메뉴 건너뛰기




Volumn 993, Issue 1-2, 2003, Pages 42-53

The neuronal nitric oxide synthase inhibitor, TRIM, as a neuroprotective agent: Effects in models of cerebral ischaemia using histological and magnetic resonance imaging techniques

Author keywords

Cerebral ischaemia; Histology; Magnetic resonance spectroscopy; Mongolian gerbil; Neuroprotection; Nitric oxide (NO); Rat; TRIM

Indexed keywords

1,2 TRIFLUOROMETHYLPHENYLIMIDAZOLE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0345714760     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2003.08.063     Document Type: Article
Times cited : (23)

References (52)
  • 1
    • 0027323351 scopus 로고
    • Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles
    • Babbedge R.C., Bland-Ward P.A., Hart S.L., Moore P.K. Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles. Br. J. Pharmacol. 110:1993;225-228.
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 225-228
    • Babbedge, R.C.1    Bland-Ward, P.A.2    Hart, S.L.3    Moore, P.K.4
  • 2
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • Beckman J.J., Beckman T.W., Chen J., Marshall D.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U. S. A. 87:1990;6120-6124.
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 6120-6124
    • Beckman, J.J.1    Beckman, T.W.2    Chen, J.3    Marshall, D.A.4    Freeman, B.A.5
  • 3
    • 0022870943 scopus 로고
    • Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats
    • Bederson J.B., Pitts L.H., Germano S.M., Nishimura M.C., Davis R.L., Bartowski H.M. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke. 17:1986;1304-1308.
    • (1986) Stroke , vol.17 , pp. 1304-1308
    • Bederson, J.B.1    Pitts, L.H.2    Germano, S.M.3    Nishimura, M.C.4    Davis, R.L.5    Bartowski, H.M.6
  • 4
    • 0022483434 scopus 로고
    • Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination
    • Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., Bartowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 17:1986;472-476.
    • (1986) Stroke , vol.17 , pp. 472-476
    • Bederson, J.B.1    Pitts, L.H.2    Tsuji, M.3    Nishimura, M.C.4    Davis, R.L.5    Bartowski, H.6
  • 5
    • 0029839695 scopus 로고    scopus 로고
    • Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model
    • Belayev L., Alonso O.F., Busto R., Zhao W., Ginsberg M.D. Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke. 27:1996;1616-1622.
    • (1996) Stroke , vol.27 , pp. 1616-1622
    • Belayev, L.1    Alonso, O.F.2    Busto, R.3    Zhao, W.4    Ginsberg, M.D.5
  • 6
    • 0029133583 scopus 로고
    • The antioxidant LY231617 ameliorates functional and morphological sequelae induced by global ischaemia in rats
    • Block F., Schmitt W., Schwarz M. The antioxidant LY231617 ameliorates functional and morphological sequelae induced by global ischaemia in rats. Brain Res. 694:1995;308-311.
    • (1995) Brain Res. , vol.694 , pp. 308-311
    • Block, F.1    Schmitt, W.2    Schwarz, M.3
  • 7
    • 0027236232 scopus 로고
    • Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia
    • Buisson A., Margaill I., Callebert J., Plotkine M., Boulu R.G. Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia. J. Neurochem. 61:1993;690-696.
    • (1993) J. Neurochem. , vol.61 , pp. 690-696
    • Buisson, A.1    Margaill, I.2    Callebert, J.3    Plotkine, M.4    Boulu, R.G.5
  • 8
    • 0028972995 scopus 로고
    • G-nitro-L-arginine methyl ester protects against lipid peroxidation in the gerbil following cerebral ischaemia
    • G-nitro-L-arginine methyl ester protects against lipid peroxidation in the gerbil following cerebral ischaemia. Eur. J. Pharmacol. 285:1995;203-206.
    • (1995) Eur. J. Pharmacol. , vol.285 , pp. 203-206
    • Caldwell, M.1    O'Neill, M.2    Earley, B.3    Kelly, J.P.4    Leonard, B.E.5
  • 9
    • 0035968064 scopus 로고    scopus 로고
    • Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain
    • Cash D., Beech J.S., Rayne R.C., Bath P.M.W., Meldrum B.S., Williams S.C.R. Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain. Brain Res. 905:2001;91-103.
    • (2001) Brain Res. , vol.905 , pp. 91-103
    • Cash, D.1    Beech, J.S.2    Rayne, R.C.3    Bath, P.M.W.4    Meldrum, B.S.5    Williams, S.C.R.6
  • 10
    • 0032797262 scopus 로고    scopus 로고
    • Nitric oxide synthases: Targets for therapeutic strategies in neurological diseases
    • Chabrier P.-E., Demerlé-Pallardy C., August M. Nitric oxide synthases: targets for therapeutic strategies in neurological diseases. CMLS Cell. Mol. Life Sci. 55:1999;1029-1035.
    • (1999) CMLS Cell. Mol. Life Sci. , vol.55 , pp. 1029-1035
    • Chabrier, P.-E.1    Demerlé-Pallardy, C.2    August, M.3
  • 11
    • 0027490697 scopus 로고
    • Nitric oxide: Foe or friend to the injured brain?
    • Choi D.W. Nitric oxide: foe or friend to the injured brain? Proc. Natl. Acad. Sci. U. S. A. 90:1993;9741-9743.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 9741-9743
    • Choi, D.W.1
  • 12
    • 0027167648 scopus 로고
    • The antioxidant LY231617 reduces global ischemic neuronal injury in rats
    • Clemens J.A., Saunders R.D., Ho P.P., Phebus L.A., Panetta J.A. The antioxidant LY231617 reduces global ischemic neuronal injury in rats. Stroke. 24:1993;716-723.
    • (1993) Stroke , vol.24 , pp. 716-723
    • Clemens, J.A.1    Saunders, R.D.2    Ho, P.P.3    Phebus, L.A.4    Panetta, J.A.5
  • 13
    • 0032961726 scopus 로고    scopus 로고
    • A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat
    • Coert B.A., Anderson R.E., Meyer F.B. A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat. J. Neurosurg. 90:1999;232-338.
    • (1999) J. Neurosurg. , vol.90 , pp. 232-338
    • Coert, B.A.1    Anderson, R.E.2    Meyer, F.B.3
  • 14
    • 0028674890 scopus 로고
    • Nitric oxide, focal cerebral ischemia: Multiplicity of actions and diverse outcomes
    • Dawson D.A. Nitric oxide, focal cerebral ischemia: multiplicity of actions and diverse outcomes. Cerebrovasc. Brain Metab. Rev. 6:1995;299-324.
    • (1995) Cerebrovasc. Brain Metab. Rev. , vol.6 , pp. 299-324
    • Dawson, D.A.1
  • 15
    • 0028064463 scopus 로고
    • Anti-ischaemic efficacy of a nitric oxide synthase inhibitor and a N-methyl-D-aspartate receptor antagonist in models of transient and permanent focal cerebral ischaemia
    • Dawson D.A., Graham D.I., McCulloch J., Macrae I.M. Anti-ischaemic efficacy of a nitric oxide synthase inhibitor and a N-methyl-D-aspartate receptor antagonist in models of transient and permanent focal cerebral ischaemia. Br. J. Pharmacol. 113:1994;247-253.
    • (1994) Br. J. Pharmacol. , vol.113 , pp. 247-253
    • Dawson, D.A.1    Graham, D.I.2    McCulloch, J.3    MacRae, I.M.4
  • 16
    • 0029927787 scopus 로고    scopus 로고
    • Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice
    • Dawson V.L., Kizushi V.M., Huang P.L., Snyder S.H., Dawson T.M. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J. Neurosci. 16:1996;2479-2487.
    • (1996) J. Neurosci. , vol.16 , pp. 2479-2487
    • Dawson, V.L.1    Kizushi, V.M.2    Huang, P.L.3    Snyder, S.H.4    Dawson, T.M.5
  • 17
    • 0031940409 scopus 로고    scopus 로고
    • Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl) imidazole and 7-nitroindazole after focal cerebral ischemia in the rat
    • Escott K.J., Beech J.S., Haga K.K., Williams S.C., Meldrum B.S., Bath P.M. Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl) imidazole and 7-nitroindazole after focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab. 18:1998;281-287.
    • (1998) J. Cereb. Blood Flow Metab. , vol.18 , pp. 281-287
    • Escott, K.J.1    Beech, J.S.2    Haga, K.K.3    Williams, S.C.4    Meldrum, B.S.5    Bath, P.M.6
  • 18
    • 0024462440 scopus 로고
    • NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices
    • Garthwaite J., Garthwaite G., Palmer R.M.J., Moncada S. NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur. J. Pharmacol. 172:1989;413-416.
    • (1989) Eur. J. Pharmacol. , vol.172 , pp. 413-416
    • Garthwaite, J.1    Garthwaite, G.2    Palmer, R.M.J.3    Moncada, S.4
  • 19
    • 0033028770 scopus 로고    scopus 로고
    • Nitric oxide: From basic research to clinical application
    • Green I.C., Chabrier P.-E. Nitric oxide: from basic research to clinical application. Drug Discov. Today. 4:1999;47-49.
    • (1999) Drug Discov. Today , vol.4 , pp. 47-49
    • Green, I.C.1    Chabrier, P.-E.2
  • 20
    • 0034862894 scopus 로고    scopus 로고
    • Diffusion weighted MRI detects early neuropathology following four vessel occlusion ischaemia in the rat
    • Gregory L.J., O'Neill M.J., Nunn J.A., Gray J.A., Williams S.C.R. Diffusion weighted MRI detects early neuropathology following four vessel occlusion ischaemia in the rat. J. Magn. Reson. Imaging. 14:2001;207-214.
    • (2001) J. Magn. Reson. Imaging , vol.14 , pp. 207-214
    • Gregory, L.J.1    O'Neill, M.J.2    Nunn, J.A.3    Gray, J.A.4    Williams, S.C.R.5
  • 21
    • 0024589421 scopus 로고
    • Central nervous system trauma and stroke: II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation
    • Hall E.D., Braughler J.M. Central nervous system trauma and stroke: II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radic. Biol. Med. 6:1989;303-313.
    • (1989) Free Radic. Biol. Med. , vol.6 , pp. 303-313
    • Hall, E.D.1    Braughler, J.M.2
  • 22
    • 0028823098 scopus 로고
    • The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse
    • Handy R.L.C., Wallace P., Gaffen Z.A., Whitehead K.J., Moore P.K. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br. J. Pharmacol. 116:1995;2349-2350.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2349-2350
    • Handy, R.L.C.1    Wallace, P.2    Gaffen, Z.A.3    Whitehead, K.J.4    Moore, P.K.5
  • 23
    • 0029793223 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: Antinociceptive and cardiovascular effects
    • Handy R.L.C., Harb H.L., Wallace P., Gaffen Z.A., Whitehead K.J., Moore P.K. Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br. J. Pharmacol. 119:1996;423-431.
    • (1996) Br. J. Pharmacol. , vol.119 , pp. 423-431
    • Handy, R.L.C.1    Harb, H.L.2    Wallace, P.3    Gaffen, Z.A.4    Whitehead, K.J.5    Moore, P.K.6
  • 24
    • 0032732371 scopus 로고    scopus 로고
    • Effect of AR-R 17477, a potent neuronal nitric oxide synthase inhibitor, on infarction volume resulting from permanent focal ischaemia in rats
    • Harukuni I., Traystman R.J., Kirsch J.R. Effect of AR-R 17477, a potent neuronal nitric oxide synthase inhibitor, on infarction volume resulting from permanent focal ischaemia in rats. Crit. Care Med. 27:1999;2508-2511.
    • (1999) Crit. Care Med. , vol.27 , pp. 2508-2511
    • Harukuni, I.1    Traystman, R.J.2    Kirsch, J.R.3
  • 25
    • 0027945658 scopus 로고
    • Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
    • Huang Z., Huang P.L., Panahian N., Dalkara T., Fishman M.C., Moskowitz M.A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 265:1994;1883-1885.
    • (1994) Science , vol.265 , pp. 1883-1885
    • Huang, Z.1    Huang, P.L.2    Panahian, N.3    Dalkara, T.4    Fishman, M.C.5    Moskowitz, M.A.6
  • 29
    • 0030066061 scopus 로고    scopus 로고
    • Reduction of the neurological deficit in mice with traumatic brain injury by nitric oxide synthase inhibitors
    • Mésenge C., Verrecchia C., Allix M., Boulu R.G., Plotkine M. Reduction of the neurological deficit in mice with traumatic brain injury by nitric oxide synthase inhibitors. J. Neurotrauma. 13:1996;209-214.
    • (1996) J. Neurotrauma , vol.13 , pp. 209-214
    • Mésenge, C.1    Verrecchia, C.2    Allix, M.3    Boulu, R.G.4    Plotkine, M.5
  • 30
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology and pharmacology
    • Moncada S., Plamer R.M.J., Higgs E.A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43:1991;109-142.
    • (1991) Pharmacol. Rev. , vol.43 , pp. 109-142
    • Moncada, S.1    Plamer, R.M.J.2    Higgs, E.A.3
  • 31
    • 0030795934 scopus 로고    scopus 로고
    • Selective inhibitors of neuronal nitric oxide synthase - Is no NOS really good NOS for the nervous system?
    • Moore P.K., Handy R.L.C. Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? Trends Pharmacol. Sci. 18:1997;204-211.
    • (1997) Trends Pharmacol. Sci. , vol.18 , pp. 204-211
    • Moore, P.K.1    Handy, R.L.C.2
  • 32
    • 0028851986 scopus 로고
    • Nitric oxide synthase in?: Possible contribution of nitric oxide synthase activation in brain microvessels to cerebral ischemic injury
    • Nagafuji T., Sugiyama M., Makino T., Muto A., Naito S. Nitric oxide synthase in?: possible contribution of nitric oxide synthase activation in brain microvessels to cerebral ischemic injury. Mol. Chem. Neuropathol. 26:1995;107-155.
    • (1995) Mol. Chem. Neuropathol. , vol.26 , pp. 107-155
    • Nagafuji, T.1    Sugiyama, M.2    Makino, T.3    Muto, A.4    Naito, S.5
  • 33
    • 0025940118 scopus 로고
    • Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse
    • Nowicki J.P., Duval D., Poignet H., Scatton B. Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. Eur. J. Pharmacol. 204:1991;339-340.
    • (1991) Eur. J. Pharmacol. , vol.204 , pp. 339-340
    • Nowicki, J.P.1    Duval, D.2    Poignet, H.3    Scatton, B.4
  • 35
    • 0030605974 scopus 로고    scopus 로고
    • Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia
    • O'Neill M.J., Hicks C., Ward M. Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia. Eur. J. Pharmacol. 310:1996;115-122.
    • (1996) Eur. J. Pharmacol. , vol.310 , pp. 115-122
    • O'Neill, M.J.1    Hicks, C.2    Ward, M.3
  • 36
    • 0030806308 scopus 로고    scopus 로고
    • Neuroprotective effects of the antioxidant LY231617 and neuronal NO synthase inhibitors in global cerebral ischaemia
    • O'Neill M.J., Hicks C.A., Ward M.A., Panetta J.A. Neuroprotective effects of the antioxidant LY231617 and neuronal NO synthase inhibitors in global cerebral ischaemia. Brain Res. 760:1997;170-178.
    • (1997) Brain Res. , vol.760 , pp. 170-178
    • O'Neill, M.J.1    Hicks, C.A.2    Ward, M.A.3    Panetta, J.A.4
  • 40
    • 0018347695 scopus 로고
    • A new model of bilateral hemispheric ischemia in the unanesthetized rat
    • Pulsinelli W.A., Brierley J.B. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke. 10:1979;267-272.
    • (1979) Stroke , vol.10 , pp. 267-272
    • Pulsinelli, W.A.1    Brierley, J.B.2
  • 41
  • 42
    • 0026777223 scopus 로고
    • Pathophysiology and treatment of focal cerebral ischemia: Part I. Pathophysiology
    • Siesjö B.K. Pathophysiology and treatment of focal cerebral ischemia: Part I. Pathophysiology. J. Neurosurg. 77:1992;169-184.
    • (1992) J. Neurosurg. , vol.77 , pp. 169-184
    • Siesjö, B.K.1
  • 43
    • 0032472217 scopus 로고    scopus 로고
    • Consecutive evaluation of nitric oxide production after transient cerebral ischemia in the rat hippocampus using in vivo brain microdialysis
    • Togashi H., Mori K., Ueno K.I., Matsumoto M., Suda N., Saito H., Yoshioka M. Consecutive evaluation of nitric oxide production after transient cerebral ischemia in the rat hippocampus using in vivo brain microdialysis. Neurosci. Lett. 240:1998;53-57.
    • (1998) Neurosci. Lett. , vol.240 , pp. 53-57
    • Togashi, H.1    Mori, K.2    Ueno, K.I.3    Matsumoto, M.4    Suda, N.5    Saito, H.6    Yoshioka, M.7
  • 44
    • 0026008909 scopus 로고
    • Oxygen radical mechanisms of brain injury following ischemia and reperfusion
    • Traystman R.J., Kirsch J.R., Koehler R.C. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J. Appl. Physiol. 71:1991;1185-1195.
    • (1991) J. Appl. Physiol. , vol.71 , pp. 1185-1195
    • Traystman, R.J.1    Kirsch, J.R.2    Koehler, R.C.3
  • 45
    • 0031732993 scopus 로고    scopus 로고
    • Role of nitric oxide in traumatic brain injury in the rat
    • Wada K., Chatzipanteli K., Buto R., Dietrich W.D. Role of nitric oxide in traumatic brain injury in the rat. J. Neurosurg. 89:1998;807-818.
    • (1998) J. Neurosurg. , vol.89 , pp. 807-818
    • Wada, K.1    Chatzipanteli, K.2    Buto, R.3    Dietrich, W.D.4
  • 46
    • 0033035867 scopus 로고    scopus 로고
    • Effects of L-NAME and 7-NI on NOS catalytic activity and behavioral outcome after traumatic brain injury in the rat
    • Wada K., Chatzipanteli K., Buto R., Dietrich W.D. Effects of L-NAME and 7-NI on NOS catalytic activity and behavioral outcome after traumatic brain injury in the rat. J. Neurotrauma. 16:1999;203-212.
    • (1999) J. Neurotrauma , vol.16 , pp. 203-212
    • Wada, K.1    Chatzipanteli, K.2    Buto, R.3    Dietrich, W.D.4
  • 47
    • 0032782417 scopus 로고    scopus 로고
    • Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia
    • Wei G., Dawson V.L., Zweier J.L. Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia. Biochim. Biophys. Acta. 1455:1999;23-34.
    • (1999) Biochim. Biophys. Acta , vol.1455 , pp. 23-34
    • Wei, G.1    Dawson, V.L.2    Zweier, J.L.3
  • 48
    • 0027942138 scopus 로고
    • The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not response to topical acetylcholine in pial vessels
    • Yoshida T., Limmroth V., Irikura K., Moskowitz M.A. The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not response to topical acetylcholine in pial vessels. J. Cereb. Blood Flow Metab. 14:1994;924-929.
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 924-929
    • Yoshida, T.1    Limmroth, V.2    Irikura, K.3    Moskowitz, M.A.4
  • 49
    • 0029046959 scopus 로고
    • Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion
    • Yoshida T., Waeber C., Huang Z., Moskowitz M.A. Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion. Neurosci. Lett. 194:1995;214-218.
    • (1995) Neurosci. Lett. , vol.194 , pp. 214-218
    • Yoshida, T.1    Waeber, C.2    Huang, Z.3    Moskowitz, M.A.4
  • 50
    • 0024494427 scopus 로고
    • Reversible middle cerebral artery occlusion without craniectomy in rats
    • Zea Longa E., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:1989;84-91.
    • (1989) Stroke , vol.20 , pp. 84-91
    • Zea Longa, E.1    Weinstein, P.R.2    Carlson, S.3    Cummins, R.4
  • 51
    • 0029670958 scopus 로고    scopus 로고
    • Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion
    • Zhang F., Casey R.M., Ross M.E., Iadecola C. Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion. Stroke. 27:1996;317-323.
    • (1996) Stroke , vol.27 , pp. 317-323
    • Zhang, F.1    Casey, R.M.2    Ross, M.E.3    Iadecola, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.