From imide to lactam metallo-pyridocarbazoles: Distinct scaffolds for the design of selective protein kinase inhibitors

Journal of Organic Chemistry

Volumn 74, Issue 23, 2009, Pages 8997-9009

  Pagano, Nicholas ^a,b   Wong, Eric Y ^b   Breiding, Tom ^a   Liu, Haidong ^a,c   Wilbuer, Alexander ^a   Bregman, Howard ^b   Diamond, Scott L ^b   Meggers, Eric ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-BINDING SITE; BIOLOGICAL PROPERTIES; CHEMICAL EQUATIONS; HALF-SANDWICH COMPLEXES; LEAD STRUCTURE; MALEIMIDES; MODEL SYSTEM; PHARMACOPHORES; PROTEIN KINASE; PROTEIN KINASE INHIBITORS; SELECTIVE INHIBITORS;

BINDING ENERGY; BINDING SITES; CHEMICAL REACTIONS; HYDROGEN BONDS; METAL COMPLEXES; ORGANOMETALLICS; PROTEINS; RUTHENIUM; RUTHENIUM COMPOUNDS; SCAFFOLDS;

STRUCTURAL DESIGN;

CARBAZOLE DERIVATIVE; CLK 2 PROTEIN; GLYCOGEN SYNTHASE KINASE; IMIDE; LACTAM DERIVATIVE; LACTAM METALLOPYRIDOCARBAZOLE; LEAD; METAL COMPLEX; ORGANOMETALLIC COMPOUND; PROTEIN KINASE INHIBITOR; PROTEIN KINASE PIM 1; PROTEIN TYROSINE KINASE A; RUTHENIUM; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ISOMER; PHARMACOPHORE;

CARBAZOLES; DRUG DESIGN; HUMANS; IMIDES; LACTAMS; METALS; ORGANOMETALLIC COMPOUNDS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PYRIDONES; RECEPTOR, TRKA; RUTHENIUM;

EID: 72249107516     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo901641k     Document Type: Article

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