Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19-kDa C-terminal fragment of the merozoite surface antigen, PfMSP-1

Journal of Infectious Diseases

Volumn 173, Issue 3, 1996, Pages 765-769

  Egan, Andréa F ^d   Morris, Joanne ^d   Barnish, Guy ^b   Allen, Stephen ^c   Greenwood, Brian M ^d   Kaslow, David C ^d   Holder, Anthony A ^d   Riley, Eleanor M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; IMMUNOGLOBULIN G; PARASITE ANTIGEN; PFMSP 1; PROTOZOON ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHILD; CONTROLLED STUDY; GAMBIA; HUMAN; HUMAN TISSUE; IMMUNITY; INFANT; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MEROZOITE; NEWBORN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SERUM; SIERRA LEONE;

EID: 0030047110     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/173.3.765     Document Type: Article

References (5)

1. Perrin LH, Merkli B, Loche M, Chizzolini C, Smart J, Richle R. Antimalarial immunity in Saimiri monkeys. Immunization with surface components of asexual blood stages. J Exp Med 1984;160:441-51.
2. Siddiqui WA, Tam LQ, Kramer KJ, et al. Merozoite surface coat precursor protein completely protects aotus monkeys against Plasmodium falciparum malaria. Proc Natl Acad Sci USA 1987;84:3014-8.
3. Blackman MJ, Heidrich HG, Donachie S, McBride JS, Holder AA. A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-blocking antibodies. J Exp Med 1990;172:379-82.
4. Ling IT, Ogun SA, Holder AA. Immunization against malaria with a recombinant protein. Parasite Immunol 1994;16:63-7.
5. Riley EM, Allen SJ, Wheeler J, et al. Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen of Plasmodium falciparum are associated with reduced malaria morbidity. Parasite Immunol 1992;14:321-38.