4-oxospiro[benzopyran-2,4'-piperidines] as selective α(1a)-adrenergic receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 2, 1999, Pages 291-294

  Nerenberg, Jennie B ^a   Erb, Jill M ^a   Bergman, Jeffrey M ^a   O'Malley, Stacey ^a   Chang, Raymond S L ^a   Scott, Ann L ^a   Broten, Theodore P ^a   Bock, Mark G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ANTIARRHYTHMIC AGENT; BENZOPYRAN DERIVATIVE; PIPERIDINE DERIVATIVE; RECEPTOR SUBTYPE;

ANIMAL CELL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; FERRET; HEART MUSCLE REFRACTORY PERIOD; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BENZOPYRANS; HUMANS; MALE; PIPERIDINES; PROSTATIC HYPERPLASIA; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; SPIRO COMPOUNDS;

ANIMALIA; MUSTELA PUTORIUS FURO;

EID: 0033579853     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00732-X     Document Type: Article

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18. The optimum chain length linking the naphthyl and 4-oxospiro[benzopyran-2,4'-piperidine] rings was determined to be two carbon atoms.