What you see is not what you get: Implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity

Malaria Journal

Volumn 8, Issue 1, 2009, Pages

  Kinyanjui, Samson M ^a,b   Bejon, Philip ^a,b   Osier, Faith H ^a,b   Bull, Peter C ^a,b   Marsh, Kevin ^a,b  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APICAL MEMBRANE 1 ANTIGEN; APICAL MEMBRANE ANTIGEN 1; MALARIA VACCINE; MEROZOITE SURFACE PROTEIN 2; MEROZOITE SURFACE PROTEIN 3; PARASITE ANTIGEN; UNCLASSIFIED DRUG; VARIANT SURFACE ANTIGEN; PROTOZOON ANTIBODY;

ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; DRUG EFFICACY; FOLLOW UP; HUMAN; IMMUNE RESPONSE; IMMUNITY; LONGITUDINAL STUDY; MALARIA; METHODOLOGY; PARASITE TRANSMISSION; BLOOD; CLINICAL TRIAL (TOPIC); IMMUNOLOGY; REVIEW;

ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CLINICAL TRIALS AS TOPIC; HUMANS; LONGITUDINAL STUDIES; MALARIA; RESEARCH DESIGN;

EID: 72449200129     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-8-242     Document Type: Article

References (52)

1. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. R Snow J Omumbo B Lowe C Molyneux J Obiero A Palmer M Weber M Pinder B Nahlen C Obonyo C Newbold S Gupta K Marsh, Lancet 1997 349 1650 4 10.1016/S0140-6736(97)02038-2 9186382
2. Malaria transmission and morbidity. K Marsh RW Snow, Parassitologia 1999 41 241 246 10697862
3. Development of vaccines against Plasmodium falciparum malaria: taking lessons from naturally acquired protective immunity. L Hviid, Microbes Infect 2007 9 772 776 10.1016/j.micinf.2007.02.008 17398137
4. Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19-kDa C-terminal fragment of the merozoite surface antigen, PfMSP-1. A Egan J Morris G Barnish S Allen B Greenwood D Kaslow A Holder E Riley, J Infect Dis 1996 173 765 769 8627050
5. Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia. BA Okech PH Corran J Todd A Joynson-Hicks C Uthaipibull TG Egwang AA Holder EM Riley, Infect Immun 2004 72 1557 1567 10.1128/IAI.72.3.1557-1567.2004 14977962
6. The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia. PH Corran RA O'Donnell J Todd C Uthaipibull AA Holder BS Crabb EM Riley, Infect Immun 2004 72 6185 6189 10.1128/IAI.72.10.6185-6189.2004 15385530
7. High levels of serum antibodies to merozoite surface protein 2 of Plasmodium falciparum are associated with reduced risk of clinical malaria in coastal Kenya. SD Polley DJ Conway DR Cavanagh JS McBride BS Lowe TN Williams TW Mwangi K Marsh, Vaccine 2006 24 4233 4246 10.1016/j.vaccine.2005.06.030 16111789
8. Plasmodium falciparum merozoite surface protein 3 is a target of allele-specific immunity and alleles are maintained by natural selection. SD Polley KK Tetteh JM Lloyd OJ Akpogheneta BM Greenwood KA Bojang DJ Conway, J Infect Dis 2007 195 279 287 10.1086/509806 17191173
9. Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria. FH Osier G Fegan SD Polley L Murungi F Verra KK Tetteh B Lowe T Mwangi PC Bull AW Thomas DR Cavanagh JS McBrider D Lanar M Mackinnon DJ Conway K Marsh, Infect Immun 2008 76 5 2240 8 10.1128/IAI.01585-07 18316390
10. Immune effector mechanisms in malaria. K Marsh S Kinyanjui, Parasite Immunol 2006 28 51 60 10.1111/j.1365-3024.2006.00808.x 16438676
11. Longitudinal study on the in vitro immune response to Plasmodium falciparum in Sudan. JA Vande Waa JB Jensen MA Akood R Bayoumi, Infect Immun 1984 45 505 510 6378799
12. Human antibody response to the major merozoite surface antigen of Plasmodium falciparum is strain specific and short-lived. K Fruh O Doumbo HM Muller O Koita J McBride A Crisanti Y Toure H Bujard, Infect Immun 1991 59 1319 1324 2004813
13. A longitudinal study of type-specific antibody responses to Plasmodium falciparum merozoite surface protein-1 in an area of unstable malaria in Sudan. DR Cavanagh IM Elhassan C Roper VJ Robinson H Giha AA Holder L Hviid TG Theander DE Arnot JS McBride, J Immunol 1998 161 347 359 9647243
14. Seasonal variation in agglutination of Plasmodium falciparum-infected erythrocytes. HA Giha TG Theander T Staalso C Roper IM Elhassan H Babiker GM Satti DE Arnot L Hviid, Am J Trop Med Hyg 1998 58 399 405 9574782
15. Do antibody responses to malaria vaccine candidates influenced by the level of malaria transmission protect from malaria? I Nebie AB Tiono DA Diallo S Samandoulougou A Diarra AT Konate N Cuzin-Ouattara M Theisen G Corradin S Cousens AS Ouattara E Ilboudo-Sanogo BS Sirima, Trop Med Int Health 2008 13 229 237 18304269
16. Humoral response to Plasmodium falciparum ring-infected erythrocyte surface antigen in a highly endemic area of Papua New Guinea. F al-Yaman B Genton M Falk RF Anders D Lewis J Hii HP Beck MP Alpers, Am J Trop Med Hyg 1995 52 66 71 7856827
17. Plasmodium falciparum Infections Are Associated with Agglutinating Antibodies to Parasite-Infected Erythrocyte Surface Antigens among Healthy Kenyan Children. PC Bull BS Lowe N Kaleli F Njuga M Kortok A Ross F Ndungu RW Snow K Marsh, J Infect Dis 2002 185 1688 1691 10.1086/340420 12023781
18. Protection against clinical malaria by heterologous immunoglobulin G antibodies against malaria-infected erythrocyte variant surface antigens requires interaction with asymptomatic infections. SM Kinyanjui T Mwangi PC Bull CI Newbold K Marsh, J Infect Dis 2004 190 1527 1533 10.1086/424675 15478055
19. A longitudinal study of naturally acquired cellular and humoral immune responses to a merozoite surface protein (MSP1) of Plasmodium falciparum in an area of seasonal malaria transmission. E Riley JS Morris M Blackman B Greenwood A Holder, Parasite Immunol 1993 15 513 24 10.1111/j.1365-3024.1993.tb00639.x 7877849
20. Selective recognition of malaria antigens by human serum antibodies is not genetically determined but demonstrates some features of clonal imprinting. RR Taylor A Egan D McGuinness A Jepson R Adair C Drakely E Riley, Int Immunol 1996 8 905 915 10.1093/intimm/8.6.905 8671680
21. A longitudinal investigation of IgG and IgM antibody responses to the merozoite surface protein-1 19-kiloDalton domain of Plasmodium falciparum in pregnant women and infants: associations with febrile illness, parasitemia, and anemia. O Branch V Udhayakumar A Hightower A Oloo W Hawley B Nahlen P Bloland D Kaslow A Lal, Am J Trop Med Hyg 1998 58 211 9 9502606
22. A longitudinal study of human antibody responses to Plasmodium falciparum rhoptry-associated protein 1 in a region of seasonal and unstable malaria transmission. PN Fonjungo IM Elhassan DR Cavanagh TG Theander L Hviid C Roper DE Arnot JS McBride, Infect Immun 1999 67 2975 2985 10338508
23. IgG antibody responses to Plasmodium falciparum merozoite antigens in Kenyan children have a short half-life. SM Kinyanjui DJ Conway DE Lanar K Marsh, Malar J 2007 6 82 10.1186/1475-2875-6-82 17598897
24. Metabolic properties of IgG subclasses in man. A Morell WD Terry TA Waldmann, J Clin Invest 1970 49 673 680 10.1172/JCI106279 5443170
25. Natural immune response to the C-terminal 19-kilodalton domain of Plasmodium falciparum merozoite surface protein 1. Y Shi U Sayed S Qari J Roberts V Udhayakumar A Oloo W Hawley D Kaslow B Nahlen A Lal, Infect Immun 1996 64 2716 23 8698500
26. Atypical IgG subclass antibody responses to Plasmodium falciparum asexual stage antignes. A Ferrante C Rzepczyk, Parasitol Today 1997 13 145 148 10.1016/S0169-4758(97)89812-2 15275101
27. Humoral immune responses of Solomon Islanders to the merozoite surface antigen 2 of Plasmodium falciparum show pronounced skewing towards antibodies of the immunoglobulin G3 subclass. CM Rzepczyk K Hale N Woodroffe A Bobogare P Csurhes A Ishii A Ferrante, Infect Immun 1997 65 1098 1100 9038322
28. IgG3 antibodies to Plasmodium falciparum merozoite surface protein 2 (MSP2): increasing prevalence with age and association with clinical immunity to malaria. RR Taylor SJ Allen BM Greenwood EM Riley, Am J Trop Med Hyg 1998 58 406 413 9574783
29. Plasmodium chabaudi chabaudi infection in mice induces strong B cell responses and striking but temporary changes in splenic cell distribution. AH Achtman M Khan IC MacLennan J Langhorne, J Immunol 2003 171 317 324 12817013
30. Multiple cross-reactivities amongst antigens of Plasmodium falciparum impair the development of protective immunity against malaria. RF Anders, Parasite Immunol 1986 8 529 539 10.1111/j.1365-3024.1986.tb00867.x 3543808
31. B Cell Memory to 3 Plasmodium falciparum Blood-Stage Antigens in a Malaria-Endemic Area. JR Dorfman P Bejon FM Ndungu J Langhorne MM Kortok BS Lowe TW Mwangi TN Williams K Marsh, J Infect Dis 2005 191 1623 1630 10.1086/429671 15838788
32. Heterogeneities in the transmission of infectious agents: implications for the design of control programs. ME Woolhouse C Dye JF Etard T Smith JD Charlwood GP Garnett P Hagan JL Hii PD Ndhlovu RJ Quinnell CH Watts SK Chandiwana RM Anderson, Proc Natl Acad Sci USA 1997 94 338 342 10.1073/pnas.94.1.338 8990210
33. The entomological inoculation rate and Plasmodium falciparum infection in African children. DL Smith J Dushoff RW Snow SI Hay, Nature 2005 438 492 495 10.1038/nature04024 16306991
34. Transmission and immunity: the importance of heterogeneity in the fight against malaria. GJ Filion RE Paul V Robert, Trends Parasitol 2006 22 345 348 10.1016/j.pt.2006.06.005 16797234
35. Spatial targeting of interventions against malaria. R Carter KN Mendis D Roberts, Bull World Health Organ 2000 78 1401 1411 11196487
36. Factors Determining the Heterogeneity of Malaria Incidence in Children in Kampala, Uganda. TD Clark B Greenhouse D Njama-Meya B Nzarubara C Maiteki-Sebuguzi SG Staedke E Seto MR Kamya PJ Rosenthal G Dorsey, J Infect Dis 2008 198 1 7 10.1086/589778 18544010
37. Evidence for over-dispersion in the distribution of clinical malaria episodes in children. TW Mwangi G Fegan TN Williams SM Kinyanjui RW Snow K Marsh, PLoS ONE 2008 3 2196 10.1371/journal.pone.0002196 18493319
38. Eleven years of malaria surveillance in a Sudanese village highlights unexpected variation in individual disease susceptibility and outbreak severity. A Creasey H Giha AA Hamad IM El Hassan TG Theander DE Arnot, Parasitology 2004 129 263 271 10.1017/S0031182004005724 15471002
39. The risk of a mosquito-borne infection in a heterogeneous environment. DL Smith J Dushoff FE McKenzie, PLoS Biol 2004 2 368 10.1371/journal.pbio.0020368 15510228
40. Micro-epidemiology of Plasmodium falciparum malaria: Is there any difference in transmission risk between neighbouring villages? Y Ye C Kyobutungi VR Louis R Sauerborn, Malar J 2007 6 46 10.1186/1475-2875-6-46 17445255
41. Space-time clustering of childhood malaria at the household level: a dynamic cohort in a Mali village. J Gaudart B Poudiougou A Dicko S Ranque O Toure I Sagara M Diallo S Diawara A Ouattara M Diakite OK Doumbo, BMC Public Health 2006 6 286 10.1186/1471-2458-6-286 17118176
42. High spatial resolution mapping of malaria transmission risk in the Gambia, west Africa, using LANDSAT TM satellite imagery. C Bogh SW Lindsay SE Clarke A Dean M Jawara M Pinder CJ Thomas, Am J Trop Med Hyg 2007 76 875 881 17488908
43. Topography-derived wetness indices are associated with household-level malaria risk in two communities in the western Kenyan highlands. JM Cohen KC Ernst KA Lindblade JM Vulule CC John ML Wilson, Malar J 2008 7 40 10.1186/1475-2875-7-40 18312633
44. Spatial and temporal variation in malaria transmission in a low endemicity area in northern Tanzania. MJ Oesterholt JT Bousema OK Mwerinde C Harris P Lushino A Masokoto H Mwerinde FW Mosha CJ Drakeley, Malar J 2006 5 98 10.1186/1475-2875-5-98 17081311
45. Heritability of malaria in Africa. MJ Mackinnon TW Mwangi RW Snow K Marsh TN Williams, PLoS Med 2005 2 340 10.1371/journal.pmed.0020340 16259530
46. Estimation of heterogeneity in malaria transmission by stochastic modelling of apparent deviations from mass action kinetics. TA Smith, Malar J 2008 7 12 10.1186/1475-2875-7-12 18190717
47. Host-specific cues cause differential attractiveness of Kenyan men to the African malaria vector Anopheles gambiae. WR Mukabana W Takken R Coe BG Knols, Malar J 2002 1 17 10.1186/1475-2875-1-17 12513703
48. Immunity to febrile malaria in children: an analysis that distinguishes immunity from lack of exposure. P Bejon G Warimwe CL Mackintosh MJ Mackinnon SM Kinyanjui JN Musyoki P Bull K Marsh, Infect Immun 2009 77 1917 23 10.1128/IAI.01358-08 19223480
49. A retrospective examination of the patterns of recrudescence in patients infected with Plasmodium falciparum. WE Collins GM Jeffery, Am J Trop Med Hyg 1999 61 44 48 10432044
50. Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria. SD Polley T Mwangi CH Kocken AW Thomas S Dutta DE Lanar E Remarque A Ross TN Williams G Mwambingu, et al. Vaccine 2004 23 718 728 10.1016/j.vaccine.2004.05.031 15542195
51. Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3. FH Osier SD Polley T Mwangi B Lowe DJ Conway K Marsh, Parasite Immunol 2007 29 387 394 10.1111/j.1365-3024. 2007.00951.x 17650180
52. Failure to respond to the surface of Plasmodium falciparum infected erythrocytes predicts susceptibility to clinical malaria amongst African children. CL Mackintosh T Mwangi SM Kinyanjui M Mosobo R Pinches TN Williams CI Newbold K Marsh, Int J Parasitol 2008 38 1445 1454 10.1016/j.ijpara.2008.03.009 18534600