NMDA receptor antagonist MK-801 reduces neuronal damage and preserves learning and memory in a rat model of traumatic brain injury

Neuroscience Bulletin

Volumn 25, Issue 6, 2009, Pages 367-375

  Han, Rui Zhang ^b   Hu, Jin Jia ^a   Weng, Yuan Chi ^a   Li, Ding Feng ^a   Huang, Yi ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b The 98th Hospital of PLA   (China)

Author keywords

Caspase 3; Learning and memory; Microglia; MK 801; Neuronal nitric oxide synthase; Traumatic brain injury

Indexed keywords

CASPASE 3; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEURONAL NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; BRAIN REGION; BRAIN TISSUE; CELL VACUOLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG MEGADOSE; IMMUNOHISTOCHEMISTRY; LEARNING; LOW DRUG DOSE; MALE; MAZE TEST; MEMORY; MICROGLIA; NERVE CELL DEGENERATION; NERVE CELL LESION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; RAT; SYNAPSE; TRAUMATIC BRAIN INJURY; TREATMENT RESPONSE;

ANIMALS; BRAIN; BRAIN INJURIES; CASPASE 3; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; LEARNING; MALE; MAZE LEARNING; MEMORY; MICROGLIA; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; NEUROPSYCHOLOGICAL TESTS; NITRIC OXIDE SYNTHASE TYPE I; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

EID: 72349087610     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12264-009-0608-x     Document Type: Article

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