Genetic variants of IL-6 and its receptor are not associated with schizophrenia in Taiwan

Neuroscience Letters

Volumn 468, Issue 3, 2010, Pages 330-333

  Liu, Yu Li ^a,b   Liu, Chih Min ^b   Fann, Cathy Shen Jang ^c   Yang, Wei Chih ^c   Chen, Ya Hui ^b   Tseng, Li Jung ^b   Liu, Shih Kai ^b   Hsieh, Ming H ^b   Hwang, Tzung Jeng ^b   Chan, Hung Yu ^d   Chen, Jiann Jyh ^d   Chen, Wei J ^e   Hwu, Hai Gwo ^b,e  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^d Taoyuan Psychiatric Center   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

IL 6; IL 6 receptor; RFLP; Schizophrenia; Tetra primer ARMS

Indexed keywords

DINUCLEOTIDE; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; TRINUCLEOTIDE;

3' UNTRANSLATED REGION; ADULT; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; ENZYME REGULATION; EXON; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; PHENOTYPE; POSITIVE SYNDROME; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; TAIWAN;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-6; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-6; SCHIZOPHRENIA; TAIWAN;

EID: 72249102808     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.11.026     Document Type: Article

References (27)

1. Akiyama K. Serum levels of soluble IL-2 receptor alpha, IL-6 and IL-1 receptor antagonist in schizophrenia before and during neuroleptic administration. Schizophr. Res. 37 (1999) 97-106
2. American Psychiatric Association, Diagnostic and Statistical Manual, American Psychiatric Press, Washington, DC, 1994.
3. Andreasen N. The Scale for Assessment of Positive Symptoms (SAPS) (1984), University of Iowa, Iowa City, IA
4. Andreasen N. The Scale for the Assessment of Negative Symptoms (SANS) (1983), University of Iowa, Iowa City, IA
5. Aukes M.F., Alizadeh B.Z., Sitskoorn M.M., Kemner C., Ophoff R.A., and Kahn R.S. Genetic overlap among intelligence and other candidate endophenotypes for schizophrenia. Biol. Psychiatry 65 (2009) 527-534
6. Buka S.L., Tsuang M.T., Torrey E.F., Klebanoff M.A., Wagner R.L., and Yolken R.H. Maternal cytokine levels during pregnancy and adult psychosis. Brain Behav. Immun. 15 (2001) 411-420
7. Chen W.J., Liu S.K., Chang C.J., Lien Y.J., Chang Y.H., and Hwu H.G. Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. Am. J. Psychiatry 155 (1998) 1214-1220
8. Chowdari K.V., Mirnics K., Semwal P., Wood J., Lawrence E., Bhatia T., Deshpande S.N., Ferrell K.T.B.R.E., Middleton F.A., Devlin B., Levitt P., Lewis D.A., and Nimgaonkar V.L. Association and linkage analyses of RGS4 polymorphisms in schizophrenia. Hum. Mol. Genet. 11 (2002) 1373-1380
9. Erbagci A.B., Herken H., Koyluoglu O., Yilmaz N., and Tarakcioglu M. Serum IL-1beta, sIL-2R, IL-6, IL-8 and TNF-alpha in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment. Mediators Inflamm. 10 (2001) 109-115
10. Freedman R., Leonard S., Olincy A., Kaufmann C.A., Malaspina D., Cloninger C.R., Svrakic D., Faraone S.V., and Tsuang M.T. Evidence for the multigenic inheritance of schizophrenia. Am. J. Med. Genet. 105 (2001) 794-800
11. Frommberger U.H., Bauer J., Haselbauer P., Fraulin A., Riemann D., and Berger M. Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission. Eur. Arch. Psychiatry Clin. Neurosci. 247 (1997) 228-233
12. Gabriel S.B., Schaffner S.F., Nguyen H., Moore J.M., Roy J., Blumenstiel B., Higgins J., DeFelice M., Lochner A., Faggart M., Liu-Cordero S.N., Rotimi C., Adeyemo A., Cooper R., Ward R., Lander E.S., Daly M.J., and Altshuler D. The structure of haplotype blocks in the human genome. Science 296 (2002) 2225-2229
13. Galicia J.C., Tai H., Komatsu Y., Shimada Y., Akazawa K., and Yoshie H. Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced. Genes Immun. 5 (2004) 513-516
14. Garver D.L., Tamas R.L., and Holcomb J.A. Elevated interleukin-6 in the cerebrospinal fluid of a previously delineated schizophrenia subtype. Neuropsychopharmacology 28 (2003) 1515-1520
15. Kaminska T., Szuster-Ciesielska A., Wysocka A., Marmurowska-Michalowska H., Dubas-Slemp H., and Kandefer-Szerszen M. Serum cytokine level and production of reactive oxygen species (ROS) by blood neutrophils from a schizophrenic patient with hypersensitivity to neuroleptics. Med. Sci. Monit. 9 (2003) CS71-CS75
16. MacDonald III A.W., Pogue-Geile M.F., Debski T.T., and Manuck S. Genetic and environmental influences on schizotypy: a community-based twin study. Schizophr. Bull. 27 (2001) 47-58
17. Muller-Newen G., Kuster A., Hemmann U., Keul R., Horsten U., Martens A., Graeve L., Wijdenes J., and Heinrich P.C. Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses. J. Immunol. 161 (1998) 6347-6355
18. Muller N., Riedel M., Gruber R., Ackenheil M., and Schwarz M.J. The immune system and schizophrenia. An integrative view. Ann. N. Y. Acad. Sci. 917 (2000) 456-467
19. Naudin J., Mege J.L., Azorin J.M., and Dassa D. Elevated circulating levels of IL-6 in schizophrenia. Schizophr. Res. 20 (1996) 269-273
20. Nuechterlein K.H. Vigilance in schizophrenia and related disorders. In: Zubin J. (Ed). Handbook of Schizophrenia. Vol.5. Neuropsychology, Psychophysiology and Information Processing (1991), Elsevier, Amsterdam 397-433
21. Potvin S., Stip E., Sepehry A.A., Gendron A., Bah R., and Kouassi E. Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol. Psychiatry 63 (2008) 801-808
22. Strous R.D., and Shoenfeld Y. Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited. J. Autoimmun. 27 (2006) 71-80
23. Sun S., Wang F., Wei J., Cao L.Y., Qi L.Y., Xiu M.H., Chen S., Li X.H., Kosten T.A., Kosten T.R., and Zhang X.Y. Association between interleukin-6 receptor polymorphism and patients with schizophrenia. Schizophr. Res. 102 (2008) 346-347
24. van Kammen D.P., McAllister-Sistilli C.G., Kelley M.E., Gurklis J.A., and Yao J.K. Elevated interleukin-6 in schizophrenia. Psychiatry Res. 87 (1999) 129-136
25. Ye S., Dhillon S., Ke X., Collins A.R., and Day I.N. An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res. 29 (2001) E88-E188
26. Zhang X.Y., Zhou D.F., Zhang P.Y., Wu G.Y., Cao L.Y., and Shen Y.C. Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Schizophr. Res. 57 (2002) 247-258
27. Zhao B., and Schwartz J.P. Involvement of cytokines in normal CNS development and neurological diseases: recent progress and perspectives. J. Neurosci. Res. 52 (1998) 7-16