Expression of the human erythroid Rh glycoprotein (RhAG) enhances both NH3 and NH4+ transport in HeLa cells

Pflugers Archiv European Journal of Physiology

Volumn 450, Issue 3, 2005, Pages 155-167

  Benjelloun, Fatine ^a   Bakouh, Naziha ^a   Fritsch, Janine ^b   Hulin, Philippe ^a   Lipecka, Joanna ^a   Edelman, Aleksander ^a   Planelles, Gabrielle ^a   Thomas, S Randall ^a   Chérif Zahar, Baya ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b CNRS   (France)

Author keywords

Ammonium; Intracellular pH; Rh proteins

Indexed keywords

AMMONIA; AMMONIUM CHLORIDE; FLUORESCENT DYE; GLYCOPROTEIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; ISOPROTEIN; METHYLAMMONIUM; RH GLYCOPROTEIN; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ACIDIFICATION; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL PH; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPOSURE; FEMALE; HELA CELL; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

AMMONIA; BARIUM COMPOUNDS; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; CHLORIDES; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; OUABAIN; QUATERNARY AMMONIUM COMPOUNDS; RECOMBINANT FUSION PROTEINS; SODIUM-HYDROGEN ANTIPORTER;

EID: 21244456328     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-005-1381-y     Document Type: Article

References (48)

1. Avent ND, Reid ME (2000) The Rh blood group system: a review. Blood 95:375-387
2. + transport induced by the functional expression of the human Rh C glycoprotein. J Biol Chem 279:15975-15983
3. + of thick ascending limbs of rat kidney: evidence from isolated membranes. J Physiol (Lond) 506:689-698
4. Bockriss JOM, Reddy AKN (1970) Modern electrochemistry. Plenum Press, New York
5. + and of ionic weak acids and bases. J Membr Biol 72:1-16
6. 3, and metabolic inhibitors. J Gen Physiol 67:91-112
7. Bouyer P, Cougnon M, Thomas SR, Hulin P, Anagnostopoulos T, Planelles G (1997) Symmetric pH dependence of buffering power in giant fused cells from frog kidney proximal tubule. Am J Physiol 272:R1226-R1234
8. 3. Am J Physiol 255:C844-C856
9. Bruce LJ, Beckmann R, Ribeiro ML, Peters LL, Chasis JA, Delaunay J, Mohandas N, Anstee DJ, Tanner MJ (2003) A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane. Blood 101:4180-4188
10. Cartron JP (1999) RH blood group system and molecular basis of Rh-deficiency. Baillieres Best Pract Res Clin Haematol 12:655-689
11. - co-transport, intracellular buffering and intracellular pH in guinea-pig ventricular myocytes. J Physiol (Lond) 552:715-726
12. Chaudhry FA, Krizaj D, Larsson P, Reimer RJ, Wreden C, Storm-Mathisen J, Copenhagen D, Kavanaugh M, Edwards RH (2001) Coupled and uncoupled proton movement by amino acid transport system N. EMBO J 20:7041-7051
13. Cherif-Zahar B, Raynal V, Gane P, Mattei MG, Bailly P, Gibbs B, Colin Y, Cartron JP (1996) Candidate gene acting as a suppressor of the RH locus in most cases of Rh-deficiency. Nat Genet 12:168-173
14. Conn HO (1966) Studies on the origin and significance of blood ammonia. II. The distribution of ammonia in whole blood, plasma and erythrocytes of man. Yale J Biol Med 39:38-53
15. Eyers SA, Ridgwell K, Mawby WJ, Tanner MJ (1994) Topology and organization of human Rh (rhesus) blood group-related polypeptides. J Biol Chem 269:6417-6423
16. Goldman DE (1943) Potential, impedance, and rectification in membranes. J Gen Physiol 27:37-60
17. Hemker MB, Cheroutre G, van Zwieten R, Maaskant-van Wijk PA, Roos D, Loos JA, van der School CE, von dem Borne AE (2003) The Rh complex exports ammonium from human red blood cells. Br J Haematol 122:333-340
18. Hodgkin AL Katz B (1949) The effect of sodium ions on the electrical activity of the giant axon of the squid. J Physiol (Lond) 108:37-77
19. Huang CH, Cheng G, Liu Z, Chen Y, Reid ME, Halverson G, Okubo Y (1999) Molecular basis for Rh(null) syndrome: identification of three new missense mutations in the Rh50 glycoprotein gene. Am J Hematol 62:25-32
20. Huang CH, Liu PZ (2001) New insights into the Rh superfamily of genes and proteins in erythroid cells and nonerythroid tissues. Blood Cells Mol Dis 27:90-101
21. Javelle A, Severi E, Thornton J, Merrick M (2004) Ammonium sensing in E. coli: the role of the ammonium transporter AmtB and AmtB-GlnK complex formation. J Biol Chem 279:8530-8538
22. Khademi S, O'Connell J III, Remis J, Robles-Colmenares Y, Miercke LJ, Stroud RM (2004) Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 Å. Science 305:1587-1594
23. Kitano T, Saitou N (2000) Evolutionary history of the Rh blood group-related genes in vertebrates. Immunogenetics 51:856-862
24. Klocke RA, Andersson KK, Rotman HH, Forster RE (1972) Permeability of human erythrocytes to ammonia and weak acids. Am J Physiol 222:1004-1013
25. --cotransport system in HeLa cells and HeLa cell mutants exhibiting an altered efflux pathway. J Cell Physiol 141:181-190
26. - cotransport system in HeLa cells: aspects of its physiological regulation. J Cell Physiol 145:253-261
27. 3 fluxes across apical membrane of macula densa cells: a quantitative analysis. Am J Physiol 273:F817-F824
28. Labotka RJ, Lundberg P, Kuchel PW (1995) Ammonia permeability of erythrocyte membrane studied by 14N and 15N saturation transfer NMR spectroscopy. Am J Physiol 268:C686-C699
29. Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH (2000) Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. J Biol Chem 275:2564-125651
30. Liu Z, Peng J, Mo R, Hui C, Huang CH (2001) Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals. J Biol Chem 276:1424-1433
31. Lorenz MC, Heitman J (1998) The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. EMBO J 17:1236-1247
32. Lucien N, Sidoux-Walter F, Roudier N, Ripoche P, Huet M, Trinh-Trang-Tan MM, Cartron JP, Bailly P (2002) Antigenic and functional properties of the human red blood cell urea transporter hUT-B1. J Biol Chem 277:34101-34108
33. 4 uniporters. J Biol Chem 278:45603-45610
34. + in glial cells of bee retina. J Gen Physiol 116:125-142
35. Marini AM, Matassi G, Raynal V, Andre B, Cartron JP, Cherif-Zahar B (2000) The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. Nat Genet 26:341-344
36. Marini AM, Springael JY, Frommer WB, Andre B (2000) Cross-talk between ammonium transporters in yeast and interference by the soybean SAT1 protein. Mol Microbiol 35:378-385
37. + transporters. Trends Biochem Sci 22:460-461
38. Matassi G, Cherif-Zahar B, Raynal V, Rouger P, Cartron JP (1998) Organization of the human RH50A gene (RHAG) and evolution of base composition of the RH gene family. Genomics 47:286-293
39. Mouro-Chanteloup I, D'Ambrosio AM, Gane P, Le Van Kim C, Raynal V, Dhermy D, Cartron JP, Colin Y (2002) Cell-surface expression of RhD blood group polypeptide is post-transcriptionally regulated by the RhAG glycoprotein. Blood 100:1038-1047
40. Nicolas V, Le Van Kim C, Gane P, Birkenmeier C, Cartron JP, Colin Y, Mouro-Chanteloup I (2003) Rh-RhAG/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation. J Biol Chem 278: 25526-25533
41. Paglia DE, Valentine WN (1981) Haemolytic anaemia associated with disorders of the purine and pyrimidine salvage pathways. Clin Haematol 10:81-98
42. Ridgwell K, Spurr NK, Laguda B, MacGeoch C, Avent ND, Tanner MJ (1992) Isolation of cDNA clones for a 50 kDa glycoprotein of the human erythrocyte membrane associated with Rh (rhesus) blood-group antigen expression. Biochem J 287:223-228
43. Robinson RR, Owen EE (1965) Intrarenal distribution of ammonia during diuresis and antidiuresis. Am J Physiol 208:1129-1134
44. Sturgeon P (1970) Hematological observations on the anemia associated with blood type Rh null. Blood 36:310-320
45. Thomas JA, Buchsbaum RN, Zimniak A, Racker E (1979) Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry 18:2210-2218
46. +-ATPaSe is critical to net acid secretion during chronic hypokalemia. Am J Physiol 277:F866-F874
47. Westhoff CM, Ferreri-Jacobia M, Mak DO, Foskett JK (2002) Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter. J Biol Chem 277:12499-12502
48. Wilding TJ, Cheng B, Roos A (1992) pH regulation in adult rat carotid body glomus cells: importance of extracellular pH, sodium, and potassium. J Gen Physiol 100:593-608