The effect of carbapenem antibiotics on plasma concentrations of valproic acid

Annals of Pharmacotherapy

Volumn 43, Issue 12, 2009, Pages 2082-2087

  Mancl, Erin E ^a   Gidal, Barry E ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Carbapenem; Drug interactions; Pharmacokinetics; Valproic acid

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; BETA GLUCURONIDASE; CARBAPENEM; DORIPENEM; GLUCURONIC ACID; GLUCURONIDE; IMIPENEM; INDOMETACIN; MEROPENEM; MULTIDRUG RESISTANCE PROTEIN; PANIPENEM; URIDINE DIPHOSPHATE; VALPROATE SEMISODIUM; VALPROIC ACID;

ANTIMICROBIAL ACTIVITY; AREA UNDER THE CURVE; BASOLATERAL MEMBRANE; CELL STRAIN CACO 2; CELLULAR DISTRIBUTION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG GLUCURONIDATION; DRUG INHIBITION; DRUG MECHANISM; DRUG METABOLISM; DRUG TRANSFORMATION; DRUG TRANSPORT; DRUG UPTAKE; ENTEROHEPATIC CIRCULATION; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; FOLLOW UP; HUMAN; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE FLORA; NONHUMAN; PRIORITY JOURNAL; RABBIT; REVIEW;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; ANTICONVULSANTS; BIOLOGICAL TRANSPORT; CARBAPENEMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG MONITORING; HUMANS; RABBITS; RATS; TISSUE DISTRIBUTION; VALPROIC ACID;

EID: 72249112714     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1M296     Document Type: Review

References (27)

1. Gidal BE, French JA, Grossman P, Le Teuff G. Assessment of potential drug interactions in patients with epilepsy: impact of age and sex. Neurology 2009;72:419-425 DOI 10.1212/01.wnl.0000341789.77291.8d
2. French JA, Pedley TA. Initial management of epilepsy. N Engl J Med 2008;359;166-176 DOI 10.1056/NEJMcp0801738
3. Fudio S, Carcas A, Pinana E, Ortega R. Epileptic seizures caused by low valproic acid levels from an interaction with meropenem. J Clin Pharm Ther 2006;31:393-396 DOI 10.1111/j.1365-2710.2006.00743.x (Pubitemid 44060205)
4. Coves-Orts FJ, Borras-Blasco J, Navarro-Ruiz A, et al. Acute seizures due to a probable interaction between valproic acid and meropenem. Ann Pharmacother 2005;39:533-537 DOI 10.1345/aph.1E358 (Pubitemid 40270921)
5. Nacarkucuk E, Saglam H, Okan M. Meropenem decreases serum level of valproic acid. Pediatr Neurol 2004;31:232-234 DOI 10.1016/j.pediatrneurol.2004. 03.014 (Pubitemid 39221255)
6. Nagai K, Shimizu T, Togo A, et al. Decrease in serum levels of valproic acid during treatment with a new carbapenem, panipenem/betamipron. J Antimicrob Chemother 1997;39:295-296 DOI 10.1093/jac/39.2.295 (Pubitemid 27116436)
7. Lunde JL, Nelson RE, Storandt HF. Acute seizures in a patient receiving divalproex sodium after starting ertapenem therapy. Pharmacotherapy 2007;27:1202-1205 DOI 10.1592/phco.27.8.1202
8. Welfare Ministry of Japan. Adverse reactions of drugs. Welfare Ministry of Japan. 1996; no.137.
9. Product information. Depakote (valproic acid). Chicago, IL: Abbott Laboratories, April 2009.
10. Su SF, Huang JD. Inhibition of the intestinal digoxin absorption and exsorption by quinidine. Drug Metab Dispos 1996;24:142-147 (Pubitemid 26063903)
11. Torii M, Takiguchi Y, Saito F, Izumi M, Yokota M. Inhibition by carbapenem antibiotic imipenem of intestinal absorption of valproic acid in rats. J Pharm Pharmacol 2001;53:823-829 DOI 10.1211/0022357011776171 (Pubitemid 32529725)
12. Torii M, Takiguchi Y, Izumi M, Fukushima T, Yokota M. Carbapenem antibiotics inhibit valproic acid transport in caco-2 cell monolayers. Int J Pharm 2002;233:253-256 DOI 10.1016/S0378-5173(01)00916-4 (Pubitemid 34230437)
13. Semmes RL, Shen DD. A reversible clearance model for the enterohepatic circulation of drug and conjugate metabolite pair. Drug Metab Dispos 1990;18:80-87
14. Yokogawa K, Iwashita S, Kubota A, et al. Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits. Pharm Res 2001;18:1320-1326 (Pubitemid 32846327)
15. Nakajima Y, Mizobuchi M, Nakamura M, et al. Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats. Drug Metab Dispos 2004;32:1383-1391 DOI 10.1124/dmd.104.000661 (Pubitemid 39564558)
16. Hawkesworth G, Draser B, Hill MJ. Intestinal bacteria and the hydrolysis of glycosidic bonds. J Med Microbiol 1971;4:451-459
17. McBain AJ, Macfarlane GT. Ecological and physiological studies on large intestinal bacteria in relation to production of hydrolytic and reductive enzymes involved in formation of genotoxic metabolites. J Med Microbiol 1998;47:407-416
18. Akao T. Competition in the metabolism of glycyrrhizin with glycyrrhetic acid mono-glucuronide by mixed Eubacterium sp. GLH and Ruminococcus sp. PO1-3. Biol Pharm Bull 2000;23:149-154 (Pubitemid 30136971)
19. Livaoglu M, Yilmaz G, Kerimoglu S, Aydin K, Karacal N. Necrotizing fasciitis with ruminococcus. J Med Microbiol 2008;57:246-248 DOI 10.1099/jmm.0.47453-0
20. Driessen O, Treuen L, Meijer JWA. Distribution of drugs over whole blood: I. the transport function of whole blood for valproate. Ther Drug Monit 1989;11:384-389 (Pubitemid 19157196)
21. Omoda K, Muakami T, Yumoto R, et al. Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human. J Pharm Sci 2005;94:1685-1693 DOI 10.1002/jps.20338 (Pubitemid 41360863)
22. Ogawa K, Yumoto R, Hamada N, Nagai J, Takano M. Interaction of valproic acid and carbapenem antibiotics with multidrug-resistance-associated proteins in rat erythrocyte membranes. Epilepsy Res 2006;71:76-87. DOI 10.1016/j. eplepsyres.2006.05.016 (Pubitemid 44233201)
23. Cornford EM, Landon KP. Blood-brain transport of CI-912: single-passage equilibrium of erythrocyte-borne drug. Ther Drug Monit 1985;7:247-254
24. Ethell BT, Anderson GD, Burchell B. The effect of valproic acid on drug and steroid glucuronidation by expressed human UDP-glucuronosyltransferases. Biochem Pharmacol 2003;65:1441-1449 DOI 10.1016/S0006-2952(03)00076-5 (Pubitemid 36555832)
25. Green MD, Tephly TR. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein. Drug Metab Dispos 1996;24:356-363
26. Green MD, King CD, Mojarrabi B, Mackenzie PI, Tephly TR. Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos 1998;26:507-512 (Pubitemid 28498354)
27. Yamamura N, Imura-Miyoshi K, Naganuma H. Panipenem, a carbapenem antibiotic, increases the level of hepatic UDP-glucuronic acid in rats. Drug Metab Dispos 2000;28:1484-1486