A model of Na+/H+ exchanger and its central role in regulation of pH and Na+ in cardiac myocytes

Biophysical Journal

Volumn 97, Issue 10, 2009, Pages 2674-2683

  Cha, Chae Young ^a,b   Oka, Chiaki ^b   Earm, Yung E ^c   Wakabayashi, Shigeo ^d   Noma, Akinori ^a  

^a RITSUMEIKAN UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Seoul National University   (South Korea)

^d NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); HYDROGEN; SODIUM PROTON EXCHANGE PROTEIN;

ACIDIFICATION; ARTICLE; CELL SURVIVAL; HEART MUSCLE CELL; HOMEOSTASIS; ION CURRENT; KINETICS; PH; SODIUM CURRENT;

EID: 72149127694     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.08.053     Document Type: Article

References (47)

1. Leem, C. H., D. Lagadic-Gossmann, and R. D. Vaughan-Jones. 1999. Characterization of intracellular pH regulation in the guinea-pig ventricular myocyte. J. Physiol. 517:159-180.
2. 3- cotransport in ventricular myocytes from rat, rabbit and guinea pig. J. Physiol. 562:455-475.
3. +-HCO co-transport. J. Cardiovasc. Electrophysiol. 17 (Suppl 1):S134-S140.
4. + exchange blockers EIPA, cariporide and eniporide. Mol. Cell. Biochem. 250:47-54.
5. +-overload in ischemia and is cardioprotective. J. Mol. Cell. Cardiol. 31:1985-1995.
6. + exchanger in the slow force response to myocardial stretch. Circ. Res. 85:658-660.
7. Cingolani, H. E., N. G. Perez, E. A. Aiello, and M. C. de Hurtado. 2005. Intracellular signaling following myocardial stretch: an autocrine/paracrine loop. Regul. Pept. 128:211-220.
8. Crampin, E. J., N. P. Smith, A. E. Langham, R. H. Clayton, and C. H. Orchard. 2006. Acidosis in models of cardiac ventricular myocytes. Philos. Transact. A Math. Phys. Eng. Sci. 364:1171-1186.
9. Ch'en, F. F., R. D. Vaughan-Jones, K. Clarke, and D. Noble. 1998. Modeling myocardial ischemia and reperfusion. Prog. Biophys. Mol. Biol. 69:515-538.
10. Swietach, P., and R. D. Vaughan-Jones. 2005. Spatial regulation of intracellular pH in the ventricular myocyte. Ann. N.Y. Acad. Sci. 1047:271-282.
11. + exchanger, NHE3. J. Biol. Chem. 282:7376-7384.
12. + antiporter within a mathematical model of the rat proximal tubule. J. Gen. Physiol. 105:617-641.
13. Crampin, E. J., and N. P. Smith. 2006. A dynamic model of excitation-contraction coupling during acidosis in cardiac ventricular myocytes. Biophys. J. 90:3074-3090.
14. Niederer, S. A., and N. P. Smith. 2007. A mathematical model of the slow force response to stretch in rat ventricular myocytes. Biophys. J. 92:4030-4044.
15. + exchangers by measurement of reverse mode reaction. J. Biol. Chem. 278:43580-43585.
16. + exchanger isoform 1 overproduced in Saccharomyces cerevisiae. J. Biol. Chem. 283:4145-4154.
17. + exchange. Proc. Natl. Acad. Sci. USA. 86:4818-4822.
18. + exchanger in the pre-steady state. Implications for the exchange mechanism. J. Biol. Chem. 268:3184-3193.
19. Lacroix, J., M. Poet, C. Maehrel, and L. Counillon. 2004. A mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogens. EMBO Rep. 5:91-96. (Pubitemid 38228534)
20. Fuster, D., O. W. Moe, and D. W. Hilgemann. 2008. Steady-state function of the ubiquitous mammalian Na/H exchanger (NHE1) in relation to dimer couplingmodelswith 2Na/2Hstoichiometry. J. Gen. Physiol. 132:465-480.
21. + exchange in the sheep cardiac Purkinje fiber. J. Physiol. 428:441-466.
22. + ions on Na-H exchange in sheep cardiac Purkinje fibers. J. Mol. Cell. Cardiol. 29:1131-1140.
23. + exchanger. Annu. Rev. Physiol. 47:545-560.
24. + exchanger. J. Gen. Physiol. 92:239-261.
25. + exchange in isolated myocytes from adult rat heart. Am. J. Physiol. 257:C207-C213.
26. van Borren, M. M., A. Baartscheer, R. Wilders, and J. H. Ravesloot. 2004. NHE-1 and NBC during pseudo-ischemia/reperfusion in rabbit ventricular myocytes. J. Mol. Cell. Cardiol. 37:567-577.
27. + exchange system in rat brain synaptosomes. Interdependence of internal and external pH control of the exchange activity. J. Biol. Chem. 260:9678-9684.
28. Bountra, C., T. Powell, and R. D. Vaughan-Jones. 1990. Comparison of intracellular pH transients in single ventricular myocytes and isolated ventricular muscle of guinea-pig. J. Physiol. 424:343-365. (Pubitemid 20175162)
29. + exchanger NHE1 in rat myocardium. Am. J. Physiol. 276:H709-H717.
30. + exchange in vascular smooth muscle cells from WKY and SHR: effects of phorbol ester. Am. J. Physiol. 268:C14-C20.
31. + antiporter phenotype and turnover of immortalized lymphoblasts from type 1 diabetic patients with nephropathy. J. Clin. Invest. 93:2750-2757.
32. + antiporter in normal and transformed human lymphocytes and fibroblasts. Am. J. Physiol. 267:C745-C752.
33. + buffering power in the sheep cardiac Purkinje fiber. J. Physiol. 425:429-448.
34. Sun, B., C. H. Leem, and R. D. Vaughan-Jones. 1996. Novel chloride-dependent acid loader in the guinea-pig ventricular myocyte: part of a dual acid-loading mechanism. J. Physiol. 495:65-82. (Pubitemid 26288454)
35. Niederer, S.A., P. Swietach, D.A.Wilson, N. P. Smith, and R. D. Vaughan- Jones. 2008. Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte. Biophys. J. 94:2385-2403.
36. Matsuoka, S., N. Sarai, S. Kuratomi, K. Ono, and A. Noma. 2003. Role of individual ionic current systems in ventricular cells hypothesized by a model study. Jpn. J. Physiol. 53:105-123.
37. + channel in guinea pig ventricular myocytes. J. Membr. Biol. 122:33-42.
38. + pump current on external monovalent cations and membrane potential in rabbit cardiac Purkinje cells. J. Physiol. 442:169-189.
39. Vaughan-Jones, R. D., and K. W. Spitzer. 2002. Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte. Biochem. Cell Biol. 80:579-596.
40. Deitmer, J. W., and D. Ellis. 1980. Interactions between the regulation of the intracellular pH and sodium activity of sheep cardiac Purkinje fibers. J. Physiol. 304:471-488. (Pubitemid 10034395)
41. + ions can affect intracellular pH in mammalian cardiac muscle. Nature. 301:522-524.
42. Kaila, K., and R. D. Vaughan-Jones. 1987. Influence of sodium-hydrogen exchange on intracellular pH, sodium and tension in sheep cardiac Purkinje fibers. J. Physiol. 390:93-118. (Pubitemid 17147848)
43. Levi, A. J. 1991. The effect of strophanthidin on action potential, calcium current and contraction in isolated guinea-pig ventricular myocytes. J. Physiol. 443:1-23.
44. Blaustein, M. P., and W. J. Lederer. 1999. Sodium/calcium exchange: its physiological implications. Physiol. Rev. 79:763-854.
45. +-exchanger in the heart. Curr. Vasc. Pharmacol. 4:23-29.
46. 3, and metabolic inhibitors. J. Gen. Physiol. 67:91-112.
47. 4+ transport in HeLa cells. Pflugers Arch. 450:155-167.