 1609 1615.
14. Motsinger AA, Ritchie MD, Reif DM. Novel methods for detecting epistasis in pharmacogenomics studies. Pharmacogenomics 2007 8 : 1229 1241.
15. Aiba S, Manome H, Nakagawa S et al. p38 mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene. J Invest Dermatol 2003 120 : 390 399.
16. Arrighi JF, Rebsamen M, Rousset F, Kindler V, Hauser C. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers. J Immunol 2001 166 : 3837 3845.
17. Posadas SJ, Pichler WJ. Delayed drug hypersensitivity reactions-new concepts. Clin Exp Allergy 2007 37 : 989 999.
18. Séguin B, Uetrecht J. The danger hypothesis applied to idiosyncratic drug reactions. Curr Opin Allergy Clin Immunol 2003 3 : 235 242.
19. Janeway CA. Jr. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today 1992 13 : 11 6.
20. Caproni M, Torchia D, Schincaglia E et al. The CD40/CD40 ligand system is expressed in the cutaneous lesions of erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum. Br J Dermatol 2006 154 : 319 324. (Pubitemid 43382704)
21. Barker RN, Erwig LP, Hill KS, Devine A, Pearce WP, Rees AJ. Antigen presentation by macrophages is enhanced by the uptake of necrotic, but not apoptotic, cells. Clin Exp Immunol 2002 127 : 220 225.
22. Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 2000 191 : 423 424.
23. Uetrecht J. Role of drug metabolism for breaking tolerance and the localization of drug hypersensitivity. Toxicology 2005 209 : 113 118.
24. Sanderson JP, Naisbitt DJ, Farrell J et al. Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. J Immunol 2007 178 : 5533 5542.
25. Park JH, Chang HS, Park CS et al. Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE. Am J Respir Crit Care Med 2007 175 : 775 782.
26. Mälarstig A, Lindahl B, Wallentin L, Siegbahn A. Soluble CD40L levels are regulated by the -3459 A>G polymorphism and predict myocardial infarction and the efficacy of antithrombotic treatment in non-ST elevation acute coronary syndrome. Arterioscler Thromb Vasc Biol 2006 26 : 1667 1673.