Development of a high performance liquid chromatography method for quantification of PAC-1 in rat plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 2, 2009, Pages 447-450

  Fang, Li Na ^a   Chen, Xiao Hui ^a   Song, Zhen ^a   Wang, Gang ^a   Zhao, Xu ^a   Ren, Lei ^a   Gong, Ping ^a   Bi, Kai Shun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anticancer agent; HPLC; PAC 1; Pharmacokinetics; Plasma

Indexed keywords

1 PIPERAZINEACETIC ACID; ACETIC ACID ETHYL ESTER; ACETONITRILE; ANTINEOPLASTIC AGENT; INDAPAMIDE; METHANOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTICARCINOGENIC AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BUFFERS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; DRUG STORAGE; FASTING; FREEZING; HALF-LIFE; HYDRAZONES; HYDROGEN-ION CONCENTRATION; MALE; MOLECULAR STRUCTURE; PARTICLE SIZE; PHOSPHATES; PIPERAZINES; RANDOM ALLOCATION; RATS; RATS, WISTAR; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 59049097382     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.11.024     Document Type: Article

References (14)

1. Putt K.S., Chen G.W., Pearson J.M., Sandhorst J.S., Hoagland M.S., Kwon J.T., Hwang S.K., Jin H., Churchwell M.I., Cho M.H., Doerge D.R., Helferich W.G., and Hergenrother P.J. Nat. Chem. Biol. 2 (2006) 543-550
2. P.J. Hergenrother, K.S. Put, G.W. Chen, WO 2006/128173 A2.
3. Roy S., Bayly C.I., Gareau Y., Houtzager V.M., Kargman S., Keen S.L., Rowland K., Seiden I.M., Thornberry N.A., and Nicholson D.W. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 6132-6137
4. Nakagawara A., Nakamura Y., Ikeda H., Hiwasa T., Kuida K., Su M.S., Zhao H., Cnaan A., and Sakiyama S. Cancer Res. 57 (1997) 4578-4584
5. Izban K.F., Wrone-Smith T., Hsi E.D., Schnitzer B., Quevedo M.E., and Alkan S. Am. J. Pathol. 154 (1999) 1439-1447
6. Persad R., Liu C., Wu T.T., Houlihan P.S., Hamilton S.R., Diehl A.M., and Rashid A. Modern Pathol. 17 (2004) 861-867
7. Svingen P.A., Loegering D., Rodriquez J., Meng X.W., Mesner P.W., Holbeck S., Monks A., Krajewski S., Scudiero D.A., Sausville E.A., Reed J.C., Lazebnik Y.A., and Kaufmann S.H. Clin. Cancer Res. 10 (2004) 6807-6820
8. Bidlingmeyer B.A. Practical HPLC Methodology and Applications (1992), Wiley-Interscience
9. Larson J.R., Tingstad J.E., and Swadesh J.K. HPLC-Practical and Industrial Applications: Practical and Industrial Applications (1997), CRC Press
10. Jung W.B., Mi J.K., Jang C.G., and Lee S.Y. J. Chromatogr. B 859 (2007) 69-73
11. Chen Q.H., Hou S.X., Zheng J., Bi Y.Q., Li Y.B., Yang X.J., Cai Z., and Song X.R. J. Chromatogr. B 858 (2007) 199-204
12. Liu X., Huang Y.W., Li J., Li X.B., Bi K.S., and Chen X.H. J. Pharm. Biomed. Anal. 43 (2007) 371-375
13. Guidance for industry, Bioanalytical method validation (updated 2001), http://www.fda.gov/cder/guidance/index.htm.
14. Zhao L.B., Wang X.M., Wu J.H., Jia Y.S., Wang W.Q., Zhang S.H., and Wang J.L. J. Chromatogr. B 857 (2007) 341-346