Stabilization of Ca current in Purkinje neurons during high-frequency firing by a balance of Ca-dependent facilitation and inactivation

Channels

Volumn 3, Issue 6, 2009, Pages 393-401

  Benton, Mark D ^a   Raman, Indira M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Ca dependent inactivation; Cav2.1; Calcium channel; Cerebellum; P type; Spontaneous firing

Indexed keywords

BARIUM ION; CALCIUM CHANNEL P TYPE; CALCIUM ION; EGTAZIC ACID;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CALCIUM CURRENT; DEPOLARIZATION; ELECTRIC POTENTIAL; MODULATION; MOUSE; NONHUMAN; PURKINJE CELL; REPOLARIZATION; STIMULATION;

EID: 72449170528     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.3.6.9838     Document Type: Article

References (43)

1. Latham A, Paul DH. Spontaneous activity of cerebellar Purkinje cells and their responses to impulses in climbing fibres. J Physiol 1971; 213:135-156
2. Hausser M, Clark BA. Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron 1997; 19:665-678 (Pubitemid 27430752)
3. Raman IM, Bean BP. Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. J Neurosci 1997; 17:4517-4526
4. Raman IM, Bean BP. Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. J Neurosci 1999; 19:1663-1674 (Pubitemid 29094185)
5. 2+ channel family. Neuron 2003; 39:951-960
6. Fox AP, Nowycky MC, Tsien RW. Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J Physiol 1987; 394:149-172 (Pubitemid 18005128)
7. Regan LJ. Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis. J Neurosci 1991; 11:2259-2269
8. 2+ channels. Neuron 1994; 12:1301-1318
9. Lee A, Wong ST, Gallagher D, Li B, Storm DR, Scheuer T, Catterall WA. Ca2+/calmodulin binds to and modulates P/Q-type calcium channels. Nature 1999; 399:155-159 (Pubitemid 129524347)
10. 2+ channels. J Neurosci 2000; 20:6830-6838
11. 2+-binding protein 1. Nat Neurosci 2002; 5:210-217
12. Lee A, Zhou H, Scheuer T, Catterall WA. Molecular determinants of Ca(2+)/calmodulin-dependent regulation of CaV2.1 channels. Proc Natl Acad Sci USA 2003; 100:16059-16064
13. 2+ sensor proteins mediates short-term synaptic plasticity. Neuron 2008; 57:210-216
14. Mintz IM, Adams ME, Bean BP. P-type calcium channels in rat central and peripheral neurons. Neuron 1992; 9:85-95.
15. Erickson MA, Haburcak M, Smukler L, Dunlap K. Altered functional expression of Purkinje cell calcium channels precedes motor dysfunction in tottering mice. Neuroscience 2007; 150:547-555 (Pubitemid 350198736)
16. Bean BP. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 1989; 340:153-156
17. 2+/calmodulin impacts on their ability to support exocytosis in chromaffin cells. J Neurosci 2007; 27:5236-5248
18. Chaudhuri D, Alseikhan BA, Chang SY, Soong TW, Yue DT. Developmental activation of calmodulin-dependent facilitation of cerebellar P-type Ca2+ current. J Neurosci 2005; 25:8282-8294 (Pubitemid 41292123)
19. Levin SI, Khaliq ZM, Aman TK, Grieco TM, Kearney JA, Raman IM, Meisler MH. Impaired motor function in mice with cell-specific knockout of sodium channel Scn8a (NaV1.6) in cerebellar purkinje neurons and granule cells. J Neurophysiol 2006; 96:785-793
20. Hansen AJ. Effect of anoxia on ion distribution in the brain. Physiol Rev 1985; 65:101-148 (Pubitemid 15165386)
21. McDonough SI, Bean BP. Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons. Mol Pharmacol 1998; 54:1080-1087 (Pubitemid 29002052)
22. Khaliq ZM, Raman IM. Axonal propagation of simple and complex spikes in cerebellar Purkinje neurons. J Neurosci 2005; 25:454-463
23. Llinas R, Sugimori M, Simon SM. Transmission by presynaptic spike-like depolarization in the squid giant synapse. Proc Natl Acad Sci USA 1982; 79:2415-2419 (Pubitemid 12161333)
24. 2+ channels. Nature 2001; 411:484-489
25. Borst JG, Sakmann B. Facilitation of presynaptic calcium currents in the rat brainstem. J Physiol 1998; 513:149-155 (Pubitemid 28528573)
26. Xu J, Wu LG. The decrease in the presynaptic calcium current is a major cause of short-term depression at a calyx-type synapse. Neuron 2005; 46:633-645 (Pubitemid 40797387)
27. Currie KP, Fox AP. Differential facilitation of N- and P/Q-type calcium channels during trains of action potential-like waveforms. J Physiol 2002; 539:419-431
28. 2+-channels: four subtypes of alpha1- and beta-subunits in developing and mature rat brain. Brain Res Mol Brain Res 1995; 30:1-16.
29. Ludwig A, Flockerzi V, Hofmann F. Regional expression and cellular localization of the alpha1 and beta subunit of high voltage-activated calcium channels in rat brain. J Neurosci 1997; 17:1339-1349 (Pubitemid 27073735)
30. 2+ channels. J Neurosci 2004; 24:6334-6342
31. V2.1 P/Q-type calcium channel alternative splicing affects the functional impact of familial hemiplegic migraine mutations: implications for calcium channelopathies. Channels 2009; 3:110-121
32. Fierro L, Llano I. High endogenous calcium buffering in Purkinje cells from rat cerebellar slices. J Physiol 1996; 496:617-625 (Pubitemid 26387847)
33. 2+ buffering in Purkinje neurons. Neuron 1999; 24:989-1002.
34. 2+ channels. J Biol Chem 2006; 281:4691-4698
35. Womack MD, Khodakhah K. Somatic and dendritic small-conductance calcium-activated potassium channels regulate the output of cerebellar purkinje neurons. J Neurosci 2003; 23:2600-2607 (Pubitemid 36418594)
36. + channels to rat Purkinje neuron function. J Physiol 2003; 548:53-69.
37. Womack MD, Chevez C, Khodakhah K. Calcium-activated potassium channels are selectively coupled to P/Q-type calcium channels in cerebellar Purkinje neurons. J Neurosci 2004; 24:8818-8822 (Pubitemid 39362976)
38. Walter JT, Alvina K, Womack MD, Chevez C, Khodakhah K. Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia. Nat Neurosci 2006; 9:389-397 (Pubitemid 43290969)
39. Forsythe ID, Tsujimoto T, Barnes-Davies M, Cuttle MF, Takahashi T. Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse. Neuron 1998; 20:797-807. (Pubitemid 28199057)
40. van den Maagdenberg AM, Pietrobon D, Pizzorusso T, Kaja S, Broos LA, Cesetti T, et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron 2004; 41:701-710 (Pubitemid 38326833)
41. V2.1 calcium channels produced by mutation S218L causing familial hemiplegic migraine and delayed cerebral edema and coma after minor head trauma. J Biol Chem 2005; 280:17678-17686
42. Telgkamp P, Padgett DE, Ledoux VA, Woolley CS, Raman IM. Maintenance of high-frequency transmission at purkinje to cerebellar nuclear synapses by spillover from boutons with multiple release sites. Neuron 2004; 41:113-126 (Pubitemid 38068439)
43. Pugh JR, Raman IM. GABAA receptor kinetics in the cerebellar nuclei: evidence for detection of transmitter from distant release sites. Biophys J 2005; 88:1740-1754