Phellinins A1 and A2, new styrylpyrones from the culture broth of Phellinus sp. KACC93057P: I. Fermentation, taxonomy, isolation and biological properties

Journal of Antibiotics

Volumn 62, Issue 11, 2009, Pages 631-634

  Lee, In Kyoung ^a   Seo, Geon Sik ^b   Jeon, Nak Beom ^c   Kang, Hee Wan ^d   Yun, Bong Sik ^a  

^a Chonbuk National University   (South Korea)

^b National Institute of Animal Science   (South Korea)

^c Animal Plant and Fisheries Quarantine and Inspection Agency   (South Korea)

^d Hankyong National University   (South Korea)

Author keywords

Free radical scavenger; Fungal metabolite; Phellinins A1 and A2; Phellinus sp. KACC93057P; Styrylpyrone

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 1,1 DISTYRYLPYRYLETHAN; 2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); 3,14' BIHISPIDINYL; BUTYLATED HYDROXYANISOLE; CAFFEIC ACID; FREE RADICAL; HISPIDIN; HYPHOLOMINE B; INTERNAL TRANSCRIBED SPACER; PHELLININ A1; PHELLININ A2; PYRONE DERIVATIVE; RIBOSOME DNA; SCAVENGER; STYRYLPYRONE DERIVATIVE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; FERMENTATION; FUNGUS CULTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; MUSHROOM; NONHUMAN; PHELLINUS; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TAXONOMY; THIN LAYER CHROMATOGRAPHY;

BASIDIOMYCOTA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FERMENTATION; FREE RADICAL SCAVENGERS; PYRONES; STYRENES;

PHELLINUS;

EID: 72449176387     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2009.82     Document Type: Article

References (14)

1. Kim,S.D.et al. The mechanism of anti-platelet activity of davallialactone: Involvement of intracellular calcium ions, xtracellular signal-regulated kinase 2 and p38 mitogenactivated protein kinase. Eur. J. Pharmacol. 584, 361-367 (2008).
2. Lee,Y.G. et al. Src kinase-targeted anti-inflammatory activity of davallialactone from Inonotusxeranticus in ipopolysaccharide-activated RAW264.7 cells. Br. J. Pharmacol. 154, 852-863 (2008).
3. Lee, I. K. & Yun, B. S. Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus. Bioorg. Med. Chem. 15, 3309-3314 (2007).
4. Lee, I. K. & Yun, B. S. Hispidin analogs from the mushroom Inonotus xeranticus and their free radical cavenging activity. Bioorg. Med. Chem. Lett. 16, 2376-2379 (2007).
5. Lee, I. K., Kim, Y. S., Jang, Y. W., Jung, J. Y. & Yun, B. S. New antioxidant polyphenolsfrom the medicinal mushroom Inonotusobliquus. Bioorg. Med. Chem. Lett. 17, 6678-6681 (2007).
6. Lee, I. K., Seok, S. J., Kim, W. K. & Yun, B. S. Hispidin derivatives from the mushroom Inonotus xeranticus and their antioxidant activity. J. Nat. Prod. 69, 299-301 (2006).
7. Jung, J. Y. et al. Antioxidant polyphenols from the mycelia culture of the medicinal fungi Inonotusxeranticus and Phellinuslinteus. J. Appl. Microbiol. 104, 1824-1832 (2008).
8. Ward, G., Hadar, Y., Bilkis, I., Konstantinovsky, L. & Dosoretz, C. G. Initial steps of ferulic acid polymerization by lignin peroxidase. J. Biol. Chem. 276, 18734-18741 (2001).
9. Lee, I. K. & Yun, B. S. Peroxidase-mediated formation of the fungal polyphenol 3,14¢- bihispidinyl. J. Microbiol. Biotechnol. 18, 107-109 (2008).
10. Lee, I. K., Jung, J. Y., Kim, Y. H. & Yun, B. S. Phellinins A1 and A2, new styrylpyrones from the culture broth of Phellinus sp. KACC93057P: II. Physicochemical properties and structure elucidation. J. Antibiot. 62, 635-637 (2009).
11. Fiasson, J. L. Distribution of styrylpyrones in the basidiocarps of various Hymenochaetaceae.Biochem. Syst. Ecol. 10, 289-296 (1982).
12. Kang, H. W. et al. PCR based detection of Phellinus linteus using specific primers generated from universal rice primer (URP) derived PCR polymorphic band. Mycobiology 30, 202-207 (2002).
13. Graham, G. C., Mayer, S. P. & Henry, R. J. Amplified method for the preparation of fungal genomic DNA for PCR and RAPD analysis. Biotechniques 16, 175-269(1994).
14. Park, D. S. et al. PCR-based sensitive detection of wood decaying fungus Phellinuslinteusby specific primer from rDNA ITS regions. Mycobiology 29, 7-10 (2001).