Isolation and structure elucidation of degradation products in the potential anticancer drug PAC-1

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 4, 2010, Pages 965-968

  Song, Zhen ^a   Chen, Xiaohui ^a   Zhang, Di ^a   Gong, Ping ^a   Bi, Kaishun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Characterization; Degradation product; Isolation; PAC 1; Semi preparative HPLC

Indexed keywords

(4 BENZYLPIPERAZIN 1 YL)ACETIC ACID (3 ALLYL 2 HYDROXYBENZYLIDENE)HYDRAZINE; 2 ALLYL 6 [[[2 HYDROXY 3 (2 HYDROXYPROPYL)BENZYLIDENE]HYDRAZONO]METHYL]PHENOL; 2 HYDROXY 3 (2 HYDROXYPROPYL)BENZALDEHYDE; 2 HYDROXY 3 (2 PROPENYL) [[2 HYDROXY 3 (2 PROPENYL)PHENYL]METHYLENE]HYDRAZONE; 6,6' HYDRAZINE 1,2 DIYLIDENEBIS(METHAN 1 YL 1 YLIDENE)BIS[2 (2 HYDROXYPROPYL)PHENOL]; ANTINEOPLASTIC AGENT; PAC 1; UNCLASSIFIED DRUG;

ARTICLE; DRUG DEGRADATION; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HYDRAZONES; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PIPERAZINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE; TIME FACTORS;

EID: 72149124785     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.10.007     Document Type: Article

References (7)

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