Initial blood washout during organ procurement determines liver injury and function after preservation and reperfusion

American Journal of Transplantation

Volumn 4, Issue 11, 2004, Pages 1836-1844

  'T Hart, Nils A ^a   Van Der Plaats, Arjan ^b   Leuvenink, Henri G D ^a   Wiersema Buist, Janneke ^a   Olinga, Peter ^a   Van Luyn, Marja J A ^a   Verkerke, Gijsbertus J ^b   Rakhorst, Gerhard ^b   Ploeg, Rutger J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Ischemia reperfusion injury; Liver; Organ preservation; Organ procurement; Transplantation

Indexed keywords

UNIVERSITY OF WISCONSIN SOLUTION;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD WASHOUT; CELL VIABILITY; CONTROLLED STUDY; CRYOPRESERVATION; ERYTHROCYTE; FUNCTIONAL ASSESSMENT; HIGH PRESSURE PERFUSION; HISTOLOGY; HYPOBARISM; INTERMETHOD COMPARISON; ISCHEMIA; LIVER FUNCTION; LIVER INJURY; LIVER PERFUSION; LIVER PRESERVATION; LOW PRESSURE PERFUSION; MALE; MICROVASCULATURE; NONHUMAN; ORGAN DONOR; ORGAN PRESERVATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; REPERFUSION; TIME;

EID: 7244242559     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2004.00580.x     Document Type: Article

References (32)

1. Southard JH, Belzer FO. Organ preservation. Annu Rev Med 1995; 46: 235-247.
2. Yamauchi JI, Richter S, Vollmar B, Menger MD, Minor T. Warm preflush with streptokinase improves microvascular procurement and tissue integrity in liver graft retrieval from non-heart-beating donors. Transplantation 2000; 69: 1780-1784.
3. Ploeg RJ, Goossens D, McAnulty JF, Southard JH, Belzer FO. Succesfull 72-hour cold storage of dog kidneys with UW solution. Transplantation 1988; 46: 191-196.
4. Marshall VC, Howden BO, Jablonski P et al. Analysis of UW solution in a rat liver transplant model. Transplant Proc 1990; 22: 503-505.
5. Shiiya N, Paul M, Benvenuti C, Astier A, Ferrer MJ, Loisance D. A lactobionate-based extracellular-type solution for donor heart preservation. J Heart Lung Transplant 1993; 12: 476-483.
6. Ramella-Virieux SG, Steghens JP, Barbieux A, Zech P, Pozet N, Hadj-Aissa A. Nifedipine improves recovery function of kidneys preserved in a high-sodium, low-potassium cold-storage solution: Study with the isolated perfused rat kidney technique. Nephrol Dial Transplant 1997; 12: 449-455.
7. Herrera B, Desco MM, Eisenberg G, Garcia-Barreno P, Del Canizo JF. Role of elastic fibers in cooling-induced relaxation. Cryobiology 2002; 44: 54-61.
8. Tojimbara T, Wicomb WN, Garcia-Kennedy R et al. Liver transplantation from non-heart beating donors in rats: Influence of viscosity and temperature of initial flushing solutions on graft function. Liver Transpl Surg 1997; 3: 39-45.
9. Pirenne J, Van Gelder F, Coosemans W et al. Type of donor aortic preservation solution and not cold ischemia time is a major determinant of biliary strictures after liver transplantation. Liver Transpl 2001; 7: 540-545.
10. Morariu AM, van der Plaats A, van Oeveren W et al. Hyperaggregating effect of HES components and University of Wisconsin solution on human red blood cells: A risk of impaired graft perfusion in organ procurement? Transplantation 2003; 76: 37-43.
11. Tokunaga Y, Ozaki N, Wakashiro S et al. Effects of perfusion pressure during flushing on the viability of the procured liver using noninvasive fluorometry. Transplantation 1988; 45: 1031-1035.
12. Tisone G, Vennarecci G, Baiocchi L et al. Randomized study on in situ liver perfusion techniques: Gravity perfusion vs high-pressure perfusion. Transplant Proc 1997; 29: 3460-3462.
13. van der Hoeven JA, Lindell S, van Schilfgaarde R et al. Donor brain death reduces survival after transplantation in rat livers preserved for 20 hr. Transplantation 2001; 72: 1632-1636.
14. Ville de Goyet J, Hausleithner V, Malaise J et al. Liver procurement without in situ portal perfusion. A safe procedure for more flexible multiple organ harvesting. Transplantation 1994; 57: 1328-1332.
15. Kamada N, Calne RY. Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage. Transplantation 1979; 28: 47-50.
16. Olinga P, Merema M, Hof IH et al. Effect of human liver source on the functionality of isolated hepatocytes and liver slices. Drug Metab Dispos 1998; 26: 5-11.
17. Urata K, Nguyen B, Brault A, Lavoie J, Rocheleau B, Huet PM. Decreased survival in rat liver transplantation with extended cold preservation: Role of portal vein clamping time. Hepatology 1998; 28: 366-373.
18. Zeng QH, Todo S, Murase N et al. Modified simple cold storage of rat livers with UW solution. Transplantation 1994; 58: 408-414.
19. Olinga P, Groen K, Hof IH et al. Comparison of five incubation systems for rat liver slices using functional and viability parameters. J Pharmacol Toxicol Methods 1997; 38: 59-69.
20. Martin H, Sarsat JP, Lerche-Langrand C et al. Morphological and biochemical integrity of human liver slices in long-term culture: Effects of oxygen tension. Cell Biol Toxicol 2002; 18: 73-85.
21. Martin H, Bournique B, Sarsat JP, Albaladejo V, Lerche-Langrand C. Cryopreserved rat liver slices: A critical evaluation of cell viability, histological integrity, and drug-metabolizing enzymes. Cryobiology 2000; 41: 135-144.
22. Kim SK, Belzer FO, Southard JH. Loss of mitochondrial respiratory function and its suppression during cold ischemic preservation of rat livers with University of Wisconsin solution. Hepatology 1992; 16: 742-748.
23. de Kanter R, Olinga P, Hof I et al. A rapid and simple method for cryopreservation of human liver slices. Xenobiotica 1998; 28: 225-234.
24. Siegel S, Castellan JN. Nonparametric Statistics for the Behavioral Sciences. London: McGraw-Hill Education; 1988.
25. Gebhardt R, Hengstler JG, Muller D et al. New hepatocyte in vitro systems for drug metabolism: Metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures. Drug Metab Rev 2003; 35: 145-213.
26. Vreugdenhil PK, Marsh DC, Southard JH. Comparison of isolated hepatocytes and tissue slices for study of liver hypothermic preservation/reperfusion injury. Cryobiology 1996; 33: 430-435.
27. Vajdova K, Graf R, Clavien PA. ATP-supplies in the cold-preserved liver: A long-neglected factor of organ viability. Hepatology 2002; 36: 1543-1552.
28. van der Plaats A, 't Hart NA, Morariu AM et al. Effect of University of Wisconsin organ-preservation solution on haemorheology. Transpl Int 2004; 17: 227-233.
29. Nemeto S, Aoki M, Dehua C, Imai Y. Free hemoglobin impairs cardiac function in neonatal rabbit hearts. Ann Thorac Surg 2000; 69: 1484-1489.
30. Atamna H, Ginsburg H. Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells. J Biol Chem 1995; 270: 24876-24883.
31. Sumimoto R, Kamada N, Jamieson NV, Fukuda Y, Dohi K. A comparison of a new solution combining histidine and lactobionate with UW solution and eurocollins for rat liver preservation. Transplantation 1991; 51: 589-593.
32. Jackson WF. Ion channels and vascular tone. Hypertension 2000; 35: 173-178.