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Volumn 23, Issue 12, 2009, Pages

Diagnosing and treating chronic lymphocytic leukemia in 2009

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; BENDAMUSTINE; CD38 ANTIGEN; CD5 ANTIGEN; CHLORAMBUCIL; CLADRIBINE; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLAVOPIRIDOL; FLUDARABINE; GANCICLOVIR; IMMUNOGLOBULIN HEAVY CHAIN; LENALIDOMIDE; LUMILIXIMAB; OFATUMUMAB; PENTOSTATIN; PREDNISONE; PROTEIN KINASE ZAP 70; RITUXIMAB; VALGANCICLOVIR; VINCRISTINE SULFATE;

EID: 72449142771     PISSN: 08909091     EISSN: 08909091     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (13)

References (79)
  • 1
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson BC, Bennett JM, Grever M, et al: National Cancer Institutesponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment. Blood 87:4990-4997, 1996. (Pubitemid 26189840)
    • (1996) Blood , vol.87 , Issue.12 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3    Kay, N.4    Keating, M.J.5    O'Brien, S.6    Rai, K.R.7
  • 2
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) updating the National Cancer InstituteWorking Group (NCI-WG) 1996 guidelines
    • Hallek M, Cheson BD, Catovsky D, et al: Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) updating the National Cancer InstituteWorking Group (NCI-WG) 1996 guidelines. Blood 111:5446-5456, 2008.
    • (2008) Blood , vol.111 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 3
    • 0016740933 scopus 로고
    • Clinical staging of chronic lymphocytic leukemia
    • Rai KR, Sawitsky A, Cronkite EP, et al: Clinical staging of chronic lymphocytic leukemia. Blood 46:219-234, 1975.
    • (1975) Blood , vol.46 , pp. 219-234
    • Rai, K.R.1    Sawitsky, A.2    Cronkite, E.P.3
  • 4
    • 0019427092 scopus 로고
    • A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
    • DOI 10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0. CO;2-V
    • Binet JL, Auquier A, Dighiero G, et al: A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 48:198-206, 1981. (Pubitemid 11064396)
    • (1981) Cancer , vol.48 , Issue.1 , pp. 198-206
    • Binet, J.L.1    Auquier, A.2    Dighiero, G.3
  • 5
    • 0033567968 scopus 로고    scopus 로고
    • Immunoglobulin V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al: Immunoglobulin V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94:1848-1854, 1999.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 6
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated IgVH genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, et al: Unmutated IgVH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94:1848-1854, 1999.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3
  • 8
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • Rassenti LZ, Huynh L, Toy TL, et al: ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 351:1910-1916, 2004.
    • (2004) N Engl J Med , vol.351 , pp. 1910-1916
    • Rassenti, L.Z.1    Huynh, L.2    Toy, T.L.3
  • 10
    • 0036464608 scopus 로고    scopus 로고
    • CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease
    • DOI 10.1182/blood.V99.3.1023
    • Hamblin T, Orchard J, Ibbotson R, et al: CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 99:1023-1029, 2002. (Pubitemid 34525567)
    • (2002) Blood , vol.99 , Issue.3 , pp. 1023-1029
    • Hamblin, T.J.1    Orchard, J.A.2    Ibbotson, R.E.3    Davis, Z.4    Thomas, P.W.5    Stevenson, F.K.6    Oscier, D.G.7
  • 12
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Dohner H, Stilgenbauer S, Benner A, et al: Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 343:1910-1916, 2000.
    • (2000) N Engl J Med , vol.343 , pp. 1910-1916
    • Dohner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 14
    • 0031976628 scopus 로고    scopus 로고
    • Molecular cytogenetic analysis of B-cell chronic lymphocytic leukemia
    • DOI 10.1007/s002770050373
    • Stilgenbauer S, Dohner K, Dohner H, et al: Molecular cytogenetic analysis of B-cell chronic lymphocytic leukemia. Ann Hematol 76:101-110, 1998. (Pubitemid 28224837)
    • (1998) Annals of Hematology , vol.76 , Issue.3-4 , pp. 101-110
    • Stilgenbauer, S.1    Dohner, K.2    Bentz, M.3    Lichter, P.4    Dohner, H.5
  • 15
    • 0037850927 scopus 로고    scopus 로고
    • Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy
    • DOI 10.1038/sj.cdd.4401194
    • Sturm I, Bosanquet AG, Hermann S, et al: Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy. Cell Death Differ 10:477-484, 2003. (Pubitemid 36626360)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.4 , pp. 477-484
    • Sturm, I.1    Bosanquet, A.G.2    Hermann, S.3    Guner, D.4    Dorken, B.5    Daniel, P.T.6
  • 19
    • 52649143664 scopus 로고    scopus 로고
    • Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia
    • Rassenti LZ, Jain S, Keating MJ, et al:Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia. Blood 112:1923-1930, 2008.
    • (2008) Blood , vol.112 , pp. 1923-1930
    • Rassenti, L.Z.1    Jain, S.2    Keating, M.J.3
  • 20
    • 66749168188 scopus 로고    scopus 로고
    • The role of molecular markers for predicting treatment outcomes in chronic lymphocytic leukemia
    • Rai KR: The role of molecular markers for predicting treatment outcomes in chronic lymphocytic leukemia. Clin Adv Hematol Oncol 7(3 suppl 8):6-8, 2009.
    • (2009) Clin Adv Hematol Oncol , vol.7 , Issue.3 SUPPL. 8 , pp. 6-8
    • Rai, K.R.1
  • 22
    • 0023907985 scopus 로고
    • Treatment of early chronic lymphocytic leukemia: Intermittent chlorambucil versus observation
    • Shustik C, Mick R, Silver R, et al: Treatment of early chronic lymphocytic leukemia: Intermittent chlorambucil versus observation. Hematol Oncol 6:7-12, 1988. (Pubitemid 18116323)
    • (1988) Hematological Oncology , vol.6 , Issue.1 , pp. 7-12
    • Shustik, C.1    Mick, R.2    Silver, R.3    Sawitsky, A.4    Rai, K.5    Shapiro, L.6
  • 23
    • 0026330995 scopus 로고
    • Chronic lymphocytic leukemia treatment: An interim report of PETHEMA trials
    • for the Spanish PETHEMA Group
    • Montserrat E, Fontanillas M, Estape J, for the Spanish PETHEMA Group: Chronic lymphocytic leukemia treatment: an interim report of PETHEMA trials. Leuk Lymphoma 5:89-92, 1991.
    • (1991) Leuk Lymphoma , vol.5 , pp. 89-92
    • Montserrat, E.1    Fontanillas, M.2    Estape, J.3
  • 24
    • 0033583824 scopus 로고    scopus 로고
    • Chemotherapeutic options in chronic lymphocytic leukemia: A meta-analysis of the randomized trials
    • CLL Trialists Collaborative Group
    • CLL Trialists Collaborative Group: Chemotherapeutic options in chronic lymphocytic leukemia: A meta-analysis of the randomized trials. J Natl Cancer Inst 91:861-868, 1999.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 861-868
  • 25
    • 0025910992 scopus 로고
    • Comparison of chlorambucil and prednisone versus cyclophosphamide, vincristine, and prednisone as initial treatment for chronic lymphocytic leukemia: Long-term follow-up of an Eastern Cooperative Oncology Group randomized clinical trial
    • Raphael B, Andersen JW, Silber R, et al: Comparison of chlorambucil and prednisone versus cyclophosphamide, vincristine, and prednisone as initial treatment for chronic lymphocytic leukemia: Long-term follow-up of an Eastern Cooperative Oncology Group randomized clinical trial. J Clin Oncol 9:770-776, 1991.
    • (1991) J Clin Oncol , vol.9 , pp. 770-776
    • Raphael, B.1    Andersen, J.W.2    Silber, R.3
  • 26
    • 0003108715 scopus 로고    scopus 로고
    • Comparison of high-dose chlorambucil versus Binets modified CHOP regimen in B-cell chronic lymphocytic leukemia in advanced phase: Results of an international multicentric randomized trial
    • Jaksic B, Brugiatelli M, Krc I, et al: Comparison of high-dose chlorambucil versus Binets modified CHOP regimen in B-cell chronic lymphocytic leukemia in advanced phase: results of an international multicentric randomized trial. Cancer 79:2107-2114, 1997.
    • (1997) Cancer , vol.79 , pp. 2107-2114
    • Jaksic, B.1    Brugiatelli, M.2    Krc, I.3
  • 27
    • 0025231329 scopus 로고
    • A randomized clinical trial of chlorambucil versus COP in stage B chronic lymphocytic leukemia
    • French Cooperative Group on Chronic Lymphocytic Leukemia
    • French Cooperative Group on Chronic Lymphocytic Leukemia. A randomized clinical trial of chlorambucil versus COP in stage B chronic lymphocytic leukemia. Blood 75:1422-1425, 1990.
    • (1990) Blood , vol.75 , pp. 1422-1425
  • 28
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, et al: Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 343:1750-1757, 2000.
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 29
    • 3242731873 scopus 로고    scopus 로고
    • Fludarabine (F) induces higher response rates in first line therapy of older patients (pts) with advanced chronic lymphocytic leukemia (CLL) than chlorambucil: Interim analysis of a phase III study of the German CLL Study Group (GCLLSG)
    • abstract 369
    • Eichhorst BF, Busch R, Stauch M, et al: Fludarabine (F) induces higher response rates in first line therapy of older patients (pts) with advanced chronic lymphocytic leukemia (CLL) than chlorambucil: interim analysis of a phase III study of the German CLL Study Group (GCLLSG) (abstract 369). Blood 102:109a, 2003.
    • (2003) Blood , vol.102
    • Eichhorst, B.F.1    Busch, R.2    Stauch, M.3
  • 30
    • 0035889147 scopus 로고    scopus 로고
    • Randomized comparison of fludarabine, CAP, and CHOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients
    • Leporrier M, Chevret S, Cazin B, et al: Randomized comparison of fludarabine, CAP, and CHOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients. Blood 98:2319-2325, 2001.
    • (2001) Blood , vol.98 , pp. 2319-2325
    • Leporrier, M.1    Chevret, S.2    Cazin, B.3
  • 31
    • 15844368449 scopus 로고    scopus 로고
    • Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia
    • Johnson S, Smith AG, Loffler H, et al: Multicentre prospective randomized trial of fludarabine vs cyclophosphamide, doxorubicin, and prednisone (CAP) for the treatment of advanced stage chronic lymphocytic leukemia. Lancet 347:1432-1438, 1996. (Pubitemid 26161205)
    • (1996) Lancet , vol.347 , Issue.9013 , pp. 1432-1438
    • Johnson, S.1    Smith, A.G.2    Loffler, H.3    Osby, E.4    Juliusson, G.5    Emmerich, B.6    Wyld, P.J.7    Hiddemann, W.8
  • 32
    • 0035048303 scopus 로고    scopus 로고
    • Cladribine in the treatment of chronic lymphocytic leukemia
    • Robak T: Cladribine in the treatment of chronic lymphocytic leukemia. Leuk Lymphoma 40:551-564, 2001. (Pubitemid 32303246)
    • (2001) Leukemia and Lymphoma , vol.40 , Issue.5-6 , pp. 551-564
    • Robak, T.1
  • 35
    • 24344483414 scopus 로고    scopus 로고
    • Combination chemotherapy with pentostatin, cyclophosphamide and rituximab induces high rate of remissions including complete responses and achievement of minimal residual disease in previously untreated B-chronic lymphocytic leukemia
    • abstract 339
    • Kay NE, Geyer SM, Lin T, et al: Combination chemotherapy with pentostatin, cyclophosphamide and rituximab induces high rate of remissions including complete responses and achievement of minimal residual disease in previously untreated B-chronic lymphocytic leukemia (abstract 339). Blood 104:100a, 2004.
    • (2004) Blood , vol.104
    • Kay, N.E.1    Geyer, S.M.2    Lin, T.3
  • 36
    • 33846258434 scopus 로고    scopus 로고
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
    • Kay NE, Geyer SM, Call TG, et al: Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia. Blood 109:405-411, 2007.
    • (2007) Blood , vol.109 , pp. 405-411
    • Kay, N.E.1    Geyer, S.M.2    Call, T.G.3
  • 37
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • Knauf WU, Lissichkov T, Aldaoud A, et al, Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol 27:4378-4384, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 4378-4384
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3
  • 38
    • 33947541773 scopus 로고    scopus 로고
    • Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997
    • Flinn IW, Neuberg DS, Grever MR, et al: Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J Clin Oncol 25:793-803, 2007.
    • (2007) J Clin Oncol , vol.25 , pp. 793-803
    • Flinn, I.W.1    Neuberg, D.S.2    Grever, M.R.3
  • 42
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • Huhn D, von Schilling C, Wilhelm M, et al: Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood 98:1326-1331, 2001.
    • (2001) Blood , vol.98 , pp. 1326-1331
    • Huhn, D.1    Von Schilling, C.2    Wilhelm, M.3
  • 43
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd JC, Murphy T, Howard RS, et al: Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol 19:2153-2164, 2001.
    • (2001) J Clin Oncol , vol.19 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3
  • 44
    • 0038811776 scopus 로고    scopus 로고
    • Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie Pearl Cancer Research Network
    • Hainsworth JD, Litchy S, Barton JH, et al: Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol 21: 1746-1751, 2003.
    • (2003) J Clin Oncol , vol.21 , pp. 1746-1751
    • Hainsworth, J.D.1    Litchy, S.2    Barton, J.H.3
  • 45
    • 0038446696 scopus 로고    scopus 로고
    • Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance
    • Manshouri T, Do KA, Wang X, et al: Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance. Blood 1:2507-2513, 2003.
    • (2003) Blood , vol.1 , pp. 2507-2513
    • Manshouri, T.1    Do, K.A.2    Wang, X.3
  • 49
    • 27144510745 scopus 로고    scopus 로고
    • Subcutaneous Campath-1H (alemtuzumab) in fludarabine-refractory CLL: Interim analysis of the CLL2H study of the German CLL Study Group (GCLLSG)
    • abstract 478
    • Stilgenbauer S, Winkler D, Krober A, et al: Subcutaneous Campath-1H (alemtuzumab) in fludarabine-refractory CLL: Interim analysis of the CLL2H study of the German CLL Study Group (GCLLSG) (abstract 478). Blood 104, 2004.
    • (2004) Blood , vol.104
    • Stilgenbauer, S.1    Winkler, D.2    Krober, A.3
  • 50
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T, et al: Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol 25:5616-5623, 2007.
    • (2007) J Clin Oncol , vol.25 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3
  • 52
    • 33750199616 scopus 로고    scopus 로고
    • Updated guidelines on the management of cytomegalovirus reactivation on patients with chronic lymphocytic leukemia treated with alemtuzumab
    • OBrien SM, Keating MJ, Mocarski ES: Updated guidelines on the management of cytomegalovirus reactivation in patients with chronic lymphocytic leukemia treated with alemtuzumab. Clin Lymphoma Myeloma 7:125-130, 2006. (Pubitemid 44596594)
    • (2006) Clinical Lymphoma and Myeloma , vol.7 , Issue.2 , pp. 125-130
    • O'Brien, S.M.1    Keating, M.J.2    Mocarski, E.S.3
  • 53
    • 0035412369 scopus 로고    scopus 로고
    • Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy
    • Rawstron A, Kennedy B, Evans P: Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy. Blood 98:29-35, 2001.
    • (2001) Blood , vol.98 , pp. 29-35
    • Rawstron, A.1    Kennedy, B.2    Evans, P.3
  • 56
    • 2942694373 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remissionexperience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG)
    • Wendtner C-M, Ritgen M, Schweighofer CD, et al: Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remissionexperience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG). Leukemia 18:1093-1101, 2004.
    • (2004) Leukemia , vol.18 , pp. 1093-1101
    • Wendtner, C.-M.1    Ritgen, M.2    Schweighofer, C.D.3
  • 57
    • 51249108295 scopus 로고    scopus 로고
    • Consolidation therapy with subcutaneous (SC) alemtuzumab results in severe infectious toxicity in previously untreated CLL patients who achieve a complete response (CR) after fludarabine and rituximab (FR) induction therapy: Interim safety analysis of the CALGB study 10101
    • abstract 755
    • Lin TS, Donohue KA, Lucas MS, et al: Consolidation therapy with subcutaneous (SC) alemtuzumab results in severe infectious toxicity in previously untreated CLL patients who achieve a complete response (CR) after fludarabine and rituximab (FR) induction therapy: Interim safety analysis of the CALGB study 10101 (abstract 755). Blood 110, 2007.
    • (2007) Blood , vol.110
    • Lin, T.S.1    Donohue, K.A.2    Lucas, M.S.3
  • 58
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • Byrd JC, Peterson BL, Morrison VA, et al: Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood 101:6-14, 2003.
    • (2003) Blood , vol.101 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3
  • 59
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd JC, Rai KR, Peterson BL, et al: Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 105:49-53, 2005.
    • (2005) Blood , vol.105 , pp. 49-53
    • Byrd, J.C.1    Rai, K.R.2    Peterson, B.L.3
  • 61
    • 51649093353 scopus 로고    scopus 로고
    • Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
    • Tam CS, OBrien S, Wierda W, et al: Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood 112:975-980, 2008.
    • (2008) Blood , vol.112 , pp. 975-980
    • Tam, C.S.1    OBrien, S.2    Wierda, W.3
  • 62
    • 61849091076 scopus 로고    scopus 로고
    • Immunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine and cyclophosphamide (FC) improves response rates and progression-free survival (PFS) with advanced chronic lymphocytic leukemia (CLL)
    • abstract 325
    • Hallek M, Fingerle-Rowson G, Fink AM, et al: Immunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) versus fludarabine and cyclophosphamide (FC) improves response rates and progression-free survival (PFS) with advanced chronic lymphocytic leukemia (CLL) (abstract 325). Blood 112, 2008.
    • (2008) Blood , vol.112
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.M.3
  • 63
    • 65749114275 scopus 로고    scopus 로고
    • Rituximab, fludarabine, and cyclophosphamide (R-FC) prolongs progression free survival in relapsed or refractory chronic lymphocytic leukemia compared with FC alone: Final results from the international randomized phase III REACH trial
    • abstract 1
    • Robak T, Moiseev S, Dmoszynska A, et al: Rituximab, fludarabine, and cyclophosphamide (R-FC) prolongs progression free survival in relapsed or refractory chronic lymphocytic leukemia compared with FC alone: final results from the international randomized phase III REACH trial (abstract 1). Blood 112, 2008.
    • (2008) Blood , vol.112
    • Robak, T.1    Moiseev, S.2    Dmoszynska, A.3
  • 65
    • 67749097105 scopus 로고    scopus 로고
    • Phase III trial of fludarabine, cyclophosphamide, and rituximab vs pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia
    • abstract 327
    • Reynolds C, Di Bella N, Lyons R, et al: Phase III trial of fludarabine, cyclophosphamide, and rituximab vs pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia (abstract 327). Blood 112, 2008.
    • (2008) Blood , vol.112
    • Reynolds, C.1    Di Bella, N.2    Lyons, R.3
  • 66
    • 51349108680 scopus 로고    scopus 로고
    • Clinical activity of lenalidomide in relapsed or refractory chronic lymphocytic leukemia (CLL) patients: Updated results of a phase II clinical trial
    • Chanan-Khan MK, Whitworth A, Lawrence D, et al: Clinical activity of lenalidomide in relapsed or refractory chronic lymphocytic leukemia (CLL) patients: updated results of a phase II clinical trial. Leuk Lymphoma 48:S166, 2007.
    • (2007) Leuk Lymphoma , vol.48
    • Chanan-Khan, M.K.1    Whitworth, A.2    Lawrence, D.3
  • 67
    • 45949100928 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
    • Ferrajoli A, OBrien S, Faderl SH, et al: Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 111:5291-5297, 2008.
    • (2008) Blood , vol.111 , pp. 5291-5297
    • Ferrajoli, A.1    OBrien, S.2    Faderl, S.H.3
  • 68
    • 66749113746 scopus 로고    scopus 로고
    • A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL)
    • abstract 44
    • Chen C, Harminder P, Xu W, et al: A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL) (abstract 44). Blood 112, 2008.
    • (2008) Blood , vol.112
    • Chen, C.1    Harminder, P.2    Xu, W.3
  • 69
    • 67649272030 scopus 로고    scopus 로고
    • Ofatumumab (HuMax-CD20), a novel CD20 monoclonal antibody, is an active treatment for patients with CLL refractory to both fludara-bine and alemtuzumab or bulky fludarabine refractory disease: Results from the planned interim analysis of an international pivotal trial
    • Osterborg A, Kipps TJ, Mayer J, et al: Ofatumumab (HuMax-CD20), a novel CD20 monoclonal antibody, is an active treatment for patients with CLL refractory to both fludara-bine and alemtuzumab or bulky fludarabine refractory disease: Results from the planned interim analysis of an international pivotal trial. Blood 112:328, 2008.
    • (2008) Blood , vol.112 , pp. 328
    • Osterborg, A.1    Kipps, T.J.2    Mayer, J.3
  • 70
    • 54249121052 scopus 로고    scopus 로고
    • Lumiliximab in combination with FCR for the treatment of relapsed chronic lymphoctyic leukemia (CLL): Results from a phase I/II multicenter study
    • abstract 7003
    • Byrd JC, Castro JE, Flinn IW, et al: Lumiliximab in combination with FCR for the treatment of relapsed chronic lymphoctyic leukemia (CLL): Results from a phase I/II multicenter study (abstract 7003). J Clin Oncol 26:372s, 2008.
    • (2008) J Clin Oncol , vol.26
    • Byrd, J.C.1    Castro, J.E.2    Flinn, I.W.3
  • 71
    • 69049093643 scopus 로고    scopus 로고
    • Flavopiridol (Alvocidib) induces durable responses in relapse chronic lymphoctic leukemia (CLL) patients with high-risk cytogenetic abnormalities
    • abstract 46
    • Lin TS, Heerema NA, Lozanski G, et al: Flavopiridol (Alvocidib) induces durable responses in relapse chronic lymphoctic leukemia (CLL) patients with high-risk cytogenetic abnormalities (abstract 46). Blood 112, 2008.
    • (2008) Blood , vol.112
    • Lin, T.S.1    Heerema, N.A.2    Lozanski, G.3
  • 73
    • 71649094833 scopus 로고    scopus 로고
    • Alemtuzumab and rituximab combination therapy for patients with untreated CLLa phase II trial
    • abstract 2098
    • Frankfurt O, Hamilton E, Duffey S, et al: Alemtuzumab and rituximab combination therapy for patients with untreated CLLa phase II trial (abstract 2098). Blood 112, 2008.
    • (2008) Blood , vol.112
    • Frankfurt, O.1    Hamilton, E.2    Duffey, S.3
  • 75
    • 65749110753 scopus 로고    scopus 로고
    • Bendamustine in combination with rituximab (BR) for patients with relapsed chronic lymphocytic leukemia (CLL): A multicentre phase II trial of the German CLL Study Group (GCLLSG)
    • abstract 330
    • Fischer K, Stilgenbauer S, Schweighofer CD, et al: Bendamustine in combination with rituximab (BR) for patients with relapsed chronic lymphocytic leukemia (CLL): A multicentre phase II trial of the German CLL Study Group (GCLLSG) (abstract 330). Blood 112, 2008.
    • (2008) Blood , vol.112
    • Fischer, K.1    Stilgenbauer, S.2    Schweighofer, C.D.3
  • 76
    • 24344464799 scopus 로고    scopus 로고
    • Combined cyclophosphamide, fludarabine, alemtuzumab, and rituximab (CFAR) is active for relapsed and refractory patients with CLL
    • abstract 340
    • Wierda W, Faderl S, OBrien S, et al: Combined cyclophosphamide, fludarabine, alemtuzumab, and rituximab (CFAR) is active for relapsed and refractory patients with CLL (abstract 340). Blood 104:101a, 2004.
    • (2004) Blood , vol.104
    • Wierda, W.1    Faderl, S.2    OBrien, S.3
  • 78
    • 33947312235 scopus 로고    scopus 로고
    • Predictors of improved progression-free survival after nonmyeloablative allogeneic stem cell transplantation for advanced chronic lymphocytic leukemia
    • Brown JR, Kim HT, Li S, et al: Predictors of improved progression-free survival after nonmyeloablative allogeneic stem cell transplantation for advanced chronic lymphocytic leukemia. Biol Blood Marrow Transplant 12:1056-1064, 2006.
    • (2006) Biol Blood Marrow Transplant , vol.12 , pp. 1056-1064
    • Brown, J.R.1    Kim, H.T.2    Li, S.3
  • 79
    • 33845543049 scopus 로고    scopus 로고
    • Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: The EBMT transplant consensus
    • Dreger P, Corradini P, Kimby E, et al: Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus. Leukemia 21:12-17, 2006.
    • (2006) Leukemia , vol.21 , pp. 12-17
    • Dreger, P.1    Corradini, P.2    Kimby, E.3


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