SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells

Biochemical Journal

Volumn 425, Issue 1, 2010, Pages 95-105

  Ng, Dominic C H ^a   Lim, Cheh P ^b   Lin, Bao H ^b,c   Zhang, Tong ^b,d   Cao, Xinmin ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^d EMD Biosciences Inc   (United States)

Author keywords

Breast cancer; Epithelial cadherin (E cadherin); Microtubule; Oncostatin M; Signal transducer and activator of transcription 3 (STAT3); Superior cervical ganglia protein 10 like protein (SCLIP)

Indexed keywords

BREAST CANCER; E-CADHERINS; EPITHELIAL CADHERIN; EPITHELIAL CADHERIN (E-CADHERIN); MICROTUBULES; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3); SIGNAL TRANSDUCERS;

COMPUTER SOFTWARE MAINTENANCE; CYTOLOGY; MONOLAYERS; MORPHOLOGY; PIEZOELECTRIC TRANSDUCERS; PROTEINS; TRANSCRIPTION;

CELLS;

MYC PROTEIN; ONCOSTATIN M; SMALL INTERFERING RNA; STAT3 PROTEIN; SUPERIOR CERVICAL GANGLIA PROTEIN 10 LIKE PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; EPITHELIAL CELLS; HELA CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LUCIFERASES; MICROSCOPY, FLUORESCENCE; ONCOSTATIN M; PC12 CELLS; PROTEIN BINDING; RATS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STATHMIN;

EID: 72449181808     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091213     Document Type: Article

References (38)

1. Levy, D. E. and Darnell, Jr, J. E. (2002) STATs: transcriptional control and biological impact. Nat. Rev. 3, 651-662
2. Levy, D. E. and Lee, C. K. (2002) What does Stat3 do? J. Clin. Invest. 109, 1143-1148
3. Lutticken, C., Coffer, P., Yuan, J., Schwartz, C., Caldenhoven, E., Schindler, C., Kruijer, W., Heinrich, P. C. and Horn, F. (1995) Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. FEBS Lett. 360, 137-143
4. Heim, M. H., Kerr, I. M., Stark, G. R. and Darnell, Jr, J. E. (1995) Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267, 1347-1349
5. Ng, D. C., Lin, B. H., Lim, C. P., Huang, G., Zhang, T., Poli, V. and Cao, X. (2006) Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J. Cell Biol. 172, 245-257
6. Silver, D. L., Naora, H., Liu, J., Cheng, W. and Montell, D. J. (2004) Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. Cancer Res. 64, 3550-3558
7. Bromberg, J. and Darnell, Jr, J. E. (2000) The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19, 2468-2473
8. Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C. and Darnell, Jr, J. E. (1999) Stat3 as an oncogene. Cell 98, 295-303
9. Song, J. I. and Grandis, J. R. (2000) STAT signaling in head and neck cancer. Oncogene 19, 2489-2495
10. Garcia, R., Bowman, T. L., Niu, G., Yu, H., Minton, S., Muro-Cacho, C. A., Cox, C. E., Falcone, R., Fairclough, R., Parsons, S. et al. (2001) Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 20, 2499-2513
11. Zhang, F., Li, C., Halfter, H. and Liu, J. (2003) Delineating an oncostatin M-activated STAT3 signaling pathway that coordinates the expression of genes involved in cell cycle regulation and extracellular matrix deposition of MCF-7 cells. Oncogene 22, 894-905
12. Douglas, A. M., Grant, S. L., Goss, G. A., Clouston, D. R., Sutherland, R. L. and Begley, C. G. (1998) Oncostatin M induces the differentiation of breast cancer cells. Int. J. Cancer 75, 64-73
13. Lo, H. W., Hsu, S. C., Xia, W., Cao, X., Shih, J. Y., Wei, Y., Abbruzzese, J. L., Hortobagyi, G. N. and Hung, M. C. (2007) Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res. 67, 9066-9076
14. Gumbiner, B. M. (2000) Regulation of cadherin adhesive activity. J. Cell Biol. 148, 399-404
15. Cowin, P., Rowlands, T. M. and Hatsell, S. J. (2005) Cadherins and catenins in breast cancer. Curr. Opin. Cell Biol. 17, 499-508
16. Darnell, Jr, J. E., Kerr, I. M. and Stark, G. R. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421
17. Nightingale, J., Patel, S., Suzuki, N., Buxton, R., Takagi, K. I., Suzuki, J., Sumi, Y., Imaizumi, A., Mason, R. M. and Zhang, Z. (2004) Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation. J. Am. Soc. Nephrol. 15, 21-32
18. 705 phosphorylation by Smad4 suppresses transforming growth factor β-mediated invasion and metastasis in pancreatic cancer cells. Cancer Res. 68, 4221-4228
19. Azare, J., Leslie, K., Al-Ahmadie, H., Gerald, W., Weinreb, P. H., Violette, S. M. and Bromberg, J. (2007) Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin β6. Mol. Cell. Biol. 27, 4444-4453
20. Cassimeris, L. (2002) The oncoprotein 18/stathmin family of microtubule destabilizers. Curr. Opin. Cell Biol. 14, 18-24
21. Gavet, O., El Messari, S., Ozon, S. and Sobel, A. (2002) Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons. J. Neurosci. Res. 68, 535-550
22. Gavet, O., Ozon, S., Manceau, V., Lawler, S., Curmi, P. and Sobel, A. (1998) The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. J. Cell Sci. 111, 3333-3346
23. Bieche, I., Maucuer, A., Laurendeau, I., Lachkar, S., Spano, A. J., Frankfurter, A., Levy, P., Manceau, V., Sobel, A., Vidaud, M. and Curmi, P. A. (2003) Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP. Genomics 81, 400-410
24. Rubin, C. I. and Atweh, G. F. (2004) The role of stathmin in the regulation of the cell cycle. J. Cell. Biochem. 93, 242-250
25. Singer, S., Malz, M., Herpel, E., Warth, A., Bissinger, M., Keith, M., Muley, T., Meister, M., Hoffmann, H., Penzel, R. et al. (2009) Coordinated expression of stathmin family members by far upstream sequence element-binding protein-1 increases motility in non-small cell lung cancer. Cancer Res. 69, 2234-2243
26. Subramaniam, V. N., Loh, E., Horstmann, H., Habermann, A., Xu, Y., Coe, J., Griffiths, G. and Hong, W. (2000) Preferential association of syntaxin 8 with the early endosome. J. Cell Sci. 113, 997-1008
27. Rios, R. M., Sanchis, A., Tassin, A. M., Fedriani, C. and Bornens, M. (2004) GMAP-210 recruits γ-tubulin complexes to cis-Golgi membranes and is required for Golgi ribbon formation. Cell 118, 323-335
28. Huang, G., Lu, H., Hao, A., Ng, D. C., Ponniah, S., Guo, K., Lufei, C., Zeng, Q. and Cao, X. (2004) GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I. Mol. Cell. Biol. 24, 8447-8456
29. Gough, D. J., Corlett, A., Schlessinger, K., Wegrzyn, J., Larner, A. C. and Levy, D. E. (2009) Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science 324, 1713-1716
30. Kermorgant, S. and Parker, P. J. (2008) Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation. J. Cell Biol. 182, 855-863
31. Baldassa, S., Gnesutta, N., Fascio, U., Sturani, E. and Zippel, R. (2007) SCLIP, a microtubule-destabilizing factor, interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth. J. Biol. Chem. 282, 2333-2345
32. Kang, S. W., Shin, Y. J., Shim, Y. J., Jeong, S. Y., Park, I. S. and Min, B. H. (2005) Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells. Exp. Cell Res. 309, 305-315
33. Mahapatra, N. R., Taupenot, L., Courel, M., Mahata, S. K. and O'Connor, D. T. (2008) The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. Biochemistry 47, 7167-7178
34. Bryant, D. M. and Stow, J. L. (2004) The ins and outs of E-cadherin trafficking. Trends Cell Biol. 14, 427-434
35. Poulain, F. E., Chauvin, S., Wehrle, R., Desclaux, M., Mallet, J., Vodjdani, G., Dusart, I. and Sobel, A. (2008) SCLIP is crucial for the formation and development of the Purkinje cell dendritic arbor. J. Neurosci. 28, 7387-7398
36. Poulain, F. E. and Sobel, A. (2007) The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10. Mol. Cell. Neurosci. 34, 137-146
37. Walter-Yohrling, J., Cao, X., Callahan, M., Weber, W., Morgenbesser, S., Madden, S. L., Wang, C. and Teicher, B. A. (2003) Identification of genes expressed in malignant cells that promote invasion. Cancer Res. 63, 8939-8947
38. Ling, X. and Arlinghaus, R. B. (2005) Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice. Cancer Res. 65, 2532-2536