Subcutaneous fat shows higher thyroid hormone receptor-α1 gene expression than omental fat

Obesity

Volumn 17, Issue 12, 2009, Pages 2134-2141

  Ortega, Francisco J ^a   Moreno Navarrete, José M ^a   Ribas, Vicent ^b   Esteve, Eduardo ^a   Rodriguez Hermosa, Jose I ^c   Ruiz, Bartomeu ^c   Peral, Belén ^c   Ricart, Wifredo ^a   Zorzano, Antonio ^b   Fernández Real, José M ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; RNA BINDING PROTEIN; THRSP PROTEIN, HUMAN; THYROID HORMONE RECEPTOR ALPHA; TRANSCRIPTION FACTOR;

ADIPOCYTE; ADULT; ARTICLE; COMPARATIVE STUDY; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; INTRAABDOMINAL FAT; METABOLISM; MIDDLE AGED; OBESITY; OMENTUM; STROMA CELL; SUBCUTANEOUS FAT;

ADIPOCYTES; ADULT; FEMALE; GENE EXPRESSION; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; INTRA-ABDOMINAL FAT; MIDDLE AGED; NUCLEAR PROTEINS; OBESITY; OMENTUM; RNA, MESSENGER; RNA-BINDING PROTEINS; STROMAL CELLS; SUBCUTANEOUS FAT; THYROID HORMONE RECEPTORS ALPHA; TRANSCRIPTION FACTORS;

EID: 72449167991     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2009.110     Document Type: Article

References (40)

1. Hellström L, Wahrenberg H, Reynisdottir S, Arner P. Catecholamine-induced adipocyte lipolysis in human hyperthyroidism. J Clin Endocrinol Metab 1997;82:159-166.
2. Jiang W, Miyamoto T, Kakizawa T et al. Expression of thyroid hormone receptor α in 3T3-L1 adipocytes; triiodothyronine increases the expression of lipogenic enzyme and triglyceride accumulation. J Endocrinol 2004;182:295-302.
3. Ying H, Araki O, Furuya F, Kato Y, Cheng SY. Impaired adipogenesis caused by a mutated thyroid hormone α1 receptor. Mol Cell Biol 2007;27:2359-2371.
4. Bjorntorp P. The regulation of adipose tissue distribution in humans. Int J Obes Relat Metab Disord 1996;20:291-302.
5. Cachefo A, Boucher P, Vidon C et al. Hepatic lipogenesis and cholesterol synthesis in hyperthyroid patients. J Clin Endocrinol Metab 2001;86:5353-5357.
6. Forrest D, Sjöberg M, Vennström B. Contrasting developmental and tissue-specific expression of α and β thyroid hormone receptor genes. EMBO J 1990;9:1519-1528.
7. Weiss RE, Murata Y, Cua K et al. Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor β-deficient mice. Endocrinology 1998;139:4945-4952.
8. Gullberg H, Rudling M, Forrest D, Angelin B, Vennström B. Thyroid hormone receptor β-deficient mice show complete loss of the normal cholesterol 7α-hydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterol. Mol Endocrinol 2000;14:1739-1749.
9. Ribeiro MO, Carvalho SD, Schultz JJ et al. Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific. J Clin Invest 2001;108:97-105.
10. Bernal J. Action of thyroid hormone in brain. J Endocrinol Invest 2002;25:268-288.
11. Reyne Y, Nouguès J, Cambon B, Viguerie-Bascands N, Casteilla L. Expression of c-erbAα, c-erbAβ and Rev-erbAα mRNA during the conversion of brown adipose tissue into white adipose tissue. Mol Cell Endocrinol 1996;116:59-65.
12. Lazar MA. Thyroid hormone receptors: multiple forms, multiple possibilities. Endocr Rev 1993;14:184-193.
13. Lazar MA, Chin WW. Nuclear thyroid hormone receptors. J Clin Invest 1990;86:1777-1782.
14. Hastings ML, Milcarek C, Martincic K, Peterson ML, Munroe SH. Expression of the thyroid hormone receptor gene, erbAa, in B lymphocytes: alternative mRNA processing is independent of differentiation but correlates with antisense RNA levels. Nucleic Acids Res 1997;25:4296-4300.
15. Hanamura A, Cáceres JF, Mayeda A, Franza BR, Krainer AR. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA 1998;4:430-444.
16. Hastings ML, Wilson CM, Munroe SH. A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA. RNA 2001;7:859-874.
17. Caputi M, Zahler AM. SR proteins and hnRNP H regulate the splicing of the HIV-1 tev-specific exon 6D. EMBO J 2002;21:845-855
18. Eperon IC, Makarova OV, Mayeda A et al. Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Mol Cell Biol 2000;20:8303-8318.
19. Expert-Bezançon A, Sureau A, Durosay P et al. hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of [(-tropomyosin exon 6B. J Biol Chem 2004;279:38249-38259.
20. Rooke N, Markovtsov V, Cagavi E, Black DL. Roles for SR proteins and hnRNP A1 in the regulation of c-src exon N1. Mol Cell Biol 2003;23:1874-1884
21. Lefebvre AM, Laville M, Vega N et al. Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 1998;47:98-103
22. Tchernof A, Bélanger C, Morisset AS et al. Regional differences in adipose tissue metabolism in women: minor effect of obesity and body fat distribution. Diabetes 2006;55:1353-1360.
23. Boivin A, Brochu G, Marceau S et al. Regional differences in adipose tissue metabolism in obese men. Metab Clin Exp 2007;56:533-540.
24. Vohl MC, Sladek R, Robitaille J et al. A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men. Obes Res 2004;12:1217-1222
25. LaFave LT, Augustin LB, Mariash CN. S14: insights from knockout mice. Endocrinology 2006;147:4044-4047.
26. Cáceres JF, Stamm S, Helfman DM, Krainer AR. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 1994;265:1706-1709.
27. Deurenberg P, van der Kooy K, Leenen R, Weststrate JA, Seidell JC. Sex and age specific prediction formulas for estimating body composition from bioelectrical impedance: a cross-validation study. Int J Obes 1991;15:17-25.
28. Bunnell BA, Flaat M, Gagliardi C, Patel B, Ripoll C. Adipose-derived stem cells: isolation, expansion and differentiation. Methods 2008;45:115-120.
29. Burgos-Trinidad M, Koenig RJ. Dominant negative activity of thyroid hormone receptor variant α2 and interaction with nuclear corepressors. Mol Cell Endocrinol 1999;149:107-114.
30. Bakker O, Razaki H, de Jong J, Ris-Stalpers C, Wiersinga WM. Expression of the α1, α2, and β1 T3-receptor mRNAs in the fasted rat measured using competitive PCR. Biochem Biophys Res Commun 1998;242:492-496.
31. Timmer DC, Bakker O, Wiersinga WM. Triiodothyronine affects the alternative splicing of thyroid hormone receptor α mRNA. J Endocrinol 2003;179:217-225.
32. Graveley BR. Sorting out the complexity of SR protein functions. RNA 2000;6:1197-1211.
33. Dreyfuss G, Matunis MJ, Piñol-Roma S, Burd CG. hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem 1993;62:289-321.
34. Brown SB, Maloney M, Kinlaw WB. "Spot 14" protein functions at the pretranslational level in the regulation of hepatic metabolism by thyroid hormone and glucose. J Biol Chem 1997;272:2163-2166.
35. Xiong S, Chirala SS, Hsu MH, Wakil SJ. Identification of thyroid hormone response elements in the human fatty acid synthase promoter. Proc Natl Acad Sci USA 1998;95:12260-12265.
36. Wahrenberg H, Engfeldt P, Arner P, Wennlund A, Ostman J. Adrenergic regulation of lipolysis in human adipocytes: findings in hyper-and hypothyroidism. J Clin Endocrinol Metab 1986;63:631-638.
37. Viguerie N, Millet L, Avizou S et al. Regulation of human adipocyte gene expression by thyroid hormone. J Clin Endocrinol Metab 2002;87:630-634. (Pubitemid 34158229)
38. Thijssen-Timmer DC, Peeters R P, Wouters P et al. Thyroid hormone receptor isoform expression in livers of critically ill patients. Thyroid 2007;17:105-112.
39. Williams GR, Franklyn JA, Neuberger JM, Sheppard MC. Thyroid hormone receptor expression in the "sick euthyroid" syndrome. Lancet 1989;2:1477-1481.
40. Hellmér J, Marcus C, Sonnenfeld T, Arner P. Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells. J Clin Endocrinol Metab 1992;75:15-20